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Dr. Duke's Phytochemical and Ethnobotanical Databases
U.S. Department of Agriculture
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Aldose-Reductase-Inhibitor

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List of activity chemicals.
Click on column headings to sort table by that column. *Unless otherwise noted all references are to (Duke, 1992)
Chemical Name Dosage Reference
MATTEUORIENATE-A IC50=1 uM Basnet, P., Kadota, S., Hase, K., Namba, T. 1995. Five New C-Methyl Flavonoids, the Potent Aldose Reductase Inhibitors from Matteuccia orientalis TREV. Chem Pharm Bull, 43(9): 1558-1564.
MATTEUORIENATE-B IC50=1 uM Basnet, P., Kadota, S., Hase, K., Namba, T. 1995. Five New C-Methyl Flavonoids, the Potent Aldose Reductase Inhibitors from Matteuccia orientalis TREV. Chem Pharm Bull, 43(9): 1558-1564.
MATTEUORIENATE-C IC50=2.3 uM Basnet, P., Kadota, S., Hase, K., Namba, T. 1995. Five New C-Methyl Flavonoids, the Potent Aldose Reductase Inhibitors from Matteuccia orientalis TREV. Chem Pharm Bull, 43(9): 1558-1564.
MEARNSITRIN IC50=1.4 uM Yoshikawa, M., et al. 1998. Antidiabetic Principles of Natural Medicines. II. Aldose Reductase and Alpha-Glucosidase Inhibitors from Brazilian Natural Medicine, the Leaves of Myrcia multiflora DC. (....). Chem Pharm Bull, 46(1): 113-119.
METHYL-ALPHA-D-GALACTOSIDE 0.1 mM/l rat (weak activity) Fujita, T., Ohira, K., Miyatake, K., Nakano, Y., Nakayama, M. 1995. Inhibitory Effect of Perillosides A and C, Related Monoterpene Glucosides on Aldose Reductase and Their Structure-Activity Relationships. Chem Pharm Bull, 43(6): 920-926.
METHYL-SCUTELLAREIN IC32=10uM Shimizu, M., Ito, T., Terashima, S., Hayashi, T., Arisawa, M., Morita, N., Kurokawa, S., Ito, K., and Hashimoto, Y. 1984. Inhibition of Lens Aldose Reductase by Flavonoids. Phytochemistry, 23: 1885-1888.
MORIN 100 uM Oliveira, T. T., Nagem, T. J., Miranda, L. C. G., Paula, V. F., Teixeira, M. A. 1997. Inhibitory Action on Aldose Reductase by Soybean Flavonoids. J Braz Chem Soc, 8(3): 211-213.
MYRCENE 100 ug/ml Okamura, K., Iwakami, S., Matsunaga, T. 1992. Biological Activity of Monoterpenes from Trees. Toyama-Ken Yakuji Kenkyusho Nenpo, (20): 95-101.
MYRCIACITRIN-I IC50=3.2 uM Yoshikawa, M., et al. 1998. Antidiabetic Principles of Natural Medicines. II. Aldose Reductase and Alpha-Glucosidase Inhibitors from Brazilian Natural Medicine, the Leaves of Myrcia multiflora DC. (....). Chem Pharm Bull, 46(1): 113-119.
MYRCIACITRIN-II IC50=15 uM Yoshikawa, M., et al. 1998. Antidiabetic Principles of Natural Medicines. II. Aldose Reductase and Alpha-Glucosidase Inhibitors from Brazilian Natural Medicine, the Leaves of Myrcia multiflora DC. (....). Chem Pharm Bull, 46(1): 113-119.
MYRCIAPHENONE-B IC50=29 uM Yoshikawa, M., et al. 1998. Antidiabetic Principles of Natural Medicines. II. Aldose Reductase and Alpha-Glucosidase Inhibitors from Brazilian Natural Medicine, the Leaves of Myrcia multiflora DC. (....). Chem Pharm Bull, 46(1): 113-119.
MYRICETIN-3-O-(4''-ACETYL)-ALPHA-FUCOSIDE IC50=17.9 uM Haraguchi, H., Kanada, M., Fukuda, A., Naruse, K., Okamura, N., Yagi, A. 1998. An Inhibitor of Aldose Reductase and Sorbitol Accumulation from Anthocepharus chinensis. Planta Med, 64(1): 68-69.
MYRICETIN-3-O-(4''-ACETYL)-ALPHA-FUCOSIDE IC50=10.7 uM Haraguchi, H., Kanada, M., Fukuda, A., Naruse, K., Okamura, N., Yagi, A. 1998. An Inhibitor of Aldose Reductase and Sorbitol Accumulation from Anthocepharus chinensis. Planta Med, 64(1): 68-69.
MYRICITRIN IC50=3.8 uM Yoshikawa, M., et al. 1998. Antidiabetic Principles of Natural Medicines. II. Aldose Reductase and Alpha-Glucosidase Inhibitors from Brazilian Natural Medicine, the Leaves of Myrcia multiflora DC. (....). Chem Pharm Bull, 46(1): 113-119.
NARINGENIN IC78=10 uM Shimizu, M., Ito, T., Terashima, S., Hayashi, T., Arisawa, M., Morita, N., Kurokawa, S., Ito, K., and Hashimoto, Y. 1984. Inhibition of Lens Aldose Reductase by Flavonoids. Phytochemistry, 23: 1885-1888.
NARINGENIN 100 uM Oliveira, T. T., Nagem, T. J., Miranda, L. C. G., Paula, V. F., Teixeira, M. A. 1997. Inhibitory Action on Aldose Reductase by Soybean Flavonoids. J Braz Chem Soc, 8(3): 211-213.
NARINGENIN 1 ug/mL Aida, K., Tawata, M., Shindo, H., Onaya, T., Sasaki, H., Yamaguchi, T., Chin, M.(Chen, Z.), and Mitsuhashi, H. 1989. Isoliquiritigenin: A New Aldose Reductase Inhibitor from Glycyrrhizae Radix. Planta Medica 56(3): 254-258.
NARINGENIN IC25=1 uM Shimizu, M., Ito, T., Terashima, S., Hayashi, T., Arisawa, M., Morita, N., Kurokawa, S., Ito, K., and Hashimoto, Y. 1984. Inhibition of Lens Aldose Reductase by Flavonoids. Phytochemistry, 23: 1885-1888.
NARINGIN Werbach, M. 1993. Healing with Food. Harper Collins, New York, 443 pp.
NELUMBOSIDE IC32=1uM; IC64=10uM Shimizu, M., Ito, T., Terashima, S., Hayashi, T., Arisawa, M., Morita, N., Kurokawa, S., Ito, K., and Hashimoto, Y. 1984. Inhibition of Lens Aldose Reductase by Flavonoids. Phytochemistry, 23: 1885-1888.
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List of Activity Plants.
Click on column headings to sort table by that column.
Plant Name Common Name Chemical Count Total Parts Per Million
Sonchus oleraceus Cerraja; Sow Thistle 4 1, 250
Sophora japonica Japanese Pagoda Tree 8 888, 470
Sophora subprostrata Shan Dou Gen 1 0
Sorbus aucubaria Rowan Berry 8 2, 650
Spartium junceum Genet; Spanish Broom; Weaver's Broom 4 0
Spinacia oleracea Spinach 10 11, 201
Spirulina pratensis Spirulina 1 0
Spirulina spp. Spirulina 1 0
Spondias dulcis Ambarella 1 2, 750
Spondias mombin Yellow Mombin; Yellow Plum 1 3, 230
Spondias pinnata Yellow Mombin; Yellow Plum 1 4, 330
Spondias purpurea Purple Jobo; Purple Plum 1 4, 050
Stachys germanica Downy Woundwort 2 13
Stachys officinalis Betony; Wood Betony; Bishop's-Wort; Purple Betony 5 20, 032
Stachys sieboldii 1 0
Stachytarpheta cayennensis Verbena 1 0
Stachytarpheta jamaicensis Brazilian Tea 1 0
Stauracanthus boivinii 1 0
Stauracanthus genistoides 1 0
Stellaria media Chickweed; Common Chickweed 9 138