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Dr. Duke's Phytochemical and Ethnobotanical Databases
U.S. Department of Agriculture
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COX-1-Inhibitor

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List of activity chemicals.
Click on column headings to sort table by that column. *Unless otherwise noted all references are to (Duke, 1992)
Chemical Name Dosage Reference
(+)-CATECHIN IC50=183-279 uM (cf indomethacin IC50=1 uM) *
(-)-EPIAFZELECHIN IC50=15 uM/ Min, K. R. et al. 1999. (-)-epiafzelechin: Cyclooxygenase-1 Inhibitor and Anti-Inflammatory Agent from Aerial Parts of Celastrus orbiculatus. Planta Med., 65(5): 460-462.
3,4-METHYLENE-DIOXYCINNAMIC-ACID-BORNYL-ESTER IC16=100 ug/ml *
AIPHANOL *
ANTHOCYANINS IC45=125 ug/ml *
APIGENIN IC65=1,000 uM *
BAICALEIN 100 ug/ml Fukutake, M., Yokota, S., Kawamura, H., Iizuka, A., Amagaya, S., Fukuda, K., Komatsu, Y. 1998. Inhibitory effect of Coptidis rhizoma adn Scutellariae radix on azoxymethane-induced aberrant crypt foci formation in rat colon. Biol Pharm Bull, 21(8): 814-817
BETA-CAROTENE IC78=50 ug/ml *
CATECHIN IC50=80 uM (cf indomethacin IC50=1 uM) *
CINNAMIC-ACID-BORNYL-ESTER IC66=100 ug/ml *
CIRSILINEOL IC37=1,000 uM *
CIRSIMARITIN IC50=1,000 uM *
CYANIDIN-3-O-GLUCOSIDE IC30=100 ug/ml *
DIRCA-PHENOLIC-GLUCOSIDE-5 125 ug/ml Ramsewak, R. S., Nair, M. G., De Witt, D. L., Mattson, W. G., Zasada, J. 1999. Phenolic Glycosides from Dirca palustris. J. Nat. Prod., 62(11): 1558-1561.
EUGENOL IC97=1,000 uM *
FLAVOKAWAIN-B IC77=100 ug/ml *
FLAVOKAWAIN-B IC55=12.5 ug/ml *
ISOTHYMONIN IC37=1,000 uM *
LAURIC-ACID IC40=100 *
MYRICETIN-3-O-BETA-D-GLUCURONIDE IC50=0.5 uM/ Hiermann, A., Schramm, H. W., Laufer, S. 1998. Anti-Inflammatory Activity of Myricetin-3--O-beta-d-glucuronide and Related Compounds. Inflamm. Res., 47(11): 421-427.
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List of Activity Plants.
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Plant Name Common Name Chemical Count Total Parts Per Million
Cinnamomum sieboldii Japanese Cinnamon 1 0
Cinnamomum verum Cinnamon; Ceylon Cinnamon 3 3, 405, 204
Cistus ladaniferus Ambreine; Gum Cistus; Labdanum; Rockrose 1 4, 200
Citrullus colocynthis Colocynth 1 0
Citrullus lanatus Watermelon 2 3, 298
Citrus aurantiifolia Lime 1 2
Citrus aurantium Petitgrain; Bitter Orange 1 54
Citrus limon Lemon 1 2
Citrus paradisi Grapefruit 1 5
Citrus reticulata Mandarin; Tangerine 3 90.79999995231628
Citrus sinensis Orange 1 28
Cnicus benedictus Blessed Thistle 2 133
Cnidoscolus chayamansa Chaya 1 425
Coccinia grandis Ivy Gourd; Kundree; Tindora; Tindori; Pepasan; Little Gourd; Kanduri 1 1, 582
Cocos nucifera Coconut; Coconut Palm; Copra; Nariyal; Kokospalme (Ger.); Cocotero (Sp.) 1 2, 588, 400
Coffea arabica Coffee 2 25
Coix lacryma-jobi Adlay; Adlay Millet; Job'S-Tears; Yi-Yi-Ren 1 0
Cola acuminata Abata Cola 1 1
Colchicum autumnale Autumn Crocus; Meadow Saffron 1 0
Collinsonia canadensis Stone Root 1 0