An official website of the United States government.

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

Biological Activity COX-1-Inhibitor

List of activity chemicals.
Click on column headings to sort table by that column. *Unless otherwise noted all references are to (Duke, 1992)
Chemical Name Dosage Reference
(+)-CATECHIN IC50=183-279 uM (cf indomethacin IC50=1 uM) Duke, 1992 *
(-)-EPIAFZELECHIN IC50=15 uM/ Min, K. R. et al. 1999. (-)-epiafzelechin: Cyclooxygenase-1 Inhibitor and Anti-Inflammatory Agent from Aerial Parts of Celastrus orbiculatus. Planta Med., 65(5): 460-462.
3,4-METHYLENE-DIOXYCINNAMIC-ACID-BORNYL-ESTER IC16=100 ug/ml Duke, 1992 *
AIPHANOL not available Duke, 1992 *
ANTHOCYANINS IC45=125 ug/ml Duke, 1992 *
APIGENIN IC65=1,000 uM Duke, 1992 *
BAICALEIN 100 ug/ml Fukutake, M., Yokota, S., Kawamura, H., Iizuka, A., Amagaya, S., Fukuda, K., Komatsu, Y. 1998. Inhibitory effect of Coptidis rhizoma adn Scutellariae radix on azoxymethane-induced aberrant crypt foci formation in rat colon. Biol Pharm Bull, 21(8): 814-817
BETA-CAROTENE IC78=50 ug/ml Duke, 1992 *
CATECHIN IC50=80 uM (cf indomethacin IC50=1 uM) Duke, 1992 *
CINNAMIC-ACID-BORNYL-ESTER IC66=100 ug/ml Duke, 1992 *
CIRSILINEOL IC37=1,000 uM Duke, 1992 *
CIRSIMARITIN IC50=1,000 uM Duke, 1992 *
CYANIDIN-3-O-GLUCOSIDE IC30=100 ug/ml Duke, 1992 *
DIRCA-PHENOLIC-GLUCOSIDE-5 125 ug/ml Ramsewak, R. S., Nair, M. G., De Witt, D. L., Mattson, W. G., Zasada, J. 1999. Phenolic Glycosides from Dirca palustris. J. Nat. Prod., 62(11): 1558-1561.
EUGENOL IC97=1,000 uM Duke, 1992 *
FLAVOKAWAIN-B IC77=100 ug/ml Duke, 1992 *
FLAVOKAWAIN-B IC55=12.5 ug/ml Duke, 1992 *
ISOTHYMONIN IC37=1,000 uM Duke, 1992 *
LAURIC-ACID IC40=100 Duke, 1992 *
MYRICETIN-3-O-BETA-D-GLUCURONIDE IC50=0.5 uM/ Hiermann, A., Schramm, H. W., Laufer, S. 1998. Anti-Inflammatory Activity of Myricetin-3--O-beta-d-glucuronide and Related Compounds. Inflamm. Res., 47(11): 421-427.
List of Activity Plants.
Click on column headings to sort table by that column.
Plant Name Common Name Chemical Count Total Parts Per Million
Solanum nigrum Black Nightshade 1 110
Solanum quitoensis Naranjillo 1 16
Solanum sessiliflorum Cocona 1 14
Solanum torvum Susumba; Wild Eggplant 1 54
Solanum tuberosum Potato 2 143.00999999977648
Sonchus oleraceus Cerraja; Sow Thistle 1 1, 090
Sorbus aucubaria Rowan Berry 1 98
Spinacia oleracea Spinach 1 722.5
Spirulina pratensis Spirulina 1 478
Spirulina spp. Spirulina 1 480
Spondias dulcis Ambarella 1 16
Spondias mombin Yellow Mombin; Yellow Plum 1 230
Spondias pinnata Yellow Mombin; Yellow Plum 1 56
Spondias purpurea Purple Jobo; Purple Plum 1 18
Stachys officinalis Betony; Wood Betony; Bishop's-Wort; Purple Betony 3 0
Stellaria media Chickweed; Common Chickweed 3 86
Stevia rebaudiana Ca-A-E; Sweet Leaf of Paraguay; Stevia 2 225
Symphytum officinale Comfrey 2 5, 768
Syzygium aromaticum Clove; Clovetree 2 1, 780, 806
Syzygium cumini Aceituna Dulce; Jambolan; Java Plum 1 9