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Biological Activity Quinone-Reductase-Inducer

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List of activity chemicals.
Click on column headings to sort table by that column. *Unless otherwise noted all references are to (Duke, 1992)
Chemical Name Sort descending Dosage Reference
GLUCONASTURTIN 15 uM Tawfig,N. Heaney,R.K.,Plumb,J.A.,Fenwick,G.R.,Musk,S.R.R.,Williamson,G.1995. Dietary Glucosinolates as Blocking Agents Against Carcinogenesis: Glucosinolate Breakdown Products Assessed Induction of Quinone Reductase Activity I.Carcinogenesis 16(5)119-1194
GLUCORAPHANIN 1 uM Fahey, J. W., Zhang, Y., Talalay, P. 1997. Broccoli Sprouts: An Exceptionally Rich Source of Inducers of Enzymes that Protects Against Chemical Carcinogens. Proc. Nat. Acad. Sci., 94: 10367-10372.
IBERIN 2.4 uM Zhang, Y., Talalay, P., Cho, C. G., Posner, G. H. 1992. A Major Inducer of Anticarcinogenic Protective Enzymes from Broccoli: Isolation and Elucidation of Structure. Proc. Nat. Acad. Sci., 89: 2399-2403.
IBERVERIN 3.5 uM Zhang, Y., Talalay, P., Cho, C. G., Posner, G. H. 1992. A Major Inducer of Anticarcinogenic Protective Enzymes from Broccoli: Isolation and Elucidation of Structure. Proc. Nat. Acad. Sci., 89: 2399-2403.
INDOLE-3-CARBINOL 50 mg/kg igs mus Shertzer, H. G., Sainsbury, M. 1991. Intrinsic Acute Toxicity and Hepatic Enzyme Inducing Properties of the Chemoprotectants Indole-3-carbinol and 5,10-dihydroindeno[1,2-b]indole in... Fold Chem Toxicol, 29(4): 237-242.
IRILONE not available Duke, 1992 *
ISORHAMNETIN not available Yannai, S., Day, A. J., Williamson, G., Rhodes, M. J. C. 1998. Characterization of Flavonoids as Monofunctional or Bifunctional Inducers of Quinone Reductase in Murine Hepatoma Cell Lines. Food Chem Toxicol, 36(8): 623-630.
JUGLONE 20 uM Duhaiman, A. S. 1996. Characterization of Zeta-Crystallin Inhibition by Juglone. Biochem. Biophys. Res. Commun., 218(3): 648-652.
KAEMPFERIDE not available Yannai, S., Day, A. J., Williamson, G., Rhodes, M. J. C. 1998. Characterization of Flavonoids as Monofunctional or Bifunctional Inducers of Quinone Reductase in Murine Hepatoma Cell Lines. Food Chem Toxicol, 36(8): 623-630.
KAEMPFEROL 3 uM Duke, 1992 *
L-MAACKIAIN IC50=>13.4 uM Duke, 1992 *
LANCEOLATIN-B IC50=>76.3 uM Duke, 1992 *
LANCEOLATIN-B 22.9 uM Duke, 1992 *
LUTEIN 2.5 ug Madhavi, D. L., Bomser, J., Smith, M., Singletary, K. 1998. Isolation of Bioactive Constituents from Vaccinium myrtillus (Bilberry) Fruits and Cell Cultures. Plant Sci., 131(1): 95-103.
MEDICARPIN IC50>74.8 uM Duke, 1992 *
MYRICETIN 36 uM Uda, Y., Price, K. R., Williamson, G., Rhodes, M. J. C. 1997. Induction of the Anticarcinogenic Marker Enzyme, Quinone Reductase, in Murine Hepatoma Cells In Vitro by Flavonoids. Cancer Lett., 120 (2): 213-216.
NEOGLUCOBRASSICIN 100 uM Fahey, J. W., Zhang, Y., Talalay, P. 1997. Broccoli Sprouts: An Exceptionally Rich Source of Inducers of Enzymes that Protects Against Chemical Carcinogens. Proc. Nat. Acad. Sci., 94: 10367-10372.
PHENETHYL-ISOTHIOCYANATE 1 uM/kg Guo, Z., et al. 1992. Effects of Phenethyl Isothiocyanate, a Carcinogenesis Inhibitor, on Xenobiotic-Metabolizing Enzymes and Nitrosamine Metabolism in Rats. Carcinogenesis, 13(12): 2205-2210.
PONGAMOL IC50=18.7 uM Duke, 1992 *
PONGAMOL ED50=6.1 uM Duke, 1992 *
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List of Activity Plants.
Click on column headings to sort table by that column.
Plant Name Sort descending Common Name Chemical Count Total Parts Per Million
Citrullus lanatus Watermelon 1 3
Citrus aurantium Petitgrain; Bitter Orange 1 0
Citrus limon Lemon 4 1.2000000476837158
Citrus paradisi Grapefruit 5 0.949999988079071
Citrus reticulata Mandarin; Tangerine 2 4
Citrus sinensis Orange 5 12.300000190734863
Citrus spp Citrus 2 0
Clitoria falcata not available 1 0
Clitoria ternatea not available 1 25
Cnicus benedictus Blessed Thistle 1 0
Cola acuminata Abata Cola 1 0
Colchicum autumnale Autumn Crocus; Meadow Saffron 1 0
Cologana broussonetii not available 1 0
Commiphora wightii Guggul; Indian Bdellium-Tree 2 0
Consolida ajacis Larkspur 2 0
Convallaria majalis Lily-Of-The-Valley 1 0
Conyza canadensis Butterweed; Hogweed; Horseweed 1 0
Coriandrum sativum Coriander; Chinese Parsley; Cilantro 3 0
Coriaria myrtifolia Mealy Tree 2 0
Coriaria thymifolia Ground Toot; Shanshi 2 0