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Dr. Duke's Phytochemical and Ethnobotanical Databases
U.S. Department of Agriculture
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COX-1-Inhibitor

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List of activity chemicals.
Click on column headings to sort table by that column. *Unless otherwise noted all references are to (Duke, 1992)
Chemical Name Dosage Reference
(+)-CATECHIN IC50=183-279 uM (cf indomethacin IC50=1 uM) *
(-)-EPIAFZELECHIN IC50=15 uM/ Min, K. R. et al. 1999. (-)-epiafzelechin: Cyclooxygenase-1 Inhibitor and Anti-Inflammatory Agent from Aerial Parts of Celastrus orbiculatus. Planta Med., 65(5): 460-462.
3,4-METHYLENE-DIOXYCINNAMIC-ACID-BORNYL-ESTER IC16=100 ug/ml *
AIPHANOL *
ANTHOCYANINS IC45=125 ug/ml *
APIGENIN IC65=1,000 uM *
BAICALEIN 100 ug/ml Fukutake, M., Yokota, S., Kawamura, H., Iizuka, A., Amagaya, S., Fukuda, K., Komatsu, Y. 1998. Inhibitory effect of Coptidis rhizoma adn Scutellariae radix on azoxymethane-induced aberrant crypt foci formation in rat colon. Biol Pharm Bull, 21(8): 814-817
BETA-CAROTENE IC78=50 ug/ml *
CATECHIN IC50=80 uM (cf indomethacin IC50=1 uM) *
CINNAMIC-ACID-BORNYL-ESTER IC66=100 ug/ml *
CIRSILINEOL IC37=1,000 uM *
CIRSIMARITIN IC50=1,000 uM *
CYANIDIN-3-O-GLUCOSIDE IC30=100 ug/ml *
DIRCA-PHENOLIC-GLUCOSIDE-5 125 ug/ml Ramsewak, R. S., Nair, M. G., De Witt, D. L., Mattson, W. G., Zasada, J. 1999. Phenolic Glycosides from Dirca palustris. J. Nat. Prod., 62(11): 1558-1561.
EUGENOL IC97=1,000 uM *
FLAVOKAWAIN-B IC77=100 ug/ml *
FLAVOKAWAIN-B IC55=12.5 ug/ml *
ISOTHYMONIN IC37=1,000 uM *
LAURIC-ACID IC40=100 *
MYRICETIN-3-O-BETA-D-GLUCURONIDE IC50=0.5 uM/ Hiermann, A., Schramm, H. W., Laufer, S. 1998. Anti-Inflammatory Activity of Myricetin-3--O-beta-d-glucuronide and Related Compounds. Inflamm. Res., 47(11): 421-427.
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List of Activity Plants.
Click on column headings to sort table by that column.
Plant Name Common Name Chemical Count Total Parts Per Million
Syzygium jambos Pomarrosa; Rose Apple 1 17
Syzygium malaccense Malay Apple; Mammey Pomorrosa; Ohia 1 0.23999999463558197
Tabebuia heptaphylla Pau D'Arco 1 4.300000190734863
Tagetes erecta Marigold; Aztec Marigold 1 0
Tamarindus indica Tamarind; Kilytree; Indian Tamarind 2 363
Tanacetum parthenium Feverfew 2 1, 014
Tanacetum vulgare Tansy 1 0
Taraxacum officinale Dandelion 2 667
Taxus baccata Common Yew 1 0
Tecoma stans Yellow Elder 1 0
Terminalia arjuna Arjun; Arjuna 1 16.600000381469727
Terminalia catappa Indian Almond; Tropical Almond; Malabar Almond 2 5.3999998569488525
Terminalia pallida 1 1, 000
Tetragonia tetragonioides New Zealand Spinach 1 440
Teucrium polium Golden Germander 2 0
Teucrium scorodonia Germander; Wood Germander 1 0
Theobroma bicolor Nicaraguan Cacao; Pataste 1 18
Theobroma cacao Cacao 2 4, 000
Thuja occidentalis Arbor-Vitae; Northern White-Cedar 1 0
Thymus capitatus 'Sicilian' Thyme; Spanish Origanum; Spanish Thyme 1 63