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Dr. Duke's Phytochemical and Ethnobotanical Databases
U.S. Department of Agriculture
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Aldose-Reductase-Inhibitor

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List of activity chemicals.
Click on column headings to sort table by that column. *Unless otherwise noted all references are to (Duke, 1992)
Chemical Name Dosage Reference
KUWANON-C 100 uM Yamaguchi, T., Sato, J., Mihashi, H., Nomura, T. 1991. Aldose Reductase Inhibitors Containing Benzopyrans for Treatment of Diseases Associated with Diabetes. Patent, Japan Kokai Tokkyo Koho-03 68,517. 9pp.
LICORICIDIN 100 uM Yamaguchi, T., Sato, J., Mihashi, H., Nomura, T. 1991. Aldose Reductase Inhibitors Containing Benzopyrans for Treatment of Diseases Associated with Diabetes. Patent, Japan Kokai Tokkyo Koho-03 68,517. 9pp.
LICURASIDE IC50=0.56 uM *
LINARIIN IC18=10uM Shimizu, M., Ito, T., Terashima, S., Hayashi, T., Arisawa, M., Morita, N., Kurokawa, S., Ito, K., and Hashimoto, Y. 1984. Inhibition of Lens Aldose Reductase by Flavonoids. Phytochemistry, 23: 1885-1888.
LINARIN IC20=10 uM Shimizu, M., Ito, T., Terashima, S., Hayashi, T., Arisawa, M., Morita, N., Kurokawa, S., Ito, K., and Hashimoto, Y. 1984. Inhibition of Lens Aldose Reductase by Flavonoids. Phytochemistry, 23: 1885-1888.
LONICERIN IC56=1uM; IC92=10uM Shimizu, M., Ito, T., Terashima, S., Hayashi, T., Arisawa, M., Morita, N., Kurokawa, S., Ito, K., and Hashimoto, Y. 1984. Inhibition of Lens Aldose Reductase by Flavonoids. Phytochemistry, 23: 1885-1888.
LUTEOLIN EC=3 ppm Shin*, K.H., Chung, M.S., Chae, Y.J., Yoon, K.Y., Cho, T.S. 1992. A survey for aldose reductase inhibition of herbal medicines. Fitoterapia 64(2): 130, 1993.
LUTEOLIN IC50=0.45 uM rat *
LUTEOLIN-7-GLUCOSIDE IC73=10 uM *
LUTEOLIN-7-GLUCOSIDE IC31=1 uM Shimizu, M., Ito, T., Terashima, S., Hayashi, T., Arisawa, M., Morita, N., Kurokawa, S., Ito, K., and Hashimoto, Y. 1984. Inhibition of Lens Aldose Reductase by Flavonoids. Phytochemistry, 23: 1885-1888.
LUTEOLIN-7-GLUCURONIDE IC88=10 uM *
LUTEOLIN-7-GLUCURONIDE IC68=1 uM Shimizu, M., Ito, T., Terashima, S., Hayashi, T., Arisawa, M., Morita, N., Kurokawa, S., Ito, K., and Hashimoto, Y. 1984. Inhibition of Lens Aldose Reductase by Flavonoids. Phytochemistry, 23: 1885-1888.
LUTEOLIN-7-O-BETA-D-GLUCOPYRANOSIDURONIC-ACID IC50=3.1 uM rat Yoshikawa, M., et al. 1999. Medicinal Flowers. I. Aldose Reductase Inhibitors and Three New Eudesmane-Type Sesquiterpenes, Kikkanols A, B, and C, From the Flowers of Chrysanthemum inducum L. Chem Pharm Bull, 47(3): 340-345.
MACROCARPAL-A IC50=2 uM *
MACROCARPAL-A IC50=10 uM *
MACROCARPAL-B IC50=2.8 uM *
MACROCARPAL-D IC50=2 uM *
MACROCARPAL-G IC50=2.7 uM *
MANDSHURIN 10 ug/ml cow Okada,Y,et al.1995.Search for Naturally Occurring Substances to Prevent the Complications of Diabetes.II.Inhibitory Effect of Coumarin and Flavonoid Derivatives on Bovine Lens Aldose Reductase and Rabbit Platelet Aggregation.Chem Pharm Bull43(8):1385-1387
MANIFLAVONE Williamson, E. M. and Evans, F. J., Potter's New Cyclopaedia of Botanical Drugs and Preparations, Revised Ed., Saffron Walden, the C. W. Daniel Co., Ltd., Essex UK, 362 pp, 1988, reprint 1989.
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List of Activity Plants.
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Plant Name Common Name Chemical Count Total Parts Per Million
Borago officinalis Borage; Beebread; Beeplant; Talewort 4 50, 176
Boswellia sacra Olibanum; Frankincense; Olibanum Tree; Weihrauchbaum (Ger.); Weihrauchpflanze (Ger.); arbol del incensio (Sp.); Oliban (Sp.) 6 483, 000
Boswellia serrata Salaki; Salai Guggal; Kundur Luban; Salai; Indian Olibanum-Tree; Indian Frankincense 2 0
Bowdichia nitida 1 0
Brassica chinensis Chinese Cabbage; Pak-Choi; Chinese Mustard; Bok-Choy; Celery Mustard; Chinese White Cabbage; Celery Cabbage 1 67, 991
Brassica napus var. napobrassica Rutabaga; Swede; Swedish Turnip 1 7, 245
Brassica nigra Black Mustard 8 4, 013
Brassica oleracea Kohlrabi 4 7, 051.330000042915
Brassica oleracea var. botrytis l. Cauliflower 11 19, 770
Brassica oleracea var. capitata l. Cabbage; Red Cabbage; White Cabbage 9 22, 774.799999713898
Brassica oleracea var. gemmifera Brussels-Sprouts; Brussel-Sprout 5 12, 510
Brassica oleracea var. italica Broccoli; Heading Broccoli; Sprouting Broccoli; Cape Broccoli; Purple Cauliflower; Asparagus Broccoli; Winter Broccoli; Calabrese 11 83, 048
Brassica oleracea var. sabellica l. Kale; Curly Kale; Kitchen Kale; Scotch Kale 3 31, 732
Brassica oleracea var. viridis l. Collards; Cow Cabbage; Tall Kale; Tree Kale; Spring-Heading Cabbage 1 19, 095
Brassica pekinensis Chinese Cabbage 2 18
Brassica rapa Turnip; Seven-Top Turnip; Rapini 1 75, 731
Bromelia pinguin Wild Pineapple 1 3, 430
Brosimum alicastrum Breadnut; Tamamuri 1 3, 500
Brunfelsia uniflorus Manaca 1 0
Bupleurum chinense Chai-Hu 1 1, 200