Chemical CINCHONINE | Dr. Duke's Phytochemical and Ethnobotanical Databases

Dr. Duke's Phytochemical and Ethnobotanical Databases

U.S. Department of Agriculture

Chemical ID

CINCHONINE

Ubiquitous

No

List of known dosages
Dosage
LD50=152 (ipr rat)

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List of chemical activities.
Click on column headings to sort table by that column. *Unless otherwise noted all references are to (Duke, 1992)
Activity	Dosage	Reference
Antiaggregant	IC50=125-180 uM	Duke, 1992 *
Antimalarial	LD50=152 (ipr rat)	Merck 11th Edition
Antipyretic	not available	=ICMR(Indian Council of Medical Research).1976.Medicinal Plants of India.Vol.1.Indian Council of Med. Res.Cambridge Printing Works, New Delhi.487 pp;ICMR.1987.Medicinal Plants of India.Vol.2.Indian Council of Med. Res.Cambr. Printing Works,New Delhi.600pp
MDR-Inhibitor	250 mg/kg igs rat	Genne, P., Duchamp, O., Solary, E., Magnette, J., Belon, J. P., Chauffert, B. 1995. Cinchonine Per OS: Efficient Circumvention of P-Glycoprotein-Mediated Multidrug Resistance. Anticancer Drug Design, 10(2): 103-118.
MDR-Inhibitor	5 uM	Duke, 1992 *
PAF-Inhibitor	IC50=125-180 uM	Duke, 1992 *
Pesticide	not available	Duke, 1992 *

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List of chemical plants.
Click on column headings to sort table by that column. *Unless otherwise noted all references are to (Duke, 1992)
Plant Name	Plant Part	Low Parts Per Million	High Parts Per Million	Standard Deviation	Reference
Cinchona officinalis	Bark	not available	not available	not available	Duke, 1992 *
Cinchona spp	Bark	15000.0	80000.0	not available	Duke, 1992 *
Olea europaea	Leaf	not available	not available	not available	Rizk, A.F.M. and Al-Nowaihi, A.S., The Phytochemistry of the Horticultural Plants of Qatar, Scientific and Applied Research Centre, University of Qatar.