Chemical CAMPTOTHECIN

List of chemical activities.
Click on column headings to sort table by that column. *Unless otherwise noted all references are to (Duke, 1992)

Activity Sort descending	Dosage	Reference
Anticarcinomic	70 ppb	Duke, 1992 *
Antiherpetic	not available	Duke, 1992 *
Antileukemic	0.5-4 mg/kg	Duke, 1992 *
Antimelanomic	ED50=0.14 ug/ml	J. Ethnopharmacology, 32: 117.
Antipsoriac	not available	Duke, 1992 *
Antisarcomic	ED50=0.0095 ug/ml	J. Ethnopharmacology, 32: 117.
Antitumor (Breast)	ED50=0.043 ug/ml	J. Ethnopharmacology, 32: 117.
Antitumor (Colon)	ED50=0.047 ug/ml	J. Ethnopharmacology, 32: 117.
Antitumor (Lung)	ED50=0.024 ug/ml	J. Ethnopharmacology, 32: 117.
Antiviral	not available	Vlietinck, A.J. and Dommisse, R.A. eds. 1985. Advances in Medicinal Plant Research. Wiss. Verlag. Stuttgart.
Insecticide	not available	Duke, 1992 *
Interferonogenic	not available	Duke, 1992 *
Pesticide	not available	Duke, 1992 *
Topoisomerase-I-Inhibitor	1-50 uM	Duke, 1992 *
Topoisomerase-I-Inhibitor	IC50=670 nM	Luzzio, M. J., et al. 1995. Synthesis and Antitumor Activity of Novel Water Soluble Derivatives of Camptothecin as Specific Inhibitors of Topoisomerase I. J Med Chem, 38: 395-401.
Topoisomerase-I-Inhibitor	IC50=1 uM	Weller, M., et al. 1997. Topoisomerase I Inhibitors For Human Malignant Glioma: Differential Modulation of P53, P21, BAX and BEL-2 Expression and of CD95-Mediated Apoptosis. Int J Cancer, 73: 707-714.
Topoisomerase-I-Inhibitor	ED50=0.8 uM	Hertzberg, R. P., et al. 1989. Modification of the Hydroxy Lactone Ring of Camptothecin: Inhibition of Mammalian topoisomerase I and Biological Activity. J Med Chem, 32: 715-720.
Topoisomerase-I-Poison	not available	Journal of Medicinal Food 2: 167.1999.
Topoisomerase-II-Inhibitor	not available	Rose, K. M. 1988. DNA Topoisomerases as Targets for Chemotherapy. Faseb J, 2: 2474-2478.