An official website of the United States government.

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

Dr. Duke's Phytochemical and Ethnobotanical Databases
U.S. Department of Agriculture
  1. Home
  2. COX-1-Inhibitor

COX-1-Inhibitor

Select a Results View:

Download these results as:
CSV
EXCEL
PDF
List of activity chemicals.
Click on column headings to sort table by that column. *Unless otherwise noted all references are to (Duke, 1992)
Chemical Name Dosage Reference
(+)-CATECHIN IC50=183-279 uM (cf indomethacin IC50=1 uM) *
(-)-EPIAFZELECHIN IC50=15 uM/ Min, K. R. et al. 1999. (-)-epiafzelechin: Cyclooxygenase-1 Inhibitor and Anti-Inflammatory Agent from Aerial Parts of Celastrus orbiculatus. Planta Med., 65(5): 460-462.
3,4-METHYLENE-DIOXYCINNAMIC-ACID-BORNYL-ESTER IC16=100 ug/ml *
AIPHANOL *
ANTHOCYANINS IC45=125 ug/ml *
APIGENIN IC65=1,000 uM *
BAICALEIN 100 ug/ml Fukutake, M., Yokota, S., Kawamura, H., Iizuka, A., Amagaya, S., Fukuda, K., Komatsu, Y. 1998. Inhibitory effect of Coptidis rhizoma adn Scutellariae radix on azoxymethane-induced aberrant crypt foci formation in rat colon. Biol Pharm Bull, 21(8): 814-817
BETA-CAROTENE IC78=50 ug/ml *
CATECHIN IC50=80 uM (cf indomethacin IC50=1 uM) *
CINNAMIC-ACID-BORNYL-ESTER IC66=100 ug/ml *
CIRSILINEOL IC37=1,000 uM *
CIRSIMARITIN IC50=1,000 uM *
CYANIDIN-3-O-GLUCOSIDE IC30=100 ug/ml *
DIRCA-PHENOLIC-GLUCOSIDE-5 125 ug/ml Ramsewak, R. S., Nair, M. G., De Witt, D. L., Mattson, W. G., Zasada, J. 1999. Phenolic Glycosides from Dirca palustris. J. Nat. Prod., 62(11): 1558-1561.
EUGENOL IC97=1,000 uM *
FLAVOKAWAIN-B IC77=100 ug/ml *
FLAVOKAWAIN-B IC55=12.5 ug/ml *
ISOTHYMONIN IC37=1,000 uM *
LAURIC-ACID IC40=100 *
MYRICETIN-3-O-BETA-D-GLUCURONIDE IC50=0.5 uM/ Hiermann, A., Schramm, H. W., Laufer, S. 1998. Anti-Inflammatory Activity of Myricetin-3--O-beta-d-glucuronide and Related Compounds. Inflamm. Res., 47(11): 421-427.
Download these results as:
CSV
EXCEL
PDF
List of Activity Plants.
Click on column headings to sort table by that column.
Plant Name Common Name Chemical Count Total Parts Per Million
Colocasia esculenta Taro 1 298.80000001192093
Commiphora myrrha Myrrh; African Myrrh; Herabol Myrrh; Somali Myrrh; Myrrhe (Fr., Ger.); Mirra (Sp. It.) 1 13, 800
Conyza canadensis Butterweed; Hogweed; Horseweed 1 0
Corchorus olitorius Jew's Mallow; Mulukiya; Nalta Jute 1 1, 485
Coriandrum sativum Coriander; Chinese Parsley; Cilantro 2 684
Corylus avellana English Filbert; European Filbert; European Hazel; Hazel; Cobnut 1 2.0000000298023224
Crataegus laevigata Hawthorn; English Hawthorn; Whitethorn; Woodland Hawthorn 5 20
Crataegus monogyna Hawthorn; English Hawthorn 2 0
Crataegus rhipidophylla Hawthorn 4 5.400000095367432
Crescentia alata Jicaro 1 0.20000000298023224
Crocus sativus Saffron 2 0
Croton eluteria Cascarilla 1 0
Croton lechleri Sangre de Drago; Sangre de Grado; Sangre de Dragon; Dragons Blood 2 0
Croton tiglium Purging Croton 1 250
Cucumis melo Cantaloupe; Melon; Muskmelon; Netted Melon; Persian Melon; Nutmeg Melon 2 54, 726
Cucumis sativus Cucumber 1 8
Cucurbita pepo Pumpkin 2 1, 152.5
Cucurbita spp Summer Squash 2 161.89999997615814
Cuminum cyminum Cumin 2 16
Curcuma longa Turmeric; Indian Saffron 2 8, 436