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Dr. Duke's Phytochemical and Ethnobotanical Databases
U.S. Department of Agriculture
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MDR-Inhibitor

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List of activity chemicals.
Click on column headings to sort table by that column. *Unless otherwise noted all references are to (Duke, 1992)
Chemical Name Dosage Reference
ARTEMISININ IC50=2 uM *
BRAZILIN 50 mg/kg ipr mus Choi, S. Y., Yang, K. M., Jeon, S. D., Kim, J. H., Khil, L. Y., Chang, T. S., Moon, C. K. 1997. Brazilin Modulates Immune Function Mainly by Augmenting T-Cell Activity in Halothane Administered Mice. Planta Medica, 63: 405-408.
BREVIFOLIOL 1 ug/mL Kobayashi, J., et al. 1997. Effects of Taxoids From Taxus cuspidata on Microtubule Depolymerization and Vincristine Accumulation in MDR Cells. Bioorg. Med. Chem. Lett., 7: 393-398.
CELAFOLIN-A1 IC50=0.77 uM Kim, S. E., Kim, Y. H., Lee, J. J., Kim, Y. C. 1998. A New Sesquiterpene Ester From Celastrus orbiculatus Reversing Multidrug Resistance in Cancer Cells. J. Nat. Prod., 61(1): 108-111.
CELAFOLIN-A1 IC50=1.45 uM Kim, S. E., Kim, Y. H., Lee, J. J., Kim, Y. C. 1998. A New Sesquiterpene Ester From Celastrus orbiculatus Reversing Multidrug Resistance in Cancer Cells. J. Nat. Prod., 61(1): 108-111.
CELORBICOL-ESTER IC50=1.36 uM Kim, S. E., Kim, Y. H., Lee, J. J., Kim, Y. C. 1998. A New Sesquiterpene Ester From Celastrus orbiculatus Reversing Multidrug Resistance in Cancer Cells. J. Nat. Prod., 61(1): 108-111.
CHALCONE 100 uM Critchfield, J. W., Welsh, C. J., Phang, J. M., Yeh, G. C. 1994. Modulation of Adriamycin Accumulation and Efflux by Flavonoids in HCT-15 Colon Cells. Activation of P-Glycoprotein as a Putative Mechanism. Biochem Pharmacol, 48(7): 1437-1445.
CINCHONINE 250 mg/kg igs rat Genne, P., Duchamp, O., Solary, E., Magnette, J., Belon, J. P., Chauffert, B. 1995. Cinchonine Per OS: Efficient Circumvention of P-Glycoprotein-Mediated Multidrug Resistance. Anticancer Drug Design, 10(2): 103-118.
CINCHONINE 5 uM *
COLCHICEINE ED50=15 ng/ml Tang-Wai, D. F., Brossi, A., Arnold, L. D., Gros, P. 1993. The Nitrogen of the Acetamido Group of Colchicine Modulates P-Glycoprotein-Mediated Multidrug Resistance. Biochemistry, 32(25): 6470-6476.
COLCHICIDE ED50=410 ng/ml Tang-Wai, D. F., Brossi, A., Arnold, L. D., Gros, P. 1993. The Nitrogen of the Acetamido Group of Colchicine Modulates P-Glycoprotein-Mediated Multidrug Resistance. Biochemistry, 32(25): 6470-6476.
CONODURAMINE IC50=0.6 ug/ml You, M., et al. 1994. Indole Alkaloids From Peschiera laeta That Enhance Vinblastine-Mediated Cytotoxicity With Multidrug-Resistant Cells. J. Nat. Prod., 57(11): 1517-1522.
CONOPHYLLINE-QUINONE Takahashi, K., Koyano, T., Komiyama, H., Kam, T. S. 1998. Conophylline Quinone as a New Antitumor Agent. Patent, Japan Kokai Tokkyo Koho-10 45,763. 5pp.
CORONARIDINE IC50=1.9 ug/ml You, M., et al. 1994. Indole Alkaloids From Peschiera laeta That Enhance Vinblastine-Mediated Cytotoxicity With Multidrug-Resistant Cells. J. Nat. Prod., 57(11): 1517-1522.
CURCUMIN 1-55 uM *
DEACETYL-COLCHICEINE ED50=27 ng/ml Tang-Wai, D. F., Brossi, A., Arnold, L. D., Gros, P. 1993. The Nitrogen of the Acetamido Group of Colchicine Modulates P-Glycoprotein-Mediated Multidrug Resistance. Biochemistry, 32(25): 6470-6476.
DECINNAMOYL-TAXAGIFINE 1 ug/mL Kobayashi, J., et al. 1997. Effects of Taxoids From Taxus cuspidata on Microtubule Depolymerization and Vincristine Accumulation in MDR Cells. Bioorg. Med. Chem. Lett., 7: 393-398.
DEMECOLCINE ED50=78 ng/ml Tang-Wai, D. F., Brossi, A., Arnold, L. D., Gros, P. 1993. The Nitrogen of the Acetamido Group of Colchicine Modulates P-Glycoprotein-Mediated Multidrug Resistance. Biochemistry, 32(25): 6470-6476.
DENDROAMIDE-A 5 uM Ogino, J., Moore, R. E., Patterson, G. M. L., Smith, C. D. 1996. Dendroamides, New Cyclic Hexapeptides From a Blue-Green Alga. Multidrug-Resistance Reversing Activity of Dendroamide A. J. Nat. Prod., 59(6): 581-586.
DIACETYLTAXININE-B 1 ug/mL Kobayashi, J., et al. 1997. Effects of Taxoids From Taxus cuspidata on Microtubule Depolymerization and Vincristine Accumulation in MDR Cells. Bioorg. Med. Chem. Lett., 7: 393-398.
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List of Activity Plants.
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Plant Name Common Name Chemical Count Total Parts Per Million
Hedeoma pulegioides American Pennyroyal 1 10, 000
Hyssopus officinalis Hyssop 1 60, 000
Kennedia coccinea 1 49
Kennedia nigricans 1 24
Kennedia procurrens 1 33
Kennedia rubicunda 1 25
Laburnum alpinum 1 0
Laburnum anagyroides Golden Chain Tree 1 0
Lembotropis emerifolia 1 0
Lens culinaris Lentil 1 25
Lespedeza cyrtobotrya 1 0
Lupinus albus White Lupine 1 0
Lupinus luteus 1 0
Lupinus perennis 1 0
Lygos monosperma 1 0
Lygos raetum 1 0
Maackia amurensis 1 0
Macroptylium atropurpureum 1 0
Macroptylium bracteatum 1 5
Macroptylium lathyroides 1 0