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Dr. Duke's Phytochemical and Ethnobotanical Databases
U.S. Department of Agriculture
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COX-1-Inhibitor

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List of activity chemicals.
Click on column headings to sort table by that column. *Unless otherwise noted all references are to (Duke, 1992)
Chemical Name Dosage Reference
(+)-CATECHIN IC50=183-279 uM (cf indomethacin IC50=1 uM) *
(-)-EPIAFZELECHIN IC50=15 uM/ Min, K. R. et al. 1999. (-)-epiafzelechin: Cyclooxygenase-1 Inhibitor and Anti-Inflammatory Agent from Aerial Parts of Celastrus orbiculatus. Planta Med., 65(5): 460-462.
3,4-METHYLENE-DIOXYCINNAMIC-ACID-BORNYL-ESTER IC16=100 ug/ml *
AIPHANOL *
ANTHOCYANINS IC45=125 ug/ml *
APIGENIN IC65=1,000 uM *
BAICALEIN 100 ug/ml Fukutake, M., Yokota, S., Kawamura, H., Iizuka, A., Amagaya, S., Fukuda, K., Komatsu, Y. 1998. Inhibitory effect of Coptidis rhizoma adn Scutellariae radix on azoxymethane-induced aberrant crypt foci formation in rat colon. Biol Pharm Bull, 21(8): 814-817
BETA-CAROTENE IC78=50 ug/ml *
CATECHIN IC50=80 uM (cf indomethacin IC50=1 uM) *
CINNAMIC-ACID-BORNYL-ESTER IC66=100 ug/ml *
CIRSILINEOL IC37=1,000 uM *
CIRSIMARITIN IC50=1,000 uM *
CYANIDIN-3-O-GLUCOSIDE IC30=100 ug/ml *
DIRCA-PHENOLIC-GLUCOSIDE-5 125 ug/ml Ramsewak, R. S., Nair, M. G., De Witt, D. L., Mattson, W. G., Zasada, J. 1999. Phenolic Glycosides from Dirca palustris. J. Nat. Prod., 62(11): 1558-1561.
EUGENOL IC97=1,000 uM *
FLAVOKAWAIN-B IC77=100 ug/ml *
FLAVOKAWAIN-B IC55=12.5 ug/ml *
ISOTHYMONIN IC37=1,000 uM *
LAURIC-ACID IC40=100 *
MYRICETIN-3-O-BETA-D-GLUCURONIDE IC50=10 uM/ Hiermann, A., Schramm, H. W., Laufer, S. 1998. Anti-Inflammatory Activity of Myricetin-3--O-beta-d-glucuronide and Related Compounds. Inflamm. Res., 47(11): 421-427.
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List of Activity Plants.
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Plant Name Common Name Chemical Count Total Parts Per Million
Byrsonima crassifolia Nance 1 2.799999952316284
Cajanus cajan Pigeonpea 1 8.599999904632568
Calamintha nepeta Turkish Calamint 1 8
Calathea macrosepala Chufle 1 0
Calendula officinalis Calendula; Pot-Marigold 1 35, 000
Camellia sinensis Tea 6 13, 290
Cananga odorata Cananga; Ylang-Ylang 1 0
Canavalia ensiformis Jack Bean 1 2.400000050663948
Canna indica Achira; Queensland Arrowroot 1 0.6000000238418579
Cannabis sativa Marijuana; Marihuana; Indian Hemp; Hemp 1 0.23999999463558197
Capparis spinosa Caper; Caperbush 1 0
Capsella bursa-pastoris Shepherd's Purse 1 22
Capsicum annuum Bell Pepper; Green Pepper; Cherry Pepper; Sweet Pepper; Cone Pepper; Paprika 2 570
Capsicum frutescens Cayenne; Chili; Tabasco; Hot Pepper; Spur Pepper; Red Chili 2 228
Carica papaya Papaya 2 4, 604
Carica pentagona Babaco; Mountain papaya 1 18
Carthamus tinctorius Safflower 2 90
Carum carvi Caraway; Carum; Kummel (Ger.); Comino (Sp.); Comino de prado (Sp.) 2 1, 120
Carya illinoensis Pecan 3 0.8299999833106995
Casimiroa edulis Matasano; White sapote 1 4.800000190734863