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Dr. Duke's Phytochemical and Ethnobotanical Databases
U.S. Department of Agriculture

Biological Activity MDR-Inhibitor

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List of activity chemicals.
Click on column headings to sort table by that column. *Unless otherwise noted all references are to (Duke, 1992)
Chemical Name Dosage Reference
DIOSMIN 100 uM Critchfield, J. W., Welsh, C. J., Phang, J. M., Yeh, G. C. 1994. Modulation of Adriamycin Accumulation and Efflux by Flavonoids in HCT-15 Colon Cells. Activation of P-Glycoprotein as a Putative Mechanism. Biochem Pharmacol, 48(7): 1437-1445.
GENISTEIN 200 uM Castro, A. F., Altenberg, G. A. 1997. Inhibition of Drug Transport by Genistein in Multidrug-Resistant Cell Expressing P-Glycoprotein. Biochem Pharmacol, 53(1): 89-93.
GINSENOSIDE-RB-1 100 uM cat Hasegawa,H.,Sung,J.H.,Matsumiya,S.,Uchiyama,M.,Inouye,Y.,Kasai,R.,Yamasaki,K. 1995. Reversal of Daunomycin and Vinblastine Resistance in Multidrug-Resistance P388 Leukemia in vitro through Enhanced Cytotoxicity by Triterpenoids. Planta Med, 61(5):409-413.
GINSENOSIDE-RB-2 100 uM Hasegawa,H.,Sung,J.H.,Matsumiya,S.,Uchiyama,M.,Inouye,Y.,Kasai,R.,Yamasaki,K. 1995. Reversal of Daunomycin and Vinblastine Resistance in Multidrug-Resistance P388 Leukemia in vitro through Enhanced Cytotoxicity by Triterpenoids. Planta Med, 61(5):409-413.
GINSENOSIDE-RC 100 uM Hasegawa,H.,Sung,J.H.,Matsumiya,S.,Uchiyama,M.,Inouye,Y.,Kasai,R.,Yamasaki,K. 1995. Reversal of Daunomycin and Vinblastine Resistance in Multidrug-Resistance P388 Leukemia in vitro through Enhanced Cytotoxicity by Triterpenoids. Planta Med, 61(5):409-413.
GINSENOSIDE-RD 50 uM Hasegawa,H.,Sung,J.H.,Matsumiya,S.,Uchiyama,M.,Inouye,Y.,Kasai,R.,Yamasaki,K. 1995. Reversal of Daunomycin and Vinblastine Resistance in Multidrug-Resistance P388 Leukemia in vitro through Enhanced Cytotoxicity by Triterpenoids. Planta Med, 61(5):409-413.
GINSENOSIDE-RE 100 uM Hasegawa,H.,Sung,J.H.,Matsumiya,S.,Uchiyama,M.,Inouye,Y.,Kasai,R.,Yamasaki,K. 1995. Reversal of Daunomycin and Vinblastine Resistance in Multidrug-Resistance P388 Leukemia in vitro through Enhanced Cytotoxicity by Triterpenoids. Planta Med, 61(5):409-413.
GINSENOSIDE-RF 100 uM Hasegawa,H.,Sung,J.H.,Matsumiya,S.,Uchiyama,M.,Inouye,Y.,Kasai,R.,Yamasaki,K. 1995. Reversal of Daunomycin and Vinblastine Resistance in Multidrug-Resistance P388 Leukemia in vitro through Enhanced Cytotoxicity by Triterpenoids. Planta Med, 61(5):409-413.
GINSENOSIDE-RF-1 100 uM Hasegawa,H.,Sung,J.H.,Matsumiya,S.,Uchiyama,M.,Inouye,Y.,Kasai,R.,Yamasaki,K. 1995. Reversal of Daunomycin and Vinblastine Resistance in Multidrug-Resistance P388 Leukemia in vitro through Enhanced Cytotoxicity by Triterpenoids. Planta Med, 61(5):409-413.
GINSENOSIDE-RF-2 25 uM Hasegawa,H.,Sung,J.H.,Matsumiya,S.,Uchiyama,M.,Inouye,Y.,Kasai,R.,Yamasaki,K. 1995. Reversal of Daunomycin and Vinblastine Resistance in Multidrug-Resistance P388 Leukemia in vitro through Enhanced Cytotoxicity by Triterpenoids. Planta Med, 61(5):409-413.
GINSENOSIDE-RG-1 100 uM Hasegawa,H.,Sung,J.H.,Matsumiya,S.,Uchiyama,M.,Inouye,Y.,Kasai,R.,Yamasaki,K. 1995. Reversal of Daunomycin and Vinblastine Resistance in Multidrug-Resistance P388 Leukemia in vitro through Enhanced Cytotoxicity by Triterpenoids. Planta Med, 61(5):409-413.
GINSENOSIDE-RG-2 100 uM Hasegawa,H.,Sung,J.H.,Matsumiya,S.,Uchiyama,M.,Inouye,Y.,Kasai,R.,Yamasaki,K. 1995. Reversal of Daunomycin and Vinblastine Resistance in Multidrug-Resistance P388 Leukemia in vitro through Enhanced Cytotoxicity by Triterpenoids. Planta Med, 61(5):409-413.
HAPALOSIN 20 uM Stratmann, K., Burgoyne, D. L., Moore, R. E., Patterson, G. M. L., Smith, C. D. 1994. Hapalosin, a Cyanobacterial Cyclic Depsipeptide With Multidrug-Resistance Reversing Activity. J Org Chem, 59(24): 7219-7226.
HOMOHARRINGTONINE Qian, Q. J., Han, J. L., Yan, W. W., Yang, C. Z., Han, D. S., Shi, H., Hao, Y. 1996. A Comparative Study on the Mechanism of Homoharringtonine (HHI) and Melphalan (MEL) Resistance in K562/H20 and K562/MEL Cell Lines. Zhonghua Xueyexue Zazhi,17(7):354-356.
INOSTAMYCIN 10 uM *
ISORESERPINE 1.6 uM Hall, A. M., Croy, V., Chan, T., Ruff, D., Kuczek, T., Chang, C. J. 1996. Bicinchoninic Acid Protein Assay in the Determination of Adriamycin Cytotoxicity Modulated by the MDR Glycoprotein. J Nat Prod, 59(1): 35-40.
KOPSAMINE IC50=5.6 ug/ml Kam, T. S., Subramaniam, G., Sim, K. M., Yoganathan, K., Koyano, T., Toyoshima, M., Rho, M. C., Hayashi, M., Komiyama, K. 1998. Reversal of Multidrug Resistance (MDR) by Aspidofractinine-Type Indole Alkaloids. Bioorg. Med. Chem. Lett., 8: 2769-2772.
KOPSIFLORINE IC50=5.6 ug/ml Kam, T. S., Subramaniam, G., Sim, K. M., Yoganathan, K., Koyano, T., Toyoshima, M., Rho, M. C., Hayashi, M., Komiyama, K. 1998. Reversal of Multidrug Resistance (MDR) by Aspidofractinine-Type Indole Alkaloids. Bioorg. Med. Chem. Lett., 8: 2769-2772.
KOPSILONGINE IC50=15.4 ug/ml Kam, T. S., Subramaniam, G., Sim, K. M., Yoganathan, K., Koyano, T., Toyoshima, M., Rho, M. C., Hayashi, M., Komiyama, K. 1998. Reversal of Multidrug Resistance (MDR) by Aspidofractinine-Type Indole Alkaloids. Bioorg. Med. Chem. Lett., 8: 2769-2772.
KOPSININE IC50=25 ug/ml Kam, T. S., Subramaniam, G., Sim, K. M., Yoganathan, K., Koyano, T., Toyoshima, M., Rho, M. C., Hayashi, M., Komiyama, K. 1998. Reversal of Multidrug Resistance (MDR) by Aspidofractinine-Type Indole Alkaloids. Bioorg. Med. Chem. Lett., 8: 2769-2772.
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List of Activity Plants.
Click on column headings to sort table by that column.
Plant Name Common Name Chemical Count Total Parts Per Million
Adenocarpus decorticans 1 0
Adenocarpus foliolosus 1 0
Agathosma betulina Buchu; Honey Buchu; Mountain Buchu 1 1, 500
Albizia procera 1 0
Alchornea floribunda Niando 1 0
Amphicarpaea bracteata Hog Peanut 1 5
Amphicarpaea edgworthii 1 11
Apios americana 1 12
Argyrocytisus battandieri 1 0
Artemisia annua Qinghao; Sweet Annie; Annual Mugwort (GRIN); Annual Wormwood (GRIN); Sweet Wormwood (GRIN) 1 94, 000
Aspidosperma quebracho-blanco Quebracho 1 0
Baptisia sp 1 0
Baptisia tinctoria Wild Indigo 1 0
Barosma betulina Buchu 1 500
Bowdichia nitida 1 0
Cajanus cajan Pigeonpea 1 0
Cajanus scarabaeoides 1 3
Calicotome spinosa 1 0
Calicotome villosa 1 0
Calopogonium caeruleum 1 0