Biological Activity Quinone-Reductase-Inducer | Dr. Duke's Phytochemical and Ethnobotanical Databases

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List of activity chemicals.
Click on column headings to sort table by that column. *Unless otherwise noted all references are to (Duke, 1992)
Chemical Name	Dosage	Reference
(+)-PURPURIN	ED50=5.6 uM	Duke, 1992 *
(+)-TEPHROPURPURIN	ED50=0.15 uM	Duke, 1992 *
(+)-TEPHROPURPURIN	IC50 13.4 uM	Duke, 1992 *
(-)-3-HYDROXY-4-METHOXY-8,9-METHYLENEDIOXYPTEROCARPAN	IC50=>63.7 uM	Duke, 1992 *
(-)-MAACKIAIN	ED50=8.8 uM	Duke, 1992 *
(-)-MEDICARPIN	ED50=13.7 uM	Duke, 1992 *
(1'S)-1'-ACETOXYCHAVICOL-ACETATE	not available	Duke, 1992 *
24,25-DIHYDROWITHANOLIDE-D	ED50=0.7 uM	Kennelly, E. J., Gerhauser, C., Song, L. L., Graham, J. G., Beecher, C. W. W., Pezzuto, J. M., Kinghorn, A. D. 1997. Induction of Quinone Reductase by Withanolides Isolated from Physalis philadelphica (Tomatillos). J. Agr. & Food Chem., 45(10): 3771-3777.
3-METHOXY-2,3-DIHYDROWITHAPHYSACARPIN	ED50=7.8 uM	Kennelly, E. J., Gerhauser, C., Song, L. L., Graham, J. G., Beecher, C. W. W., Pezzuto, J. M., Kinghorn, A. D. 1997. Induction of Quinone Reductase by Withanolides Isolated from Physalis philadelphica (Tomatillos). J. Agr. & Food Chem., 45(10): 3771-3777.
4',7-DIHYDROXY-3',5'-DIMETHOXYISOFLAVONE	ED50=17.2 uM	Duke, 1992 *
4-HYDROXY-GLUCOBRASSICIN	100 uM	Fahey, J. W., Zhang, Y., Talalay, P. 1997. Broccoli Sprouts: An Exceptionally Rich Source of Inducers of Enzymes that Protects Against Chemical Carcinogens. Proc. Nat. Acad. Sci., 94: 10367-10372.
6-METHYL-SULFINYL-HEXYL-ISOTHIOCYANATE	not available	Fuke, Y., Haga, Y., Ono, H., Nomura, T., Ryoyama, K. 1998. Anti-Carcinogenic Activity of 6-methylsulfinylhexyl isothiocyanate, an Active Anti-Proliferative Principle of Wasabi (Eutrema wasabi Maxim.). Cytotechnology, 25: 197-203.
7,4'-DIHYDROXY-3',5'-DIMETHOXYISOFLAVONE	IC50>63.7 uM	Duke, 1992 *
ALYSSIN	0.95 uM	Duke, 1992 *
APIGENIN	20 uM	Uda, Y., Price, K. R., Williamson, G., Rhodes, M. J. C. 1997. Induction of the Anticarcinogenic Marker Enzyme, Quinone Reductase, in Murine Hepatoma Cells In Vitro by Flavonoids. Cancer Lett., 120 (2): 213-216.
AURAPTENE	100 ppm	Duke, 1992 *
AURAPTENE	400 mg/kg igs rat	Tanaka,T. et al.1998.Citrus Auraptene Exerts Dose-Dependent Chemopreventive Activity in Rat Large Bowel Tumorigenesis:The Inhibition Correlates with Suppression of Cell Proliferation & Lipid Peroxidation & with Induction of Phase II-. Cancer Res.58:2550.
BAICALIN	not available	Duke, 1992 *
BERTEROIN	1.7 uM	Zhang, Y., Talalay, P., Cho, C. G., Posner, G. H. 1992. A Major Inducer of Anticarcinogenic Protective Enzymes from Broccoli: Isolation and Elucidation of Structure. Proc. Nat. Acad. Sci., 89: 2399-2403.
BIS-DEMETHOXYCURCUMIN	11.9 uM	Singletary, K., et al. 1998. Effect of the Beta-Diketones Diferoloylmethane (Curcumin) and Dibenzoylmethane on Rat Mammary DNA Adducts and Tumors Induced by 7,12-dimethylbenz(A)anthracene. Carcinogenesis, 19(6): 1039-1043.

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List of Activity Plants.
Click on column headings to sort table by that column.
Plant Name	Common Name	Chemical Count	Total Parts Per Million
Asparagus officinalis	Asparagus	4	0
Astragalus membranaceus	Huang-Chi; Huang Qi	3	0
Avena sativa	Oats	1	620
Averrhoa carambola	Carambola; Star Fruit	1	0
Azadirachta indica	Neem	3	5, 000
Ballota nigra	Black Horehound	1	0
Baptisia sp	not available	1	0
Baptisia tinctoria	Wild Indigo	1	0
Barosma betulina	Buchu	1	0
Basella alba	Vinespinach	1	0
Berberis vulgaris	Barberry	5	0
Bertholletia excelsa	Brazilnut; Brazilnut-Tree; Creamnut; Paranut	1	0
Beta vulgaris	Beet; Beetroot; Sugar Beet; Garden Beet	2	0
Bixa orellana	Achiote; Annatto; Annato; Lipsticktree; Lipstick Pod; Bija; Annoto; Arnato	3	0
Borago officinalis	Borage; Beebread; Beeplant; Talewort	2	0
Bowdichia nitida	not available	1	0
Brassica juncea	Mustard Greens	4	0
Brassica napus var. napobrassica	Rutabaga; Swede; Swedish Turnip	3	0
Brassica nigra	Black Mustard	3	12, 000
Brassica oleracea	Kohlrabi	4	120