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Dr. Duke's Phytochemical and Ethnobotanical Databases
U.S. Department of Agriculture
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COX-1-Inhibitor

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List of activity chemicals.
Click on column headings to sort table by that column. *Unless otherwise noted all references are to (Duke, 1992)
Chemical Name Dosage Reference
(+)-CATECHIN IC50=183-279 uM (cf indomethacin IC50=1 uM) *
(-)-EPIAFZELECHIN IC50=15 uM/ Min, K. R. et al. 1999. (-)-epiafzelechin: Cyclooxygenase-1 Inhibitor and Anti-Inflammatory Agent from Aerial Parts of Celastrus orbiculatus. Planta Med., 65(5): 460-462.
3,4-METHYLENE-DIOXYCINNAMIC-ACID-BORNYL-ESTER IC16=100 ug/ml *
AIPHANOL *
ANTHOCYANINS IC45=125 ug/ml *
APIGENIN IC65=1,000 uM *
BAICALEIN 100 ug/ml Fukutake, M., Yokota, S., Kawamura, H., Iizuka, A., Amagaya, S., Fukuda, K., Komatsu, Y. 1998. Inhibitory effect of Coptidis rhizoma adn Scutellariae radix on azoxymethane-induced aberrant crypt foci formation in rat colon. Biol Pharm Bull, 21(8): 814-817
BETA-CAROTENE IC78=50 ug/ml *
CATECHIN IC50=80 uM (cf indomethacin IC50=1 uM) *
CINNAMIC-ACID-BORNYL-ESTER IC66=100 ug/ml *
CIRSILINEOL IC37=1,000 uM *
CIRSIMARITIN IC50=1,000 uM *
CYANIDIN-3-O-GLUCOSIDE IC30=100 ug/ml *
DIRCA-PHENOLIC-GLUCOSIDE-5 125 ug/ml Ramsewak, R. S., Nair, M. G., De Witt, D. L., Mattson, W. G., Zasada, J. 1999. Phenolic Glycosides from Dirca palustris. J. Nat. Prod., 62(11): 1558-1561.
EUGENOL IC97=1,000 uM *
FLAVOKAWAIN-B IC77=100 ug/ml *
FLAVOKAWAIN-B IC55=12.5 ug/ml *
ISOTHYMONIN IC37=1,000 uM *
LAURIC-ACID IC40=100 *
MYRICETIN-3-O-BETA-D-GLUCURONIDE IC50=0.5 uM/ Hiermann, A., Schramm, H. W., Laufer, S. 1998. Anti-Inflammatory Activity of Myricetin-3--O-beta-d-glucuronide and Related Compounds. Inflamm. Res., 47(11): 421-427.
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List of Activity Plants.
Click on column headings to sort table by that column.
Plant Name Common Name Chemical Count Total Parts Per Million
Persea americana Avocado 1 27
Persea schiedeana Palta De Monte; Wild Avocado; Wild Pear 1 4.199999928474426
Petasites hybridus European Butterbur 1 0
Petasites japonicus Butterbur 1 0.5
Petroselinum crispum Parsley 3 154
Peumus boldus Boldo 1 0
Phaseolus coccineus Scarlet Runner Bean 1 0.2500000074505806
Phaseolus lunatus Butter Bean; Lima Bean 1 21.200000405311584
Phaseolus vulgaris Black Bean; Green Bean; Haricot Bean; Garden Bean; String Bean; Dwarf Bean; Field Bean; Flageolet Bean; French Bean; Kidney Bean; Navy Bean; Pop Bean; Popping Bean; Snap Bean; Wax Bean; Haricot Vert; Haricot 3 444, 912.1000032425
Phoenix dactylifera Date Palm 3 54, 003.59999990463
Phragmites australis Common Reed; Ditch Reed; Giant Reed; Reed Grass 1 200
Phyllanthus acidus Indian Gooseberry; Otaheite Gooseberry 1 16
Phyllanthus emblica Emblic; Myrobalan 1 8
Physalis ixocarpa Tomatillo 1 6
Physalis peruviana Cape Gooseberry; Ground Cherry 1 168
Phytolacca americana Pokeweed 1 621
Pimenta dioica Allspice; Jamaica-Pepper; Pimenta; Clover-Pepper; Pimento 2 6, 917, 620
Pimenta racemosa Bayrum Tree; West Indian Bay 1 43, 680
Pimpinella anisum Anise; Sweet Cumin 2 0
Pinus cembroides Mexican Pinyon 1 0.20000000298023224