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Dr. Duke's Phytochemical and Ethnobotanical Databases
U.S. Department of Agriculture
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COX-1-Inhibitor

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List of activity chemicals.
Click on column headings to sort table by that column. *Unless otherwise noted all references are to (Duke, 1992)
Chemical Name Dosage Reference
(+)-CATECHIN IC50=183-279 uM (cf indomethacin IC50=1 uM) *
(-)-EPIAFZELECHIN IC50=15 uM/ Min, K. R. et al. 1999. (-)-epiafzelechin: Cyclooxygenase-1 Inhibitor and Anti-Inflammatory Agent from Aerial Parts of Celastrus orbiculatus. Planta Med., 65(5): 460-462.
3,4-METHYLENE-DIOXYCINNAMIC-ACID-BORNYL-ESTER IC16=100 ug/ml *
AIPHANOL *
ANTHOCYANINS IC45=125 ug/ml *
APIGENIN IC65=1,000 uM *
BAICALEIN 100 ug/ml Fukutake, M., Yokota, S., Kawamura, H., Iizuka, A., Amagaya, S., Fukuda, K., Komatsu, Y. 1998. Inhibitory effect of Coptidis rhizoma adn Scutellariae radix on azoxymethane-induced aberrant crypt foci formation in rat colon. Biol Pharm Bull, 21(8): 814-817
BETA-CAROTENE IC78=50 ug/ml *
CATECHIN IC50=80 uM (cf indomethacin IC50=1 uM) *
CINNAMIC-ACID-BORNYL-ESTER IC66=100 ug/ml *
CIRSILINEOL IC37=1,000 uM *
CIRSIMARITIN IC50=1,000 uM *
CYANIDIN-3-O-GLUCOSIDE IC30=100 ug/ml *
DIRCA-PHENOLIC-GLUCOSIDE-5 125 ug/ml Ramsewak, R. S., Nair, M. G., De Witt, D. L., Mattson, W. G., Zasada, J. 1999. Phenolic Glycosides from Dirca palustris. J. Nat. Prod., 62(11): 1558-1561.
EUGENOL IC97=1,000 uM *
FLAVOKAWAIN-B IC77=100 ug/ml *
FLAVOKAWAIN-B IC55=12.5 ug/ml *
ISOTHYMONIN IC37=1,000 uM *
LAURIC-ACID IC40=100 *
MYRICETIN-3-O-BETA-D-GLUCURONIDE IC50=0.5 uM/ Hiermann, A., Schramm, H. W., Laufer, S. 1998. Anti-Inflammatory Activity of Myricetin-3--O-beta-d-glucuronide and Related Compounds. Inflamm. Res., 47(11): 421-427.
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List of Activity Plants.
Click on column headings to sort table by that column.
Plant Name Common Name Chemical Count Total Parts Per Million
Oryza sativa Rice 1 0
Oxalis tuberosa Oca; Papa Roja; Quiba 1 0.6000000089406967
Pachira macrocarpa Large-Fruited Provision Tree 1 13
Pachyrhizus erosus Yambean 1 0
Panax ginseng Chinese Ginseng; Oriental Ginseng; Ginseng; Korean Ginseng 2 0
Papaver somniferum Opium Poppy; Poppyseed Poppy 2 0
Parthenium integrifolium Feverfew; American Feverfew; Wild Quinine; Missouri Snakeroot; Prairie-Dock 1 210
Passiflora edulis Maracuya; Passionfruit 1 34
Passiflora foetida Granadilla Cimarrona; Stinking Granadilla 1 0
Passiflora incarnata Manzana de Mayo; Mayapple; Passionflower 2 144
Passiflora ligularis Granadilla; Sweet Granadilla 1 2.4000000953674316
Passiflora mollissima Banana Passionfruit; Granadilla De Guineo 1 2.4000000953674316
Passiflora quadrangularis Granadilla 1 1
Pastinaca sativa Parsnip 1 1
Pelargonium graveolens Rose Geranium; Scented Geranium 1 0
Peperomia pelucida Pepper elder; Yerba de la plata 1 640
Peperomia pereskiifolia Perejil 1 920
Pereskia aculeata Barbados Gooseberry; Grosela Americana 1 1, 112
Perideridia gairdneri Squaw Root 1 5
Perilla frutescens Perilla 4 17, 679