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Dr. Duke's Phytochemical and Ethnobotanical Databases
U.S. Department of Agriculture
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Quinone-Reductase-Inducer

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List of activity chemicals.
Click on column headings to sort table by that column. *Unless otherwise noted all references are to (Duke, 1992)
Chemical Name Dosage Reference
GLUCONASTURTIN 15 uM Tawfig,N. Heaney,R.K.,Plumb,J.A.,Fenwick,G.R.,Musk,S.R.R.,Williamson,G.1995. Dietary Glucosinolates as Blocking Agents Against Carcinogenesis: Glucosinolate Breakdown Products Assessed Induction of Quinone Reductase Activity I.Carcinogenesis 16(5)119-1194
GLUCORAPHANIN 1 uM Fahey, J. W., Zhang, Y., Talalay, P. 1997. Broccoli Sprouts: An Exceptionally Rich Source of Inducers of Enzymes that Protects Against Chemical Carcinogens. Proc. Nat. Acad. Sci., 94: 10367-10372.
IBERIN 2.4 uM Zhang, Y., Talalay, P., Cho, C. G., Posner, G. H. 1992. A Major Inducer of Anticarcinogenic Protective Enzymes from Broccoli: Isolation and Elucidation of Structure. Proc. Nat. Acad. Sci., 89: 2399-2403.
IBERVERIN 3.5 uM Zhang, Y., Talalay, P., Cho, C. G., Posner, G. H. 1992. A Major Inducer of Anticarcinogenic Protective Enzymes from Broccoli: Isolation and Elucidation of Structure. Proc. Nat. Acad. Sci., 89: 2399-2403.
INDOLE-3-CARBINOL 50 mg/kg igs mus Shertzer, H. G., Sainsbury, M. 1991. Intrinsic Acute Toxicity and Hepatic Enzyme Inducing Properties of the Chemoprotectants Indole-3-carbinol and 5,10-dihydroindeno[1,2-b]indole in... Fold Chem Toxicol, 29(4): 237-242.
IRILONE *
ISORHAMNETIN Yannai, S., Day, A. J., Williamson, G., Rhodes, M. J. C. 1998. Characterization of Flavonoids as Monofunctional or Bifunctional Inducers of Quinone Reductase in Murine Hepatoma Cell Lines. Food Chem Toxicol, 36(8): 623-630.
JUGLONE 20 uM Duhaiman, A. S. 1996. Characterization of Zeta-Crystallin Inhibition by Juglone. Biochem. Biophys. Res. Commun., 218(3): 648-652.
KAEMPFERIDE Yannai, S., Day, A. J., Williamson, G., Rhodes, M. J. C. 1998. Characterization of Flavonoids as Monofunctional or Bifunctional Inducers of Quinone Reductase in Murine Hepatoma Cell Lines. Food Chem Toxicol, 36(8): 623-630.
KAEMPFEROL 3 uM *
L-MAACKIAIN IC50=>13.4 uM *
LANCEOLATIN-B IC50=>76.3 uM *
LANCEOLATIN-B 22.9 uM *
LUTEIN 2.5 ug Madhavi, D. L., Bomser, J., Smith, M., Singletary, K. 1998. Isolation of Bioactive Constituents from Vaccinium myrtillus (Bilberry) Fruits and Cell Cultures. Plant Sci., 131(1): 95-103.
MEDICARPIN IC50>74.8 uM *
MYRICETIN 36 uM Uda, Y., Price, K. R., Williamson, G., Rhodes, M. J. C. 1997. Induction of the Anticarcinogenic Marker Enzyme, Quinone Reductase, in Murine Hepatoma Cells In Vitro by Flavonoids. Cancer Lett., 120 (2): 213-216.
NEOGLUCOBRASSICIN 100 uM Fahey, J. W., Zhang, Y., Talalay, P. 1997. Broccoli Sprouts: An Exceptionally Rich Source of Inducers of Enzymes that Protects Against Chemical Carcinogens. Proc. Nat. Acad. Sci., 94: 10367-10372.
PHENETHYL-ISOTHIOCYANATE 1 uM/kg Guo, Z., et al. 1992. Effects of Phenethyl Isothiocyanate, a Carcinogenesis Inhibitor, on Xenobiotic-Metabolizing Enzymes and Nitrosamine Metabolism in Rats. Carcinogenesis, 13(12): 2205-2210.
PONGAMOL ED50=6.1 uM *
PONGAMOL IC50=18.7 uM *
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List of Activity Plants.
Click on column headings to sort table by that column.
Plant Name Common Name Chemical Count Total Parts Per Million
Asparagus officinalis Asparagus 4 0
Astragalus membranaceus Huang-Chi; Huang Qi 3 0
Avena sativa Oats 1 620
Averrhoa carambola Carambola; Star Fruit 1 0
Azadirachta indica Neem 3 5, 000
Ballota nigra Black Horehound 1 0
Baptisia sp 1 0
Baptisia tinctoria Wild Indigo 1 0
Barosma betulina Buchu 1 0
Basella alba Vinespinach 1 0
Berberis vulgaris Barberry 5 0
Bertholletia excelsa Brazilnut; Brazilnut-Tree; Creamnut; Paranut 1 0
Beta vulgaris Beet; Beetroot; Sugar Beet; Garden Beet 2 0
Bixa orellana Achiote; Annatto; Annato; Lipsticktree; Lipstick Pod; Bija; Annoto; Arnato 3 0
Borago officinalis Borage; Beebread; Beeplant; Talewort 2 0
Bowdichia nitida 1 0
Brassica juncea Mustard Greens 4 0
Brassica napus var. napobrassica Rutabaga; Swede; Swedish Turnip 3 0
Brassica nigra Black Mustard 3 12, 000
Brassica oleracea Kohlrabi 4 120