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Dr. Duke's Phytochemical and Ethnobotanical Databases
U.S. Department of Agriculture
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COX-1-Inhibitor

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List of activity chemicals.
Click on column headings to sort table by that column. *Unless otherwise noted all references are to (Duke, 1992)
Chemical Name Dosage Reference
(+)-CATECHIN IC50=183-279 uM (cf indomethacin IC50=1 uM) *
(-)-EPIAFZELECHIN IC50=15 uM/ Min, K. R. et al. 1999. (-)-epiafzelechin: Cyclooxygenase-1 Inhibitor and Anti-Inflammatory Agent from Aerial Parts of Celastrus orbiculatus. Planta Med., 65(5): 460-462.
3,4-METHYLENE-DIOXYCINNAMIC-ACID-BORNYL-ESTER IC16=100 ug/ml *
AIPHANOL *
ANTHOCYANINS IC45=125 ug/ml *
APIGENIN IC65=1,000 uM *
BAICALEIN 100 ug/ml Fukutake, M., Yokota, S., Kawamura, H., Iizuka, A., Amagaya, S., Fukuda, K., Komatsu, Y. 1998. Inhibitory effect of Coptidis rhizoma adn Scutellariae radix on azoxymethane-induced aberrant crypt foci formation in rat colon. Biol Pharm Bull, 21(8): 814-817
BETA-CAROTENE IC78=50 ug/ml *
CATECHIN IC50=80 uM (cf indomethacin IC50=1 uM) *
CINNAMIC-ACID-BORNYL-ESTER IC66=100 ug/ml *
CIRSILINEOL IC37=1,000 uM *
CIRSIMARITIN IC50=1,000 uM *
CYANIDIN-3-O-GLUCOSIDE IC30=100 ug/ml *
DIRCA-PHENOLIC-GLUCOSIDE-5 125 ug/ml Ramsewak, R. S., Nair, M. G., De Witt, D. L., Mattson, W. G., Zasada, J. 1999. Phenolic Glycosides from Dirca palustris. J. Nat. Prod., 62(11): 1558-1561.
EUGENOL IC97=1,000 uM *
FLAVOKAWAIN-B IC77=100 ug/ml *
FLAVOKAWAIN-B IC55=12.5 ug/ml *
ISOTHYMONIN IC37=1,000 uM *
LAURIC-ACID IC40=100 *
MYRICETIN-3-O-BETA-D-GLUCURONIDE IC50=0.5 uM/ Hiermann, A., Schramm, H. W., Laufer, S. 1998. Anti-Inflammatory Activity of Myricetin-3--O-beta-d-glucuronide and Related Compounds. Inflamm. Res., 47(11): 421-427.
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List of Activity Plants.
Click on column headings to sort table by that column.
Plant Name Common Name Chemical Count Total Parts Per Million
Lupinus mutabilis Andean Lupine; Chocho; Tarhui 1 7.5
Lycium barbarum Barbary Matrimony Vine; Ning Xia Gou Qi (Chin.); Matrimony Vine; Common Matrimony Vine; Duke of Argyll's Eta Tree 1 450
Lycium chinense Wolfberry; Chinese Boxthorn; Chinese Matrimony Vine; Chinese Wolfberry; Gou Qi (Chin.); Lyciet de Chine (Fr.); Chinesischer Bocksdorn (Ger.); Daun Koki (Indones.); Spina Santa Cinese (Ital.); Kuko (Jap.); Kaukichai (Malays.) 1 4, 708
Lycopersicon esculentum Tomato 2 113
Lycopodium clavatum Antler Herb; Clubmoss 1 0
Lycopodium selago Clubmoss 1 0
Lycopus europeus European Bugle 1 37, 000
Lycopus virginicus Bugle 1 0
Lythrum salicaria Purple Loosestrife 1 10, 000
Macadamia spp Macadamia 2 10, 850
Maclura pomifera Osage-Orange; Hedge Apple 2 10
Magnolia kobus Hsin-I; Xin-Yi 1 0
Malpighia glabra Acerola 1 69
Malus domestica Apple 4 139
Malva sylvestris High Mallow 2 70, 390
Mammea americana Mamey 1 24
Mangifera indica Mango 2 195
Manihot esculenta Cassava; Tapioca; Yuca 2 546
Manilkara zapota Sapodilla 1 1
Maranta arundinacea Arrowroot; Bermuda Arrowroot 1 0