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Dr. Duke's Phytochemical and Ethnobotanical Databases
U.S. Department of Agriculture
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COX-1-Inhibitor

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List of activity chemicals.
Click on column headings to sort table by that column. *Unless otherwise noted all references are to (Duke, 1992)
Chemical Name Dosage Reference
(+)-CATECHIN IC50=183-279 uM (cf indomethacin IC50=1 uM) *
(-)-EPIAFZELECHIN IC50=15 uM/ Min, K. R. et al. 1999. (-)-epiafzelechin: Cyclooxygenase-1 Inhibitor and Anti-Inflammatory Agent from Aerial Parts of Celastrus orbiculatus. Planta Med., 65(5): 460-462.
3,4-METHYLENE-DIOXYCINNAMIC-ACID-BORNYL-ESTER IC16=100 ug/ml *
AIPHANOL *
ANTHOCYANINS IC45=125 ug/ml *
APIGENIN IC65=1,000 uM *
BAICALEIN 100 ug/ml Fukutake, M., Yokota, S., Kawamura, H., Iizuka, A., Amagaya, S., Fukuda, K., Komatsu, Y. 1998. Inhibitory effect of Coptidis rhizoma adn Scutellariae radix on azoxymethane-induced aberrant crypt foci formation in rat colon. Biol Pharm Bull, 21(8): 814-817
BETA-CAROTENE IC78=50 ug/ml *
CATECHIN IC50=80 uM (cf indomethacin IC50=1 uM) *
CINNAMIC-ACID-BORNYL-ESTER IC66=100 ug/ml *
CIRSILINEOL IC37=1,000 uM *
CIRSIMARITIN IC50=1,000 uM *
CYANIDIN-3-O-GLUCOSIDE IC30=100 ug/ml *
DIRCA-PHENOLIC-GLUCOSIDE-5 125 ug/ml Ramsewak, R. S., Nair, M. G., De Witt, D. L., Mattson, W. G., Zasada, J. 1999. Phenolic Glycosides from Dirca palustris. J. Nat. Prod., 62(11): 1558-1561.
EUGENOL IC97=1,000 uM *
FLAVOKAWAIN-B IC77=100 ug/ml *
FLAVOKAWAIN-B IC55=12.5 ug/ml *
ISOTHYMONIN IC37=1,000 uM *
LAURIC-ACID IC40=100 *
MYRICETIN-3-O-BETA-D-GLUCURONIDE IC50=10 uM/ Hiermann, A., Schramm, H. W., Laufer, S. 1998. Anti-Inflammatory Activity of Myricetin-3--O-beta-d-glucuronide and Related Compounds. Inflamm. Res., 47(11): 421-427.
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List of Activity Plants.
Click on column headings to sort table by that column.
Plant Name Common Name Chemical Count Total Parts Per Million
Pinus strobus Eastern White Pine; White Pine 1 0
Pinus sylvestris Scotch Pine 2 0
Piper auritum Cordoncillo; Hierba Santa; Hoja Santa 2 579
Piper betel Betel Pepper 2 18, 025
Piper methysticum Kava-Kava 3 370
Piper nigrum Black Pepper; Pepper; White Pepper 5 1, 341.384000018239
Pistacia vera Pistachio 1 1.4600000381469727
Pisum sativum Pea 1 26.500000953674316
Plantago major Common Plantain 3 0
Plantago psyllium Psyllium 1 48
Platycodon grandiflorum Balloon Flower; Chieh-Keng; Jie-Geng 1 0
Plectranthus amboinicus Amboini Coleus; Country Borage; Cuban Oregano; French Thyme; Indian Borage; Soup Mint; Spanish Thyme; Mexican Mint 1 1, 400
Pogostemon cablin Patchouli 2 0
Polianthes tuberosa Tuberose 1 0
Polygonum aviculare Prostrate Knotweed 1 0
Polygonum multiflorum Chinese Cornbind; Fleeceflower; Fo Ti; He Shou Wu; Chinese Knotweed 2 37, 712.00000047684
Polymnia edulis Andean Jicama 1 10
Polypodium vulgare Common Polypody; Sweet Fern 1 0
Portulaca oleracea Purslane; Verdolaga 1 9, 300
Pourouma cecropiaefolia Tree Grape; Uvilla 1 0