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Dr. Duke's Phytochemical and Ethnobotanical Databases
U.S. Department of Agriculture
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COX-1-Inhibitor

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List of activity chemicals.
Click on column headings to sort table by that column. *Unless otherwise noted all references are to (Duke, 1992)
Chemical Name Dosage Reference
(+)-CATECHIN IC50=183-279 uM (cf indomethacin IC50=1 uM) *
(-)-EPIAFZELECHIN IC50=15 uM/ Min, K. R. et al. 1999. (-)-epiafzelechin: Cyclooxygenase-1 Inhibitor and Anti-Inflammatory Agent from Aerial Parts of Celastrus orbiculatus. Planta Med., 65(5): 460-462.
3,4-METHYLENE-DIOXYCINNAMIC-ACID-BORNYL-ESTER IC16=100 ug/ml *
AIPHANOL *
ANTHOCYANINS IC45=125 ug/ml *
APIGENIN IC65=1,000 uM *
BAICALEIN 100 ug/ml Fukutake, M., Yokota, S., Kawamura, H., Iizuka, A., Amagaya, S., Fukuda, K., Komatsu, Y. 1998. Inhibitory effect of Coptidis rhizoma adn Scutellariae radix on azoxymethane-induced aberrant crypt foci formation in rat colon. Biol Pharm Bull, 21(8): 814-817
BETA-CAROTENE IC78=50 ug/ml *
CATECHIN IC50=80 uM (cf indomethacin IC50=1 uM) *
CINNAMIC-ACID-BORNYL-ESTER IC66=100 ug/ml *
CIRSILINEOL IC37=1,000 uM *
CIRSIMARITIN IC50=1,000 uM *
CYANIDIN-3-O-GLUCOSIDE IC30=100 ug/ml *
DIRCA-PHENOLIC-GLUCOSIDE-5 125 ug/ml Ramsewak, R. S., Nair, M. G., De Witt, D. L., Mattson, W. G., Zasada, J. 1999. Phenolic Glycosides from Dirca palustris. J. Nat. Prod., 62(11): 1558-1561.
EUGENOL IC97=1,000 uM *
FLAVOKAWAIN-B IC77=100 ug/ml *
FLAVOKAWAIN-B IC55=12.5 ug/ml *
ISOTHYMONIN IC37=1,000 uM *
LAURIC-ACID IC40=100 *
MYRICETIN-3-O-BETA-D-GLUCURONIDE IC50=0.5 uM/ Hiermann, A., Schramm, H. W., Laufer, S. 1998. Anti-Inflammatory Activity of Myricetin-3--O-beta-d-glucuronide and Related Compounds. Inflamm. Res., 47(11): 421-427.
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List of Activity Plants.
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Plant Name Common Name Chemical Count Total Parts Per Million
Vaccinium macrocarpon Cranberry; Large Cranberry; American Cranberry 4 7.799999713897705
Vaccinium myrtillus Bilberry; Whortleberry; Dwarf Bilberry 6 2, 193.0299999993294
Vaccinium vitis-idaea Cowberry; Lingen; Lingonberry 2 10, 500
Valeriana officinalis Valerian; Common Valerian; Garden-Heliotrope 1 0
Vanilla planifolia Vanilla; Bourbon Vanilla 2 0
Verbascum thapsus Mullein; Velvetplant; Flannelleaf; Flannelplant; Great Mullein 1 215
Verbena officinalis Vervain 1 0
Viburnum opulus Crampbark; European Cranberry Bush; Guelder Rose; Snowballbush 1 25, 600
Vicia faba Broadbean; Faba Bean; Habas 1 34.800000071525574
Vigna aconitifolia Mat Bean; Moth Bean 1 0.4000000059604645
Vigna angularis Adzuki Bean 1 0.8999999761581421
Vigna mungo Black Gram 1 0.5
Vigna radiata Green Gram; Mungbean 1 5.200000047683716
Vigna subterranea Bambarra Groundnut; Groundbean 1 0.2199999988079071
Vigna unguiculata Cowpea; Black-eyed Pea; Crowder Pea; Southern Pea 1 352.7999991774559
Viola odorata Common Violet; Sweet Violet 1 714
Virola surinamensis Ucahuba; Ucuuba 1 230, 000
Viscum album European Mistletoe 1 0
Vitis vinifera Grape; European Grape; Wine Grape; Grapevine; Vigne Vinifere (Fr.); Weinrebe (Ger.); Parra (Sp.); Vid (Sp.) 7 1, 471, 026.4000015259
Xanthosoma sagittifolium Malanga; Tannia; Yautia 1 982.8000000715256