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Dr. Duke's Phytochemical and Ethnobotanical Databases
U.S. Department of Agriculture
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COX-1-Inhibitor

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List of activity chemicals.
Click on column headings to sort table by that column. *Unless otherwise noted all references are to (Duke, 1992)
Chemical Name Dosage Reference
(+)-CATECHIN IC50=183-279 uM (cf indomethacin IC50=1 uM) *
(-)-EPIAFZELECHIN IC50=15 uM/ Min, K. R. et al. 1999. (-)-epiafzelechin: Cyclooxygenase-1 Inhibitor and Anti-Inflammatory Agent from Aerial Parts of Celastrus orbiculatus. Planta Med., 65(5): 460-462.
3,4-METHYLENE-DIOXYCINNAMIC-ACID-BORNYL-ESTER IC16=100 ug/ml *
AIPHANOL *
ANTHOCYANINS IC45=125 ug/ml *
APIGENIN IC65=1,000 uM *
BAICALEIN 100 ug/ml Fukutake, M., Yokota, S., Kawamura, H., Iizuka, A., Amagaya, S., Fukuda, K., Komatsu, Y. 1998. Inhibitory effect of Coptidis rhizoma adn Scutellariae radix on azoxymethane-induced aberrant crypt foci formation in rat colon. Biol Pharm Bull, 21(8): 814-817
BETA-CAROTENE IC78=50 ug/ml *
CATECHIN IC50=80 uM (cf indomethacin IC50=1 uM) *
CINNAMIC-ACID-BORNYL-ESTER IC66=100 ug/ml *
CIRSILINEOL IC37=1,000 uM *
CIRSIMARITIN IC50=1,000 uM *
CYANIDIN-3-O-GLUCOSIDE IC30=100 ug/ml *
DIRCA-PHENOLIC-GLUCOSIDE-5 125 ug/ml Ramsewak, R. S., Nair, M. G., De Witt, D. L., Mattson, W. G., Zasada, J. 1999. Phenolic Glycosides from Dirca palustris. J. Nat. Prod., 62(11): 1558-1561.
EUGENOL IC97=1,000 uM *
FLAVOKAWAIN-B IC55=12.5 ug/ml *
FLAVOKAWAIN-B IC77=100 ug/ml *
ISOTHYMONIN IC37=1,000 uM *
LAURIC-ACID IC40=100 *
MYRICETIN-3-O-BETA-D-GLUCURONIDE IC50=0.5 uM/ Hiermann, A., Schramm, H. W., Laufer, S. 1998. Anti-Inflammatory Activity of Myricetin-3--O-beta-d-glucuronide and Related Compounds. Inflamm. Res., 47(11): 421-427.
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List of Activity Plants.
Click on column headings to sort table by that column.
Plant Name Common Name Chemical Count Total Parts Per Million
Thymus cilicicus 'Anatolian' Thyme 1 0.10000000149011612
Thymus funkii Funk's Thyme 1 5
Thymus serpyllum Creeping Thyme 2 23, 000
Thymus vulgaris Common Thyme; Garden Thyme; Thyme 8 204, 162
Tilia sp. Basswood; Lime; Linden 1 0
Tragopogon porrifolius Salsify 1 0.2680000066757202
Trichosanthes anguina Snakegourd 2 130, 018
Trifolium pratense Red Clover; Purple Clover; Peavine Clover; Cowgrass 3 48
Trigonella foenum-graecum Fenugreek; Greek Clover; Greek Hay; Bockshornklee (Ger.); Alholva (Sp.) 2 1, 391.0000000149012
Triticum aestivum Wheat 3 0.2199999988079071
Tropaeolum majus Nasturtium 1 665
Tropaeolum tuberosum Anu; Mashua 1 4.199999809265137
Turnera diffusa Damiana 1 71
Tussilago farfara Coltsfoot 1 0
Ulex europaeus Gorse 1 253
Ullucus tuberosus Melloco; Ulluco 1 1.399999976158142
Ulmus rubra Slippery Elm; Red Elm 1 50
Umbellularia californica California Bay 1 40
Urtica dioica European Nettle; Stinging Nettle 1 238
Vaccinium corymbosum Blueberry 5 3.920000094920397