Biological Activity Aldose-Reductase-Inhibitor | Dr. Duke's Phytochemical and Ethnobotanical Databases

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List of activity chemicals.
Click on column headings to sort table by that column. *Unless otherwise noted all references are to (Duke, 1992)
Chemical Name	Dosage	Reference
TRIFOLIN	IC62=10 uM	Shimizu, M., Ito, T., Terashima, S., Hayashi, T., Arisawa, M., Morita, N., Kurokawa, S., Ito, K., and Hashimoto, Y. 1984. Inhibition of Lens Aldose Reductase by Flavonoids. Phytochemistry, 23: 1885-1888.
TRIFOLIN	IC19=1 uM	Duke, 1992 *
UMBELLIFERONE	IC50=4.8 ug/ml cow	Okada,Y,et al.1995.Search for Naturally Occurring Substances to Prevent the Complications of Diabetes.II.Inhibitory Effect of Coumarin and Flavonoid Derivatives on Bovine Lens Aldose Reductase and Rabbit Platelet Aggregation.Chem Pharm Bull43(8):1385-1387
VANILLIC-ACID	100 uM/l	Duke, 1992 *
VERBASCOSIDE	IC50=0.39-15.1 uM	Duke, 1992 *
VITEXICARPIN	100 uM/l	Duke, 1992 *
VITEXIN	5 ug/ml	Okamot, Y., Yoshizawa, T. 1994. Angiotensin-Converting Enzyme Inhibitors and Aldose Reductase Inhibitors Containing Passiflora quadraqularis Extracts or Vitexin. Patent, Japan Kokai Tokkyo Koho-06,293,657. 4pp.
VITEXIN	IC15=10 uM	Shimizu, M., Ito, T., Terashima, S., Hayashi, T., Arisawa, M., Morita, N., Kurokawa, S., Ito, K., and Hashimoto, Y. 1984. Inhibition of Lens Aldose Reductase by Flavonoids. Phytochemistry, 23: 1885-1888.
WARANGALONE	10 uM	Iinuma, M., Tanaka, T., Mizuno, M., Katsuzaki, T., Ogawa, H. 1989. Structure-Activity Correlation of Flavonoids for Inhibition of Bovine Lens Aldose Reductase. Chem Pharm Bull, 37(7): 1813-1815.
WOGONIN	IC50=48 uM rat	Shin, K. H., Chae, Y. J., Chung, M. S., Lee, H. J. 1994. Effect of Flavonoids from Scutellariae radix on Cataract Formation and Polyol Accumulation in Rat Lens. Korean J Pharmacog, 25(1): 41-46.
WOGONIN	IC13=10uM	Shimizu, M., Ito, T., Terashima, S., Hayashi, T., Arisawa, M., Morita, N., Kurokawa, S., Ito, K., and Hashimoto, Y. 1984. Inhibition of Lens Aldose Reductase by Flavonoids. Phytochemistry, 23: 1885-1888.
WOGONIN-7-O-GLUCURONIDE	IC50=40 uM rat	Shin, K. H., Chae, Y. J., Chung, M. S., Lee, H. J. 1994. Effect of Flavonoids from Scutellariae radix on Cataract Formation and Polyol Accumulation in Rat Lens. Korean J Pharmacog, 25(1): 41-46.
WOGONIN-7-O-GLUCURONIDE-METHYL-ESTER	IC50=39 uM rat	Shin, K. H., Chae, Y. J., Chung, M. S., Lee, H. J. 1994. Effect of Flavonoids from Scutellariae radix on Cataract Formation and Polyol Accumulation in Rat Lens. Korean J Pharmacog, 25(1): 41-46.
XANTHOMICROL	10 uM	Okuda, I., Muwa, B., Inagakat, K., Horie, T., Nakayama, M. 1982. Inhibition of Aldose Reductases from Rat and Bovine Lenses by Flavonoids. Biochem Pharmacol, 31(23): 3807-3822.

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List of Activity Plants.
Click on column headings to sort table by that column.
Plant Name	Common Name	Chemical Count	Total Parts Per Million
Sonchus oleraceus	Cerraja; Sow Thistle	4	1, 250
Sophora japonica	Japanese Pagoda Tree	8	888, 470
Sophora subprostrata	Shan Dou Gen	1	0
Sorbus aucubaria	Rowan Berry	8	2, 650
Spartium junceum	Genet; Spanish Broom; Weaver's Broom	4	0
Spinacia oleracea	Spinach	10	11, 201
Spirulina pratensis	Spirulina	1	0
Spirulina spp.	Spirulina	1	0
Spondias dulcis	Ambarella	1	2, 750
Spondias mombin	Yellow Mombin; Yellow Plum	1	3, 230
Spondias pinnata	Yellow Mombin; Yellow Plum	1	4, 330
Spondias purpurea	Purple Jobo; Purple Plum	1	4, 050
Stachys germanica	Downy Woundwort	2	13
Stachys officinalis	Betony; Wood Betony; Bishop's-Wort; Purple Betony	5	20, 032
Stachys sieboldii	not available	1	0
Stachytarpheta cayennensis	Verbena	1	0
Stachytarpheta jamaicensis	Brazilian Tea	1	0
Stauracanthus boivinii	not available	1	0
Stauracanthus genistoides	not available	1	0
Stellaria media	Chickweed; Common Chickweed	9	138