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Dr. Duke's Phytochemical and Ethnobotanical Databases
U.S. Department of Agriculture
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Quinone-Reductase-Inducer

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List of activity chemicals.
Click on column headings to sort table by that column. *Unless otherwise noted all references are to (Duke, 1992)
Chemical Name Dosage Reference
BRASSININ 0.22 uM Mehta, R. G., Liu, J. F., Constantinou, A., Thomas, C. E., Hawthorne, M., You, M., Gerhauser, C., Pezzuto, J. M., Moon, R. C., Moriarty, R. M. 1995. Cancer Chemopreventive Activity of Brassinin, a Phytoalexin from Cabbage. Carcinogenesis, 16(2): 399-404.
CARNOSOL 100 mg/kg ipr rat Singletary, K. W. 1996. Rosemary Extract and Carnosol Stimulate Rat Liver Glutathione-s-transferase and Quinone Reductase Activities. Cancer Lett., 100: 139-144.
CATECHOL Madhavi, D. L., Bomser, J., Smith, M., Singletary, K. 1998. Isolation of Bioactive Constituents from Vaccinium myrtillus (Bilberry) Fruits and Cell Cultures. Plant Sci., 131(1): 95-103.
CHEIROLIN 1.3 uM Zhang, Y., Talalay, P., Cho, C. G., Posner, G. H. 1992. A Major Inducer of Anticarcinogenic Protective Enzymes from Broccoli: Isolation and Elucidation of Structure. Proc. Nat. Acad. Sci., 89: 2399-2403.
CURCUMIN 3.4 uM Singletary, K., et al. 1998. Effect of the Beta-Diketones Diferoloylmethane (Curcumin) and Dibenzoylmethane on Rat Mammary DNA Adducts and Tumors Induced by 7,12-dimethylbenz(A)anthracene. Carcinogenesis, 19(6): 1039-1043.
CYCLOBRASSININ .22 uM Mehta, R. G., Liu, J. F., Constantinou, A., Thomas, C. E., Hawthorne, M., You, M., Gerhauser, C., Pezzuto, J. M., Moon, R. C., Moriarty, R. M. 1995. Cancer Chemopreventive Activity of Brassinin, a Phytoalexin from Cabbage. Carcinogenesis, 16(2): 399-404.
DAIDZEIN Yannai, S., Day, A. J., Williamson, G., Rhodes, M. J. C. 1998. Characterization of Flavonoids as Monofunctional or Bifunctional Inducers of Quinone Reductase in Murine Hepatoma Cell Lines. Food Chem Toxicol, 36(8): 623-630.
DEMETHOXYCURCUMIN 12.5 uM Singletary, K., et al. 1998. Effect of the Beta-Diketones Diferoloylmethane (Curcumin) and Dibenzoylmethane on Rat Mammary DNA Adducts and Tumors Induced by 7,12-dimethylbenz(A)anthracene. Carcinogenesis, 19(6): 1039-1043.
DEMETHOXYCURCUMIN 1% diet rat Singletary, K., et al. 1998. Effect of the Beta-Diketones Diferoloylmethane (Curcumin) and Dibenzoylmethane on Rat Mammary DNA Adducts and Tumors Induced by 7,12-dimethylbenz(A)anthracene. Carcinogenesis, 19(6): 1039-1043.
DIALLYL-DISULFIDE 0.3 mg/kg *
ELLAGIC-ACID 0.4 g/kg rat Ahn, D., Putt, D., Kresty, L., Stoner, G. D., Fromm, D., Hollenberg, P. F. 1996. The Effects of Dietary Ellagic Acid on Rat Hepatic and Esophageal Mucosal Cytochromes P450 and Phase II Enzymes. Carcinogenesis, 17(4): 821-828.
ERUCIN 15 uM/day igs mus Zhang, Y., Talalay, P., Cho, C. G., Posner, G. H. 1992. A Major Inducer of Anticarcinogenic Protective Enzymes from Broccoli: Isolation and Elucidation of Structure. Proc. Nat. Acad. Sci., 89: 2399-2403.
ERYSOLIN 5.0 uM Zhang, Y., Talalay, P., Cho, C. G., Posner, G. H. 1992. A Major Inducer of Anticarcinogenic Protective Enzymes from Broccoli: Isolation and Elucidation of Structure. Proc. Nat. Acad. Sci., 89: 2399-2403.
GALANGAL-ACETATE 50 mg/kg igs rat Tanaka, T., et al. 1997. Chemoprevention of Azoxymethane-Induced Rat Colon Carcinogenesis by a Xanthine Oxidase Inhibitor, 1'-acetoxychavicol acetate. Jap. J. Cancer Res., 88(9): 821-830.
GALANGIN 4 uM Uda, Y., Price, K. R., Williamson, G., Rhodes, M. J. C. 1997. Induction of the Anticarcinogenic Marker Enzyme, Quinone Reductase, in Murine Hepatoma Cells In Vitro by Flavonoids. Cancer Lett., 120 (2): 213-216.
GENISTEIN IC50=4.6 ug/ml *
GLUCOBRASSICANAPIN 15 uM Tawfig,N. Heaney,R.K.,Plumb,J.A.,Fenwick,G.R.,Musk,S.R.R.,Williamson,G.1995. Dietary Glucosinolates as Blocking Agents Against Carcinogenesis: Glucosinolate Breakdown Products Assessed Induction of Quinone Reductase Activity I.Carcinogenesis 16(5)119-1194
GLUCOBRASSICIN 100 uM Fahey, J. W., Zhang, Y., Talalay, P. 1997. Broccoli Sprouts: An Exceptionally Rich Source of Inducers of Enzymes that Protects Against Chemical Carcinogens. Proc. Nat. Acad. Sci., 94: 10367-10372.
GLUCOIBERIN 15 uM Tawfig,N. Heaney,R.K.,Plumb,J.A.,Fenwick,G.R.,Musk,S.R.R.,Williamson,G.1995. Dietary Glucosinolates as Blocking Agents Against Carcinogenesis: Glucosinolate Breakdown Products Assessed Induction of Quinone Reductase Activity I.Carcinogenesis 16(5)119-1194
GLUCONAPIN Tawfig,N. Heaney,R.K.,Plumb,J.A.,Fenwick,G.R.,Musk,S.R.R.,Williamson,G.1995. Dietary Glucosinolates as Blocking Agents Against Carcinogenesis: Glucosinolate Breakdown Products Assessed Induction of Quinone Reductase Activity I.Carcinogenesis 16(5)119-1194
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List of Activity Plants.
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Plant Name Common Name Chemical Count Total Parts Per Million
Citrullus lanatus Watermelon 1 3
Citrus aurantium Petitgrain; Bitter Orange 1 0
Citrus limon Lemon 4 1.2000000476837158
Citrus paradisi Grapefruit 5 0.949999988079071
Citrus reticulata Mandarin; Tangerine 2 4
Citrus sinensis Orange 5 12.300000190734863
Citrus spp Citrus 2 0
Clitoria falcata 1 0
Clitoria ternatea 1 25
Cnicus benedictus Blessed Thistle 1 0
Cola acuminata Abata Cola 1 0
Colchicum autumnale Autumn Crocus; Meadow Saffron 1 0
Cologana broussonetii 1 0
Commiphora wightii Guggul; Indian Bdellium-Tree 2 0
Consolida ajacis Larkspur 2 0
Convallaria majalis Lily-Of-The-Valley 1 0
Conyza canadensis Butterweed; Hogweed; Horseweed 1 0
Coriandrum sativum Coriander; Chinese Parsley; Cilantro 3 0
Coriaria myrtifolia Mealy Tree 2 0
Coriaria thymifolia Ground Toot; Shanshi 2 0