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Dr. Duke's Phytochemical and Ethnobotanical Databases
U.S. Department of Agriculture
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Topoisomerase-I-Inhibitor

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List of activity chemicals.
Click on column headings to sort table by that column. *Unless otherwise noted all references are to (Duke, 1992)
Chemical Name Dosage Reference
CAFFEINE 75 uM Shin, C. G., Strayer, J. M., Wani, M., Snapka, R. M. 1990. Rapid Evaluation of Topoisomerase Inhibitors: Caffeine Inhibition of Topoisomerases in vivo. Teratogen Carcinogen Mutagen, 10: 41-52.
CAFFEINE 0.1 nM Tohda, H., Zhao, J. H., Oikawa, A. 1992. A Possible Involvement of DNA Topoisomerase I in 'Caffeine Effect' After Ultraviolet Irradiation. Tohoku J Exp Med, 168: 129-132.
CAMPTOTHECIN 1-50 uM *
CAMPTOTHECIN IC50=670 nM Luzzio, M. J., et al. 1995. Synthesis and Antitumor Activity of Novel Water Soluble Derivatives of Camptothecin as Specific Inhibitors of Topoisomerase I. J Med Chem, 38: 395-401.
CAMPTOTHECIN IC50=1 uM Weller, M., et al. 1997. Topoisomerase I Inhibitors For Human Malignant Glioma: Differential Modulation of P53, P21, BAX and BEL-2 Expression and of CD95-Mediated Apoptosis. Int J Cancer, 73: 707-714.
CAMPTOTHECIN ED50=0.8 uM Hertzberg, R. P., et al. 1989. Modification of the Hydroxy Lactone Ring of Camptothecin: Inhibition of Mammalian topoisomerase I and Biological Activity. J Med Chem, 32: 715-720.
CHARTREUSIN 1 ug/mL Yoshida, T., Habuka, N., Takeuchi, M., Ichishima, E. 1986. Inhibition of DNA Topoisomerase I From Alcaligenes sp. by Chartreusin. Agr Biol Chem, 50: 515-516.
CHEBULAGIC-ACID IC50=50 nM *
CHEBULANIN MIC=0.1 ug/ml Tokura, K., Kagawa, S. 1993. Anticancer Agents Containing Chebulanin From Terminalia chebula. Patent, Japan Kokai Tokkyo Koho-07 138,165. 4pp.
CHELERYTHRINE Fang, S. D., Wang, L. K., Hect, S. M. 1993. Inhibitors of DNA Topoisomerase I Isolated From the Roots of Zanthoxylum nitidum. J Org Chem, 58: 5025-5027.
CHRYSIN Santti, R., Makela, S., Strauss, L., Korman, J., Kostian, M. L. 1998. Phytoestrogens: Potential Endocrine Disruptors in Males. Toxicol Ind Health, 14: 223-237.
CORILAGIN IC50=40 uM Hecht, S. M., Berry, D. E., MacKenzie, L. J., Busby, R. W., Nasuti, C. A. 1992. A Strategy For Identifying Novel, Mechanistically Unique Inhibitors of Topoisomerase I. J Natural Products, 55: 401-413.
CRYPTOLEPINE 5 uM Bonjean, K., et al. 1998. The DNA Intercalating Alkaloid Cryptolepine Interferes with Topoisomerase II and Inhibits Primarily DNA Synthesis in B16 Melanoma Cell. Biochemistry, 37: 5136-5146.
CURCUMIN *
DAIDZEIN Santti, R., Makela, S., Strauss, L., Korman, J., Kostian, M. L. 1998. Phytoestrogens: Potential Endocrine Disruptors in Males. Toxicol Ind Health, 14: 223-237.
DEMETHOXYCURCUMIN *
DIHYDRODAIDZEIN 250 ppm (weak activity) Chang, Y. C., Nair, M. G., Nitiss, L. J. L. 1995. MEtabolites of Daidzein and Genistein and Their Biological Activities. J Natural Products, 58: 1901-1905.
DIHYDROGENISTEIN 250 ppm Chang, Y. C., Nair, M. G., Nitiss, L. J. L. 1995. MEtabolites of Daidzein and Genistein and Their Biological Activities. J Natural Products, 58: 1901-1905.
DIHYDROTANSHINONE-I 1 uM Lee, D. S., Lee, S. H., Kwon, G. S., Lee, H. K., Woo, J. H., Kim, J. G., Hong, S. D. 1999. Inhibition of DNA Topoisomerase I by Dihydrotanshinone I, Components of a Medicinal Herb Salvia miltiorrhiza Bunge. Biosci. Biotech. Biochem., 63: 1370-1373.
DISTAMYCIN Mortensen, U. H., Stevensner, T., Krogh, S., Olesen, K., Westergard, O., Bonven, B. J. 1990. Distamycin Inhibition of Topoisomerase I-DNA Intercation: A Mechanistic Analysis. Nucleic Acids Res, 18: 1983-1989.
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List of Activity Plants.
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Plant Name Common Name Chemical Count Total Parts Per Million
Artemisia annua Qinghao; Sweet Annie; Annual Mugwort (GRIN); Annual Wormwood (GRIN); Sweet Wormwood (GRIN) 4 0
Artemisia dracunculus Tarragon 5 97
Artocarpus altilis Breadfruit 1 0
Artocarpus heterophyllus Jackfruit 1 0
Asimina triloba Pawpaw 1 0
Aspalathus linearis Rooibos; Kaffree Tea; Red Bush Tea 3 264, 055.7999997139
Asparagus officinalis Asparagus 2 0
Astragalus membranaceus Huang-Chi; Huang Qi 3 0
Avena sativa Oats 1 620
Azadirachta indica Neem 3 5, 000
Ballota nigra Black Horehound 2 0
Baptisia sp 1 0
Baptisia tinctoria Wild Indigo 3 0
Barosma betulina Buchu 1 0
Basella alba Vinespinach 1 0
Berberis vulgaris Barberry 2 0
Beta vulgaris Beet; Beetroot; Sugar Beet; Garden Beet 2 0
Bocconia arborea Tree Poppy 1 0
Bocconia frutescens Tree Poppy 1 0
Borago officinalis Borage; Beebread; Beeplant; Talewort 2 0