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Dr. Duke's Phytochemical and Ethnobotanical Databases
U.S. Department of Agriculture
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MDR-Inhibitor

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List of activity chemicals.
Click on column headings to sort table by that column. *Unless otherwise noted all references are to (Duke, 1992)
Chemical Name Dosage Reference
ARTEMISININ IC50=2 uM *
BRAZILIN 50 mg/kg ipr mus Choi, S. Y., Yang, K. M., Jeon, S. D., Kim, J. H., Khil, L. Y., Chang, T. S., Moon, C. K. 1997. Brazilin Modulates Immune Function Mainly by Augmenting T-Cell Activity in Halothane Administered Mice. Planta Medica, 63: 405-408.
BREVIFOLIOL 1 ug/mL Kobayashi, J., et al. 1997. Effects of Taxoids From Taxus cuspidata on Microtubule Depolymerization and Vincristine Accumulation in MDR Cells. Bioorg. Med. Chem. Lett., 7: 393-398.
CELAFOLIN-A1 IC50=1.45 uM Kim, S. E., Kim, Y. H., Lee, J. J., Kim, Y. C. 1998. A New Sesquiterpene Ester From Celastrus orbiculatus Reversing Multidrug Resistance in Cancer Cells. J. Nat. Prod., 61(1): 108-111.
CELAFOLIN-A1 IC50=0.77 uM Kim, S. E., Kim, Y. H., Lee, J. J., Kim, Y. C. 1998. A New Sesquiterpene Ester From Celastrus orbiculatus Reversing Multidrug Resistance in Cancer Cells. J. Nat. Prod., 61(1): 108-111.
CELORBICOL-ESTER IC50=1.36 uM Kim, S. E., Kim, Y. H., Lee, J. J., Kim, Y. C. 1998. A New Sesquiterpene Ester From Celastrus orbiculatus Reversing Multidrug Resistance in Cancer Cells. J. Nat. Prod., 61(1): 108-111.
CHALCONE 100 uM Critchfield, J. W., Welsh, C. J., Phang, J. M., Yeh, G. C. 1994. Modulation of Adriamycin Accumulation and Efflux by Flavonoids in HCT-15 Colon Cells. Activation of P-Glycoprotein as a Putative Mechanism. Biochem Pharmacol, 48(7): 1437-1445.
CINCHONINE 250 mg/kg igs rat Genne, P., Duchamp, O., Solary, E., Magnette, J., Belon, J. P., Chauffert, B. 1995. Cinchonine Per OS: Efficient Circumvention of P-Glycoprotein-Mediated Multidrug Resistance. Anticancer Drug Design, 10(2): 103-118.
CINCHONINE 5 uM *
COLCHICEINE ED50=15 ng/ml Tang-Wai, D. F., Brossi, A., Arnold, L. D., Gros, P. 1993. The Nitrogen of the Acetamido Group of Colchicine Modulates P-Glycoprotein-Mediated Multidrug Resistance. Biochemistry, 32(25): 6470-6476.
COLCHICIDE ED50=410 ng/ml Tang-Wai, D. F., Brossi, A., Arnold, L. D., Gros, P. 1993. The Nitrogen of the Acetamido Group of Colchicine Modulates P-Glycoprotein-Mediated Multidrug Resistance. Biochemistry, 32(25): 6470-6476.
CONODURAMINE IC50=0.6 ug/ml You, M., et al. 1994. Indole Alkaloids From Peschiera laeta That Enhance Vinblastine-Mediated Cytotoxicity With Multidrug-Resistant Cells. J. Nat. Prod., 57(11): 1517-1522.
CONOPHYLLINE-QUINONE Takahashi, K., Koyano, T., Komiyama, H., Kam, T. S. 1998. Conophylline Quinone as a New Antitumor Agent. Patent, Japan Kokai Tokkyo Koho-10 45,763. 5pp.
CORONARIDINE IC50=1.9 ug/ml You, M., et al. 1994. Indole Alkaloids From Peschiera laeta That Enhance Vinblastine-Mediated Cytotoxicity With Multidrug-Resistant Cells. J. Nat. Prod., 57(11): 1517-1522.
CURCUMIN 1-55 uM *
DEACETYL-COLCHICEINE ED50=27 ng/ml Tang-Wai, D. F., Brossi, A., Arnold, L. D., Gros, P. 1993. The Nitrogen of the Acetamido Group of Colchicine Modulates P-Glycoprotein-Mediated Multidrug Resistance. Biochemistry, 32(25): 6470-6476.
DECINNAMOYL-TAXAGIFINE 1 ug/mL Kobayashi, J., et al. 1997. Effects of Taxoids From Taxus cuspidata on Microtubule Depolymerization and Vincristine Accumulation in MDR Cells. Bioorg. Med. Chem. Lett., 7: 393-398.
DEMECOLCINE ED50=78 ng/ml Tang-Wai, D. F., Brossi, A., Arnold, L. D., Gros, P. 1993. The Nitrogen of the Acetamido Group of Colchicine Modulates P-Glycoprotein-Mediated Multidrug Resistance. Biochemistry, 32(25): 6470-6476.
DENDROAMIDE-A 5 uM Ogino, J., Moore, R. E., Patterson, G. M. L., Smith, C. D. 1996. Dendroamides, New Cyclic Hexapeptides From a Blue-Green Alga. Multidrug-Resistance Reversing Activity of Dendroamide A. J. Nat. Prod., 59(6): 581-586.
DIACETYLTAXININE-B 1 ug/mL Kobayashi, J., et al. 1997. Effects of Taxoids From Taxus cuspidata on Microtubule Depolymerization and Vincristine Accumulation in MDR Cells. Bioorg. Med. Chem. Lett., 7: 393-398.
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List of Activity Plants.
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Plant Name Common Name Chemical Count Total Parts Per Million
Adenocarpus decorticans 1 0
Adenocarpus foliolosus 1 0
Agathosma betulina Buchu; Honey Buchu; Mountain Buchu 1 1, 500
Albizia procera 1 0
Alchornea floribunda Niando 1 0
Amphicarpaea bracteata Hog Peanut 1 5
Amphicarpaea edgworthii 1 11
Apios americana 1 12
Argyrocytisus battandieri 1 0
Artemisia annua Qinghao; Sweet Annie; Annual Mugwort (GRIN); Annual Wormwood (GRIN); Sweet Wormwood (GRIN) 1 94, 000
Aspidosperma quebracho-blanco Quebracho 1 0
Baptisia sp 1 0
Baptisia tinctoria Wild Indigo 1 0
Barosma betulina Buchu 1 500
Bowdichia nitida 1 0
Cajanus cajan Pigeonpea 1 0
Cajanus scarabaeoides 1 3
Calicotome spinosa 1 0
Calicotome villosa 1 0
Calopogonium caeruleum 1 0