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Dr. Duke's Phytochemical and Ethnobotanical Databases
U.S. Department of Agriculture
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COX-1-Inhibitor

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List of activity chemicals.
Click on column headings to sort table by that column. *Unless otherwise noted all references are to (Duke, 1992)
Chemical Name Dosage Reference
(+)-CATECHIN IC50=183-279 uM (cf indomethacin IC50=1 uM) *
(-)-EPIAFZELECHIN IC50=15 uM/ Min, K. R. et al. 1999. (-)-epiafzelechin: Cyclooxygenase-1 Inhibitor and Anti-Inflammatory Agent from Aerial Parts of Celastrus orbiculatus. Planta Med., 65(5): 460-462.
3,4-METHYLENE-DIOXYCINNAMIC-ACID-BORNYL-ESTER IC16=100 ug/ml *
AIPHANOL *
ANTHOCYANINS IC45=125 ug/ml *
APIGENIN IC65=1,000 uM *
BAICALEIN 100 ug/ml Fukutake, M., Yokota, S., Kawamura, H., Iizuka, A., Amagaya, S., Fukuda, K., Komatsu, Y. 1998. Inhibitory effect of Coptidis rhizoma adn Scutellariae radix on azoxymethane-induced aberrant crypt foci formation in rat colon. Biol Pharm Bull, 21(8): 814-817
BETA-CAROTENE IC78=50 ug/ml *
CATECHIN IC50=80 uM (cf indomethacin IC50=1 uM) *
CINNAMIC-ACID-BORNYL-ESTER IC66=100 ug/ml *
CIRSILINEOL IC37=1,000 uM *
CIRSIMARITIN IC50=1,000 uM *
CYANIDIN-3-O-GLUCOSIDE IC30=100 ug/ml *
DIRCA-PHENOLIC-GLUCOSIDE-5 125 ug/ml Ramsewak, R. S., Nair, M. G., De Witt, D. L., Mattson, W. G., Zasada, J. 1999. Phenolic Glycosides from Dirca palustris. J. Nat. Prod., 62(11): 1558-1561.
EUGENOL IC97=1,000 uM *
FLAVOKAWAIN-B IC77=100 ug/ml *
FLAVOKAWAIN-B IC55=12.5 ug/ml *
ISOTHYMONIN IC37=1,000 uM *
LAURIC-ACID IC40=100 *
MYRICETIN-3-O-BETA-D-GLUCURONIDE IC50=0.5 uM/ Hiermann, A., Schramm, H. W., Laufer, S. 1998. Anti-Inflammatory Activity of Myricetin-3--O-beta-d-glucuronide and Related Compounds. Inflamm. Res., 47(11): 421-427.
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List of Activity Plants.
Click on column headings to sort table by that column.
Plant Name Common Name Chemical Count Total Parts Per Million
Catha edulis Khat 1 18
Caulophyllum thalictroides Blue Cohosh 1 24
Centaurea calcitrapa Star-Thistle 1 0
Centaurea cyanus Cornflower; Bachelor's Button 1 0
Centella asiatica Gotu Kola; Pennywort 1 738
Ceratonia siliqua Carob; St.John's-Bread; Locust Bean 1 0
Chamaemelum nobile Garden Camomile; Perennial Camomile; Roman Camomile 2 6.6000001430511475
Chenopodium album Lambsquarter 1 316
Chenopodium ambrosioides Epazote; Wormseed 1 330
Chondrus crispus Irish Moss 1 55
Chrysanthemum coronarium Garland Chrysanthemum 1 1, 668
Chrysanthemum parthenium Feverfew 1 28
Chrysobalanus icaco Cocoa plum; Icaco 1 10
Chrysophyllum cainito Caimito; Star Apple 1 1.7999999523162842
Cicer arietinum Chickpea; Garbanzo 1 1
Cichorium endivia Endive; Escarole 1 482
Cichorium intybus Chicory; Witloof; Succory 2 684
Cimicifuga racemosa Black Cohosh; Black Snakeroot 1 48
Cinnamomum aromaticum Cassia; Cassia Bark; Cassia Lignea; Chinese Cassia; Chinese Cinnamon; China Junk Cassia; Saigon Cinnamon; Zimtcassie (Ger.); Canela de la China (Sp.); Canelero chino (Sp.); Chinazimt (Ger.); Chinesischer Zimtbaum (Ger.); Kashia-Keihi (Jap.); Canelle de Cochinchine (Fr.); Cannelier Casse (Fr.); Cannelier de Chine (Fr.) 3 12, 432
Cinnamomum camphora Camphor; Ho Leaf 2 0