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Dr. Duke's Phytochemical and Ethnobotanical Databases
U.S. Department of Agriculture
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Aldose-Reductase-Inhibitor

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List of activity chemicals.
Click on column headings to sort table by that column. *Unless otherwise noted all references are to (Duke, 1992)
Chemical Name Dosage Reference
KUWANON-C 100 uM Yamaguchi, T., Sato, J., Mihashi, H., Nomura, T. 1991. Aldose Reductase Inhibitors Containing Benzopyrans for Treatment of Diseases Associated with Diabetes. Patent, Japan Kokai Tokkyo Koho-03 68,517. 9pp.
LICORICIDIN 100 uM Yamaguchi, T., Sato, J., Mihashi, H., Nomura, T. 1991. Aldose Reductase Inhibitors Containing Benzopyrans for Treatment of Diseases Associated with Diabetes. Patent, Japan Kokai Tokkyo Koho-03 68,517. 9pp.
LICURASIDE IC50=0.56 uM *
LINARIIN IC18=10uM Shimizu, M., Ito, T., Terashima, S., Hayashi, T., Arisawa, M., Morita, N., Kurokawa, S., Ito, K., and Hashimoto, Y. 1984. Inhibition of Lens Aldose Reductase by Flavonoids. Phytochemistry, 23: 1885-1888.
LINARIN IC20=10 uM Shimizu, M., Ito, T., Terashima, S., Hayashi, T., Arisawa, M., Morita, N., Kurokawa, S., Ito, K., and Hashimoto, Y. 1984. Inhibition of Lens Aldose Reductase by Flavonoids. Phytochemistry, 23: 1885-1888.
LONICERIN IC56=1uM; IC92=10uM Shimizu, M., Ito, T., Terashima, S., Hayashi, T., Arisawa, M., Morita, N., Kurokawa, S., Ito, K., and Hashimoto, Y. 1984. Inhibition of Lens Aldose Reductase by Flavonoids. Phytochemistry, 23: 1885-1888.
LUTEOLIN EC=3 ppm Shin*, K.H., Chung, M.S., Chae, Y.J., Yoon, K.Y., Cho, T.S. 1992. A survey for aldose reductase inhibition of herbal medicines. Fitoterapia 64(2): 130, 1993.
LUTEOLIN IC50=0.45 uM rat *
LUTEOLIN-7-GLUCOSIDE IC73=10 uM *
LUTEOLIN-7-GLUCOSIDE IC31=1 uM Shimizu, M., Ito, T., Terashima, S., Hayashi, T., Arisawa, M., Morita, N., Kurokawa, S., Ito, K., and Hashimoto, Y. 1984. Inhibition of Lens Aldose Reductase by Flavonoids. Phytochemistry, 23: 1885-1888.
LUTEOLIN-7-GLUCURONIDE IC68=1 uM Shimizu, M., Ito, T., Terashima, S., Hayashi, T., Arisawa, M., Morita, N., Kurokawa, S., Ito, K., and Hashimoto, Y. 1984. Inhibition of Lens Aldose Reductase by Flavonoids. Phytochemistry, 23: 1885-1888.
LUTEOLIN-7-GLUCURONIDE IC88=10 uM *
LUTEOLIN-7-O-BETA-D-GLUCOPYRANOSIDURONIC-ACID IC50=3.1 uM rat Yoshikawa, M., et al. 1999. Medicinal Flowers. I. Aldose Reductase Inhibitors and Three New Eudesmane-Type Sesquiterpenes, Kikkanols A, B, and C, From the Flowers of Chrysanthemum inducum L. Chem Pharm Bull, 47(3): 340-345.
MACROCARPAL-A IC50=2 uM *
MACROCARPAL-A IC50=10 uM *
MACROCARPAL-B IC50=2.8 uM *
MACROCARPAL-D IC50=2 uM *
MACROCARPAL-G IC50=2.7 uM *
MANDSHURIN 10 ug/ml cow Okada,Y,et al.1995.Search for Naturally Occurring Substances to Prevent the Complications of Diabetes.II.Inhibitory Effect of Coumarin and Flavonoid Derivatives on Bovine Lens Aldose Reductase and Rabbit Platelet Aggregation.Chem Pharm Bull43(8):1385-1387
MANIFLAVONE Williamson, E. M. and Evans, F. J., Potter's New Cyclopaedia of Botanical Drugs and Preparations, Revised Ed., Saffron Walden, the C. W. Daniel Co., Ltd., Essex UK, 362 pp, 1988, reprint 1989.
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List of Activity Plants.
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Plant Name Common Name Chemical Count Total Parts Per Million
Chamaecytisus smyrnaeus 1 0
Chamaecytisus supinus 1 0
Chamaemelum nobile Garden Camomile; Perennial Camomile; Roman Camomile 12 801
Chamaespartium sagittale 1 0
Chamaespartium tridentatum 1 0
Chelidonium majus Celandine 2 0
Chenopodium album Lambsquarter 3 9, 000
Chenopodium ambrosioides Epazote; Wormseed 3 2, 040
Chimaphila umbellata King's Cure; Pipsissewa 3 0
Chondrus crispus Irish Moss 1 130
Chronanthus biflorus 1 0
Chrysanthemum coronarium Garland Chrysanthemum 1 9, 130
Chrysanthemum parthenium Feverfew 6 735.5
Chrysanthemum x morifolium Chrysanthemum; Florist's Chrysanthemum; Mum; Ju Hua (Pinyin) 8 624
Chrysobalanus icaco Cocoa plum; Icaco 1 2, 840
Chrysophyllum cainito Caimito; Star Apple 1 1, 280
Cicer arietinum Chickpea; Garbanzo 2 204.1999969482422
Cichorium endivia Endive; Escarole 3 18, 604
Cichorium intybus Chicory; Witloof; Succory 15 131, 644.5
Cimicifuga dahurica Sheng Ma 1 0