Chemical CAMPTOTHECIN

Chemical ID

CAMPTOTHECIN

Ubiquitous

No

List of known dosages
Dosage	Reference
LD50=68.4 mg/kg ipr mus	Huang, K. C. 1993. The Pharmacology of Chinese Herbs. CRC Press, Boca Raton, FL 388 pp.

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List of chemical activities.
Click on column headings to sort table by that column. *Unless otherwise noted all references are to (Duke, 1992)
Activity Sort descending	Dosage	Reference
Anticarcinomic	70 ppb	Duke, 1992 *
Antiherpetic	not available	Duke, 1992 *
Antileukemic	0.5-4 mg/kg	Duke, 1992 *
Antimelanomic	ED50=0.14 ug/ml	J. Ethnopharmacology, 32: 117.
Antipsoriac	not available	Duke, 1992 *
Antisarcomic	ED50=0.0095 ug/ml	J. Ethnopharmacology, 32: 117.
Antitumor (Breast)	ED50=0.043 ug/ml	J. Ethnopharmacology, 32: 117.
Antitumor (Colon)	ED50=0.047 ug/ml	J. Ethnopharmacology, 32: 117.
Antitumor (Lung)	ED50=0.024 ug/ml	J. Ethnopharmacology, 32: 117.
Antiviral	not available	Vlietinck, A.J. and Dommisse, R.A. eds. 1985. Advances in Medicinal Plant Research. Wiss. Verlag. Stuttgart.
Insecticide	not available	Duke, 1992 *
Interferonogenic	not available	Duke, 1992 *
Pesticide	not available	Duke, 1992 *
Topoisomerase-I-Inhibitor	1-50 uM	Duke, 1992 *
Topoisomerase-I-Inhibitor	IC50=670 nM	Luzzio, M. J., et al. 1995. Synthesis and Antitumor Activity of Novel Water Soluble Derivatives of Camptothecin as Specific Inhibitors of Topoisomerase I. J Med Chem, 38: 395-401.
Topoisomerase-I-Inhibitor	IC50=1 uM	Weller, M., et al. 1997. Topoisomerase I Inhibitors For Human Malignant Glioma: Differential Modulation of P53, P21, BAX and BEL-2 Expression and of CD95-Mediated Apoptosis. Int J Cancer, 73: 707-714.
Topoisomerase-I-Inhibitor	ED50=0.8 uM	Hertzberg, R. P., et al. 1989. Modification of the Hydroxy Lactone Ring of Camptothecin: Inhibition of Mammalian topoisomerase I and Biological Activity. J Med Chem, 32: 715-720.
Topoisomerase-I-Poison	not available	Journal of Medicinal Food 2: 167.1999.
Topoisomerase-II-Inhibitor	not available	Rose, K. M. 1988. DNA Topoisomerases as Targets for Chemotherapy. Faseb J, 2: 2474-2478.

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List of chemical plants.
Click on column headings to sort table by that column. *Unless otherwise noted all references are to (Duke, 1992)
Plant Name Sort descending	Plant Part	Low Parts Per Million	High Parts Per Million	Standard Deviation	Reference
Camptotheca acuminata	Seed	not available	300.0	not available	Duke, 1992 *
Camptotheca acuminata	Stem	not available	100.0	not available	Duke, 1992 *