An official website of the United States government.

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

Biological Activity Xanthine-Oxidase-Inhibitor

List of activity chemicals.
Click on column headings to sort table by that column. *Unless otherwise noted all references are to (Duke, 1992)
Chemical Name Dosage Reference
(+)-CATECHIN not available Mills, Simon and Bone, Kerry. 2000. Phytotherapy. Churchill
Livinston, Edinburgh.
(-)-EPICATECHIN IC50=>40 Hatano, T., Yasuhara, T., Yoshihara, R., Agata, I., Noro, T., and Okuda, T. 1989. Effects of Interaction of Tannins with Co-existing Substances.VII. Inhibitory Effects of Tannins Related Polyphenols on Xanthine Oxidase. Chem. Pharm. Bull. 38(5): 1224-1229
(-)-EPIGALLOCATECHIN IC50=>40 Hatano, T., Yasuhara, T., Yoshihara, R., Agata, I., Noro, T., and Okuda, T. 1989. Effects of Interaction of Tannins with Co-existing Substances.VII. Inhibitory Effects of Tannins Related Polyphenols on Xanthine Oxidase. Chem. Pharm. Bull. 38(5): 1224-1229
(-)-EPIGALLOCATECHIN-GALLATE IC50=>40 Hatano, T., Yasuhara, T., Yoshihara, R., Agata, I., Noro, T., and Okuda, T. 1989. Effects of Interaction of Tannins with Co-existing Substances.VII. Inhibitory Effects of Tannins Related Polyphenols on Xanthine Oxidase. Chem. Pharm. Bull. 38(5): 1224-1229
(1'S)-1'-ACETOXYCHAVICOL-ACETATE not available Duke, 1992 *
(Z,E)-2-(3,4-DIHYDROXYPHENYL)-ETHENYL-ESTER IC50=0.021 ug/ml Chem. & Pharm. Bull. 38: 1772.
(Z,E)-2-(3,5-DIHYDROXYPHENYL)-ETHENYL-ESTER IC50=0.124 ug/ml Chem. & Pharm. Bull. 38: 1772.
1,2,3,6-TETRA-O-GALLYOL-BETA-D-GLUCOSE IC50=12 uM Hatano, T., Yasuhara, T., Yoshihara, R., Agata, I., Noro, T., and Okuda, T. 1989. Effects of Interaction of Tannins with Co-existing Substances.VII. Inhibitory Effects of Tannins Related Polyphenols on Xanthine Oxidase. Chem. Pharm. Bull. 38(5): 1224-1229
1,2,6-TRI-O-GALLOYL-BETA-D-GLUCOSE IC50=39 uM Hatano, T., Yasuhara, T., Yoshihara, R., Agata, I., Noro, T., and Okuda, T. 1989. Effects of Interaction of Tannins with Co-existing Substances.VII. Inhibitory Effects of Tannins Related Polyphenols on Xanthine Oxidase. Chem. Pharm. Bull. 38(5): 1224-1229
1,3,4,6-TETRA-O-GALLOYL-BETA-D-GLUCOSE IC50=8 uM Hatano, T., Yasuhara, T., Yoshihara, R., Agata, I., Noro, T., and Okuda, T. 1989. Effects of Interaction of Tannins with Co-existing Substances.VII. Inhibitory Effects of Tannins Related Polyphenols on Xanthine Oxidase. Chem. Pharm. Bull. 38(5): 1224-1229
3,5-DI-O-CAFFEOYLQUINIC-ACID IC50=34 uM Hatano, T., Yasuhara, T., Yoshihara, R., Agata, I., Noro, T., and Okuda, T. 1989. Effects of Interaction of Tannins with Co-existing Substances.VII. Inhibitory Effects of Tannins Related Polyphenols on Xanthine Oxidase. Chem. Pharm. Bull. 38(5): 1224-1229
3-O-GALLOYLEPICATECHINS IC50=4-7 Hatano, T., Yasuhara, T., Yoshihara, R., Agata, I., Noro, T., and Okuda, T. 1989. Effects of Interaction of Tannins with Co-existing Substances.VII. Inhibitory Effects of Tannins Related Polyphenols on Xanthine Oxidase. Chem. Pharm. Bull. 38(5): 1224-1229
AESCULETIN IC52=10 uM Duke, 1992 *
ALLICIN 500 uM LAWSON in Koch, H. P. and Lawson, L. D., eds. 1996. Garlic- The
Science and therapeutic application of Allium sativum L. and related species. Williams & Wilkins, Baltimore. 329 pp.
ALLOPURINOL 0.021 ug/ml Duke, 1992 *
ALLOPURINOL IC50=0.17 uM Hatano, T., Yasuhara, T., Yoshihara, R., Agata, I., Noro, T., and Okuda, T. 1989. Effects of Interaction of Tannins with Co-existing Substances.VII. Inhibitory Effects of Tannins Related Polyphenols on Xanthine Oxidase. Chem. Pharm. Bull. 38(5): 1224-1229
APIGENIN 0.36 uM Duke, 1992 *
ASTRAGALIN-2''-GALLATE 50 uM Duke, 1992 *
ASTRAGALIN-6''-GALLATE 50 uM Duke, 1992 *
ATHYRIOL not available Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp.
List of Activity Plants.
Click on column headings to sort table by that column.
Plant Name Common Name Chemical Count Total Parts Per Million
Rhynchosia minima Burn Mouth Vine 1 0
Ribes nigrum Black Currant 4 13, 800
Ribes uva-crispa Gooseberry 2 0
Ricinus communis Castorbean 5 0
Robinia pseudoacacia Black Locust 1 70, 000
Rosa canina Rose; Dogbrier; Dog Rose 7 60, 090
Rosa centifolia Cabbage Rose 1 0
Rosa damascena Damask Rose 1 0
Rosa gallica French Rose 1 0
Rosa laevigata Cherokee Rose 1 0
Rosa multiflora Multiflora Rose 2 0
Rosa rubiginosa Rosa Mosqueta 1 26, 400
Rosa spp Rose Hips 2 26, 400
Rosmarinus officinalis Rosemary 5 0
Rubus fruticosus Blackberry 1 0
Rubus idaeus Red Raspberry; Raspberry 8 252, 500
Rubus phoenicolasius Wineberry; Wine Raspberry; Japanese Wineberry 2 0
Rubus sp. not available 2 0
Rumex acetosa Garden Sorrel 2 500
Rumex acetosella Sheep Sorrel 1 140, 000