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Dr. Duke's Phytochemical and Ethnobotanical Databases
U.S. Department of Agriculture
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Topoisomerase-I-Inhibitor

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List of activity chemicals.
Click on column headings to sort table by that column. *Unless otherwise noted all references are to (Duke, 1992)
Chemical Name Dosage Reference
CAFFEINE 0.1 nM Tohda, H., Zhao, J. H., Oikawa, A. 1992. A Possible Involvement of DNA Topoisomerase I in 'Caffeine Effect' After Ultraviolet Irradiation. Tohoku J Exp Med, 168: 129-132.
CAFFEINE 75 uM Shin, C. G., Strayer, J. M., Wani, M., Snapka, R. M. 1990. Rapid Evaluation of Topoisomerase Inhibitors: Caffeine Inhibition of Topoisomerases in vivo. Teratogen Carcinogen Mutagen, 10: 41-52.
CAMPTOTHECIN 1-50 uM *
CAMPTOTHECIN IC50=670 nM Luzzio, M. J., et al. 1995. Synthesis and Antitumor Activity of Novel Water Soluble Derivatives of Camptothecin as Specific Inhibitors of Topoisomerase I. J Med Chem, 38: 395-401.
CAMPTOTHECIN IC50=1 uM Weller, M., et al. 1997. Topoisomerase I Inhibitors For Human Malignant Glioma: Differential Modulation of P53, P21, BAX and BEL-2 Expression and of CD95-Mediated Apoptosis. Int J Cancer, 73: 707-714.
CAMPTOTHECIN ED50=0.8 uM Hertzberg, R. P., et al. 1989. Modification of the Hydroxy Lactone Ring of Camptothecin: Inhibition of Mammalian topoisomerase I and Biological Activity. J Med Chem, 32: 715-720.
CHARTREUSIN 1 ug/mL Yoshida, T., Habuka, N., Takeuchi, M., Ichishima, E. 1986. Inhibition of DNA Topoisomerase I From Alcaligenes sp. by Chartreusin. Agr Biol Chem, 50: 515-516.
CHEBULAGIC-ACID IC50=50 nM *
CHEBULANIN MIC=0.1 ug/ml Tokura, K., Kagawa, S. 1993. Anticancer Agents Containing Chebulanin From Terminalia chebula. Patent, Japan Kokai Tokkyo Koho-07 138,165. 4pp.
CHELERYTHRINE Fang, S. D., Wang, L. K., Hect, S. M. 1993. Inhibitors of DNA Topoisomerase I Isolated From the Roots of Zanthoxylum nitidum. J Org Chem, 58: 5025-5027.
CHRYSIN Santti, R., Makela, S., Strauss, L., Korman, J., Kostian, M. L. 1998. Phytoestrogens: Potential Endocrine Disruptors in Males. Toxicol Ind Health, 14: 223-237.
CORILAGIN IC50=40 uM Hecht, S. M., Berry, D. E., MacKenzie, L. J., Busby, R. W., Nasuti, C. A. 1992. A Strategy For Identifying Novel, Mechanistically Unique Inhibitors of Topoisomerase I. J Natural Products, 55: 401-413.
CRYPTOLEPINE 5 uM Bonjean, K., et al. 1998. The DNA Intercalating Alkaloid Cryptolepine Interferes with Topoisomerase II and Inhibits Primarily DNA Synthesis in B16 Melanoma Cell. Biochemistry, 37: 5136-5146.
CURCUMIN *
DAIDZEIN Santti, R., Makela, S., Strauss, L., Korman, J., Kostian, M. L. 1998. Phytoestrogens: Potential Endocrine Disruptors in Males. Toxicol Ind Health, 14: 223-237.
DEMETHOXYCURCUMIN *
DIHYDRODAIDZEIN 250 ppm (weak activity) Chang, Y. C., Nair, M. G., Nitiss, L. J. L. 1995. MEtabolites of Daidzein and Genistein and Their Biological Activities. J Natural Products, 58: 1901-1905.
DIHYDROGENISTEIN 250 ppm Chang, Y. C., Nair, M. G., Nitiss, L. J. L. 1995. MEtabolites of Daidzein and Genistein and Their Biological Activities. J Natural Products, 58: 1901-1905.
DIHYDROTANSHINONE-I 1 uM Lee, D. S., Lee, S. H., Kwon, G. S., Lee, H. K., Woo, J. H., Kim, J. G., Hong, S. D. 1999. Inhibition of DNA Topoisomerase I by Dihydrotanshinone I, Components of a Medicinal Herb Salvia miltiorrhiza Bunge. Biosci. Biotech. Biochem., 63: 1370-1373.
DISTAMYCIN Mortensen, U. H., Stevensner, T., Krogh, S., Olesen, K., Westergard, O., Bonven, B. J. 1990. Distamycin Inhibition of Topoisomerase I-DNA Intercation: A Mechanistic Analysis. Nucleic Acids Res, 18: 1983-1989.
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List of Activity Plants.
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Plant Name Common Name Chemical Count Total Parts Per Million
Abelmoschus esculentus Okra 1 0
Abelmoschus moschatus Ambrette; Musk Okra; Tropical Jewel Hibiscus; Muskmallow 2 0
Abrus precatorius Crab's Eye; Jequerity; Coral Beadplant; Indian Licorice; Licorice Vine; Love Bean; Lucky Bean; Minnie-Minnies; Prayer Beads; Precatory Bean; Red Beadvine; Rosary Pea; Weatherplant; Weathervine; Jequirity Bean 1 0
Abutilon theophrasti Velvet Leaf; Butterprint; Indian-Mallow; Abutilon-Hemp 3 0
Acacia catechu Black Cutch; Catechu 4 0
Acacia decurrens Green Wattle 1 0
Acacia farnesiana Cassie; Huisache; Sweet Acacia; Opopanax; Popinac 3 0
Acacia leucophloea Pilang Bast 1 0
Acacia nilotica Babul 2 0
Acacia senegal Gum Arabic; Gum Arabic Tree; Kher; Senegal Gum; Sudan Gum Arabic 2 0
Acacia tortilis Umbrella Thorn 1 0
Acalypha indica Cancer Herb; Indian Acalypha; Copperleaf; Indian Nettle; Three-Seeded-Mercury 1 0
Achillea millefolium Yarrow; Milfoil 4 0
Acinos suaveolens 4 966.4999980926514
Acorus calamus Sweetflag; Calamus; Flagroot; Myrtle Flag; Sweet Calamus; Sweetroot 1 0
Actaea racemosa Black Cohosh; Black Snakeroot 2 0
Actinidia chinensis Kiwi 1 0
Adenocarpus decorticans 1 0
Adenocarpus foliolosus 1 0
Aesculus hippocastanum Horse Chestnut 3 0