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Dr. Duke's Phytochemical and Ethnobotanical Databases
U.S. Department of Agriculture
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COX-1-Inhibitor

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List of activity chemicals.
Click on column headings to sort table by that column. *Unless otherwise noted all references are to (Duke, 1992)
Chemical Name Dosage Reference
(+)-CATECHIN IC50=183-279 uM (cf indomethacin IC50=1 uM) *
(-)-EPIAFZELECHIN IC50=15 uM/ Min, K. R. et al. 1999. (-)-epiafzelechin: Cyclooxygenase-1 Inhibitor and Anti-Inflammatory Agent from Aerial Parts of Celastrus orbiculatus. Planta Med., 65(5): 460-462.
3,4-METHYLENE-DIOXYCINNAMIC-ACID-BORNYL-ESTER IC16=100 ug/ml *
AIPHANOL *
ANTHOCYANINS IC45=125 ug/ml *
APIGENIN IC65=1,000 uM *
BAICALEIN 100 ug/ml Fukutake, M., Yokota, S., Kawamura, H., Iizuka, A., Amagaya, S., Fukuda, K., Komatsu, Y. 1998. Inhibitory effect of Coptidis rhizoma adn Scutellariae radix on azoxymethane-induced aberrant crypt foci formation in rat colon. Biol Pharm Bull, 21(8): 814-817
BETA-CAROTENE IC78=50 ug/ml *
CATECHIN IC50=80 uM (cf indomethacin IC50=1 uM) *
CINNAMIC-ACID-BORNYL-ESTER IC66=100 ug/ml *
CIRSILINEOL IC37=1,000 uM *
CIRSIMARITIN IC50=1,000 uM *
CYANIDIN-3-O-GLUCOSIDE IC30=100 ug/ml *
DIRCA-PHENOLIC-GLUCOSIDE-5 125 ug/ml Ramsewak, R. S., Nair, M. G., De Witt, D. L., Mattson, W. G., Zasada, J. 1999. Phenolic Glycosides from Dirca palustris. J. Nat. Prod., 62(11): 1558-1561.
EUGENOL IC97=1,000 uM *
FLAVOKAWAIN-B IC77=100 ug/ml *
FLAVOKAWAIN-B IC55=12.5 ug/ml *
ISOTHYMONIN IC37=1,000 uM *
LAURIC-ACID IC40=100 *
MYRICETIN-3-O-BETA-D-GLUCURONIDE IC50=0.5 uM/ Hiermann, A., Schramm, H. W., Laufer, S. 1998. Anti-Inflammatory Activity of Myricetin-3--O-beta-d-glucuronide and Related Compounds. Inflamm. Res., 47(11): 421-427.
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List of Activity Plants.
Click on column headings to sort table by that column.
Plant Name Common Name Chemical Count Total Parts Per Million
Cyamopsis tetragonoloba Guar; Cluster-Bean; Siam-Bean 1 39
Cycas revoluta Sago Cycas 1 0
Cyclanthera pedata Achocha 1 82
Cydonia oblonga Quince 1 16
Cymbopogon winterianus Java Citronella; Mahapengiri 1 466
Cynara cardunculus Artichoke 4 155
Cyphomandra betacea Tamarillo; Tree Tomato 2 64
Cyrtosperma chamissonis Swamp Taro 1 0.20000000298023224
Daphne genkwa Yuan Hua 1 0
Daucus carota Carrot 4 14, 118
Dianthus caryophyllus Carnation; Clove Pink; Oeillet (Fr.); Nelke (Ger.); Clavel (Sp.) 2 4, 350
Digitalis purpurea Purple Foxglove 1 0
Dioscorea alata Greater Yam; Winged Yam 1 0.4000000059604645
Dioscorea pentaphylla Mountain Yam 1 0
Dioscorea sp. Wild Yam 1 19
Dioscorea villosa Wild Yam 1 29
Diospyros digyna Black Sapote; Sapote Negro 1 12
Drimys winteri Winter's Bark 1 0
Durio zibethinus Durian 1 1
Echinacea angustifolia Echinacea; Narrow Leaf Echinacea; Narrow Leaf Purple-Coneflower 1 0