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Dr. Duke's Phytochemical and Ethnobotanical Databases
U.S. Department of Agriculture
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Quinone-Reductase-Inducer

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List of activity chemicals.
Click on column headings to sort table by that column. *Unless otherwise noted all references are to (Duke, 1992)
Chemical Name Dosage Reference
GLUCONASTURTIN 15 uM Tawfig,N. Heaney,R.K.,Plumb,J.A.,Fenwick,G.R.,Musk,S.R.R.,Williamson,G.1995. Dietary Glucosinolates as Blocking Agents Against Carcinogenesis: Glucosinolate Breakdown Products Assessed Induction of Quinone Reductase Activity I.Carcinogenesis 16(5)119-1194
GLUCORAPHANIN 1 uM Fahey, J. W., Zhang, Y., Talalay, P. 1997. Broccoli Sprouts: An Exceptionally Rich Source of Inducers of Enzymes that Protects Against Chemical Carcinogens. Proc. Nat. Acad. Sci., 94: 10367-10372.
IBERIN 2.4 uM Zhang, Y., Talalay, P., Cho, C. G., Posner, G. H. 1992. A Major Inducer of Anticarcinogenic Protective Enzymes from Broccoli: Isolation and Elucidation of Structure. Proc. Nat. Acad. Sci., 89: 2399-2403.
IBERVERIN 3.5 uM Zhang, Y., Talalay, P., Cho, C. G., Posner, G. H. 1992. A Major Inducer of Anticarcinogenic Protective Enzymes from Broccoli: Isolation and Elucidation of Structure. Proc. Nat. Acad. Sci., 89: 2399-2403.
INDOLE-3-CARBINOL 50 mg/kg igs mus Shertzer, H. G., Sainsbury, M. 1991. Intrinsic Acute Toxicity and Hepatic Enzyme Inducing Properties of the Chemoprotectants Indole-3-carbinol and 5,10-dihydroindeno[1,2-b]indole in... Fold Chem Toxicol, 29(4): 237-242.
IRILONE *
ISORHAMNETIN Yannai, S., Day, A. J., Williamson, G., Rhodes, M. J. C. 1998. Characterization of Flavonoids as Monofunctional or Bifunctional Inducers of Quinone Reductase in Murine Hepatoma Cell Lines. Food Chem Toxicol, 36(8): 623-630.
JUGLONE 20 uM Duhaiman, A. S. 1996. Characterization of Zeta-Crystallin Inhibition by Juglone. Biochem. Biophys. Res. Commun., 218(3): 648-652.
KAEMPFERIDE Yannai, S., Day, A. J., Williamson, G., Rhodes, M. J. C. 1998. Characterization of Flavonoids as Monofunctional or Bifunctional Inducers of Quinone Reductase in Murine Hepatoma Cell Lines. Food Chem Toxicol, 36(8): 623-630.
KAEMPFEROL 3 uM *
L-MAACKIAIN IC50=>13.4 uM *
LANCEOLATIN-B IC50=>76.3 uM *
LANCEOLATIN-B 22.9 uM *
LUTEIN 2.5 ug Madhavi, D. L., Bomser, J., Smith, M., Singletary, K. 1998. Isolation of Bioactive Constituents from Vaccinium myrtillus (Bilberry) Fruits and Cell Cultures. Plant Sci., 131(1): 95-103.
MEDICARPIN IC50>74.8 uM *
MYRICETIN 36 uM Uda, Y., Price, K. R., Williamson, G., Rhodes, M. J. C. 1997. Induction of the Anticarcinogenic Marker Enzyme, Quinone Reductase, in Murine Hepatoma Cells In Vitro by Flavonoids. Cancer Lett., 120 (2): 213-216.
NEOGLUCOBRASSICIN 100 uM Fahey, J. W., Zhang, Y., Talalay, P. 1997. Broccoli Sprouts: An Exceptionally Rich Source of Inducers of Enzymes that Protects Against Chemical Carcinogens. Proc. Nat. Acad. Sci., 94: 10367-10372.
PHENETHYL-ISOTHIOCYANATE 1 uM/kg Guo, Z., et al. 1992. Effects of Phenethyl Isothiocyanate, a Carcinogenesis Inhibitor, on Xenobiotic-Metabolizing Enzymes and Nitrosamine Metabolism in Rats. Carcinogenesis, 13(12): 2205-2210.
PONGAMOL ED50=6.1 uM *
PONGAMOL IC50=18.7 uM *
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List of Activity Plants.
Click on column headings to sort table by that column.
Plant Name Common Name Chemical Count Total Parts Per Million
Canavalia gladiata 1 0
Canavalia rosea 1 0
Canavalia sericea 1 0
Canavalia virosa 1 0
Capparis spinosa Caper; Caperbush 3 0
Capsella bursa-pastoris Shepherd's Purse 2 0
Capsicum annuum Bell Pepper; Green Pepper; Cherry Pepper; Sweet Pepper; Cone Pepper; Paprika 3 9, 456
Capsicum frutescens Cayenne; Chili; Tabasco; Hot Pepper; Spur Pepper; Red Chili 4 756
Carica papaya Papaya 1 0
Carum carvi Caraway; Carum; Kummel (Ger.); Comino (Sp.); Comino de prado (Sp.) 2 0
Castanea sativa European Chestnut 3 0
Catalpa bignonioides Indian bean 1 0
Catharanthus roseus Madagascar Periwinkle; Rosy Periwinkle 3 0
Cedrus deodora Deodar Cedar 1 0
Ceiba pentandra Kapok; Silk-Cotton Tree 2 0
Centaurea calcitrapa Star-Thistle 2 0
Centaurea cyanus Cornflower; Bachelor's Button 4 0
Centella asiatica Gotu Kola; Pennywort 2 0
Centrosema pascuorum 1 0
Centrosema plumieri 1 0