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Dr. Duke's Phytochemical and Ethnobotanical Databases
U.S. Department of Agriculture
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MDR-Inhibitor

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List of activity chemicals.
Click on column headings to sort table by that column. *Unless otherwise noted all references are to (Duke, 1992)
Chemical Name Dosage Reference
ARTEMISININ IC50=2 uM *
BRAZILIN 50 mg/kg ipr mus Choi, S. Y., Yang, K. M., Jeon, S. D., Kim, J. H., Khil, L. Y., Chang, T. S., Moon, C. K. 1997. Brazilin Modulates Immune Function Mainly by Augmenting T-Cell Activity in Halothane Administered Mice. Planta Medica, 63: 405-408.
BREVIFOLIOL 1 ug/mL Kobayashi, J., et al. 1997. Effects of Taxoids From Taxus cuspidata on Microtubule Depolymerization and Vincristine Accumulation in MDR Cells. Bioorg. Med. Chem. Lett., 7: 393-398.
CELAFOLIN-A1 IC50=0.77 uM Kim, S. E., Kim, Y. H., Lee, J. J., Kim, Y. C. 1998. A New Sesquiterpene Ester From Celastrus orbiculatus Reversing Multidrug Resistance in Cancer Cells. J. Nat. Prod., 61(1): 108-111.
CELAFOLIN-A1 IC50=1.45 uM Kim, S. E., Kim, Y. H., Lee, J. J., Kim, Y. C. 1998. A New Sesquiterpene Ester From Celastrus orbiculatus Reversing Multidrug Resistance in Cancer Cells. J. Nat. Prod., 61(1): 108-111.
CELORBICOL-ESTER IC50=1.36 uM Kim, S. E., Kim, Y. H., Lee, J. J., Kim, Y. C. 1998. A New Sesquiterpene Ester From Celastrus orbiculatus Reversing Multidrug Resistance in Cancer Cells. J. Nat. Prod., 61(1): 108-111.
CHALCONE 100 uM Critchfield, J. W., Welsh, C. J., Phang, J. M., Yeh, G. C. 1994. Modulation of Adriamycin Accumulation and Efflux by Flavonoids in HCT-15 Colon Cells. Activation of P-Glycoprotein as a Putative Mechanism. Biochem Pharmacol, 48(7): 1437-1445.
CINCHONINE 5 uM *
CINCHONINE 250 mg/kg igs rat Genne, P., Duchamp, O., Solary, E., Magnette, J., Belon, J. P., Chauffert, B. 1995. Cinchonine Per OS: Efficient Circumvention of P-Glycoprotein-Mediated Multidrug Resistance. Anticancer Drug Design, 10(2): 103-118.
COLCHICEINE ED50=15 ng/ml Tang-Wai, D. F., Brossi, A., Arnold, L. D., Gros, P. 1993. The Nitrogen of the Acetamido Group of Colchicine Modulates P-Glycoprotein-Mediated Multidrug Resistance. Biochemistry, 32(25): 6470-6476.
COLCHICIDE ED50=410 ng/ml Tang-Wai, D. F., Brossi, A., Arnold, L. D., Gros, P. 1993. The Nitrogen of the Acetamido Group of Colchicine Modulates P-Glycoprotein-Mediated Multidrug Resistance. Biochemistry, 32(25): 6470-6476.
CONODURAMINE IC50=0.6 ug/ml You, M., et al. 1994. Indole Alkaloids From Peschiera laeta That Enhance Vinblastine-Mediated Cytotoxicity With Multidrug-Resistant Cells. J. Nat. Prod., 57(11): 1517-1522.
CONOPHYLLINE-QUINONE Takahashi, K., Koyano, T., Komiyama, H., Kam, T. S. 1998. Conophylline Quinone as a New Antitumor Agent. Patent, Japan Kokai Tokkyo Koho-10 45,763. 5pp.
CORONARIDINE IC50=1.9 ug/ml You, M., et al. 1994. Indole Alkaloids From Peschiera laeta That Enhance Vinblastine-Mediated Cytotoxicity With Multidrug-Resistant Cells. J. Nat. Prod., 57(11): 1517-1522.
CURCUMIN 1-55 uM *
DEACETYL-COLCHICEINE ED50=27 ng/ml Tang-Wai, D. F., Brossi, A., Arnold, L. D., Gros, P. 1993. The Nitrogen of the Acetamido Group of Colchicine Modulates P-Glycoprotein-Mediated Multidrug Resistance. Biochemistry, 32(25): 6470-6476.
DECINNAMOYL-TAXAGIFINE 1 ug/mL Kobayashi, J., et al. 1997. Effects of Taxoids From Taxus cuspidata on Microtubule Depolymerization and Vincristine Accumulation in MDR Cells. Bioorg. Med. Chem. Lett., 7: 393-398.
DEMECOLCINE ED50=78 ng/ml Tang-Wai, D. F., Brossi, A., Arnold, L. D., Gros, P. 1993. The Nitrogen of the Acetamido Group of Colchicine Modulates P-Glycoprotein-Mediated Multidrug Resistance. Biochemistry, 32(25): 6470-6476.
DENDROAMIDE-A 5 uM Ogino, J., Moore, R. E., Patterson, G. M. L., Smith, C. D. 1996. Dendroamides, New Cyclic Hexapeptides From a Blue-Green Alga. Multidrug-Resistance Reversing Activity of Dendroamide A. J. Nat. Prod., 59(6): 581-586.
DIACETYLTAXININE-B 1 ug/mL Kobayashi, J., et al. 1997. Effects of Taxoids From Taxus cuspidata on Microtubule Depolymerization and Vincristine Accumulation in MDR Cells. Bioorg. Med. Chem. Lett., 7: 393-398.
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List of Activity Plants.
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Plant Name Common Name Chemical Count Total Parts Per Million
Cologana broussonetii 1 0
Conium maculatum Poison Hemlock; Hemlock; Spotted Hemlock; Fool's Parsley; Carrot Fern; Spotted Parsley 1 240, 000
Costus speciosus Crepe Ginger; Wild Ginger; Cane Reed 1 0
Crotalaria juncea Sunhemp 1 0
Curcuma longa Turmeric; Indian Saffron 1 463, 600
Curcuma xanthorrhiza Javan Turmeric; Temu Lawak 1 20, 000
Curcuma zedoaria Shoti; Zedoary 1 2, 000
Cytisus ardoini 1 0
Cytisus ingramii 1 0
Cytisus multiflorus 1 0
Cytisus scoparius Scotch Broom 1 0
Cytisus striatus 1 0
Cytisus tribracteolatus 1 0
Desmodium gangeticum 1 8
Dictamnus albus Akgiritotu; Burning Bush; Dittany; Gas Plant; Gazelotu 1 0
Dioclea glycinoides 1 15
Dipogon lignosus 1 0
Dolichos biflorus 1 0
Dunbaria villosa 1 13
Echinospartium horridum 1 0