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Dr. Duke's Phytochemical and Ethnobotanical Databases
U.S. Department of Agriculture
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Quinone-Reductase-Inducer

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List of activity chemicals.
Click on column headings to sort table by that column. *Unless otherwise noted all references are to (Duke, 1992)
Chemical Name Dosage Reference
(+)-PURPURIN ED50=5.6 uM *
(+)-TEPHROPURPURIN IC50 13.4 uM *
(+)-TEPHROPURPURIN ED50=0.15 uM *
(-)-3-HYDROXY-4-METHOXY-8,9-METHYLENEDIOXYPTEROCARPAN IC50=>63.7 uM *
(-)-MAACKIAIN ED50=8.8 uM *
(-)-MEDICARPIN ED50=13.7 uM *
(1'S)-1'-ACETOXYCHAVICOL-ACETATE *
24,25-DIHYDROWITHANOLIDE-D ED50=0.7 uM Kennelly, E. J., Gerhauser, C., Song, L. L., Graham, J. G., Beecher, C. W. W., Pezzuto, J. M., Kinghorn, A. D. 1997. Induction of Quinone Reductase by Withanolides Isolated from Physalis philadelphica (Tomatillos). J. Agr. & Food Chem., 45(10): 3771-3777.
3-METHOXY-2,3-DIHYDROWITHAPHYSACARPIN ED50=7.8 uM Kennelly, E. J., Gerhauser, C., Song, L. L., Graham, J. G., Beecher, C. W. W., Pezzuto, J. M., Kinghorn, A. D. 1997. Induction of Quinone Reductase by Withanolides Isolated from Physalis philadelphica (Tomatillos). J. Agr. & Food Chem., 45(10): 3771-3777.
4',7-DIHYDROXY-3',5'-DIMETHOXYISOFLAVONE ED50=17.2 uM *
4-HYDROXY-GLUCOBRASSICIN 100 uM Fahey, J. W., Zhang, Y., Talalay, P. 1997. Broccoli Sprouts: An Exceptionally Rich Source of Inducers of Enzymes that Protects Against Chemical Carcinogens. Proc. Nat. Acad. Sci., 94: 10367-10372.
6-METHYL-SULFINYL-HEXYL-ISOTHIOCYANATE Fuke, Y., Haga, Y., Ono, H., Nomura, T., Ryoyama, K. 1998. Anti-Carcinogenic Activity of 6-methylsulfinylhexyl isothiocyanate, an Active Anti-Proliferative Principle of Wasabi (Eutrema wasabi Maxim.). Cytotechnology, 25: 197-203.
7,4'-DIHYDROXY-3',5'-DIMETHOXYISOFLAVONE IC50>63.7 uM *
ALYSSIN 0.95 uM *
APIGENIN 20 uM Uda, Y., Price, K. R., Williamson, G., Rhodes, M. J. C. 1997. Induction of the Anticarcinogenic Marker Enzyme, Quinone Reductase, in Murine Hepatoma Cells In Vitro by Flavonoids. Cancer Lett., 120 (2): 213-216.
AURAPTENE 100 ppm *
AURAPTENE 400 mg/kg igs rat Tanaka,T. et al.1998.Citrus Auraptene Exerts Dose-Dependent Chemopreventive Activity in Rat Large Bowel Tumorigenesis:The Inhibition Correlates with Suppression of Cell Proliferation & Lipid Peroxidation & with Induction of Phase II-. Cancer Res.58:2550.
BAICALIN *
BERTEROIN 1.7 uM Zhang, Y., Talalay, P., Cho, C. G., Posner, G. H. 1992. A Major Inducer of Anticarcinogenic Protective Enzymes from Broccoli: Isolation and Elucidation of Structure. Proc. Nat. Acad. Sci., 89: 2399-2403.
BIS-DEMETHOXYCURCUMIN 11.9 uM Singletary, K., et al. 1998. Effect of the Beta-Diketones Diferoloylmethane (Curcumin) and Dibenzoylmethane on Rat Mammary DNA Adducts and Tumors Induced by 7,12-dimethylbenz(A)anthracene. Carcinogenesis, 19(6): 1039-1043.
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List of Activity Plants.
Click on column headings to sort table by that column.
Plant Name Common Name Chemical Count Total Parts Per Million
Brassica oleracea var. botrytis l. Cauliflower 12 16, 715
Brassica oleracea var. capitata l. Cabbage; Red Cabbage; White Cabbage 16 1, 663.8000025078654
Brassica oleracea var. gemmifera Brussels-Sprouts; Brussel-Sprout 7 100
Brassica oleracea var. italica Broccoli; Heading Broccoli; Sprouting Broccoli; Cape Broccoli; Purple Cauliflower; Asparagus Broccoli; Winter Broccoli; Calabrese 13 82, 304
Brassica oleracea var. sabellica l. Kale; Curly Kale; Kitchen Kale; Scotch Kale 7 452
Brassica oleracea var. viridis l. Collards; Cow Cabbage; Tall Kale; Tree Kale; Spring-Heading Cabbage 4 0
Brassica rapa Pak-Choi; Chinese Mustard; Bok-Choy; Celery Mustard; Chinese White Cabbage; Celery Cabbage; Chinese Cabbage 1 0
Caesalpinia pulcherrima Bird Of Paradise 3 0
Cajanus cajan Pigeonpea 1 0
Cajanus scarabaeoides 1 3
Calendula officinalis Calendula; Pot-Marigold 3 0
Calicotome spinosa 1 0
Calicotome villosa 1 0
Calopogonium caeruleum 1 0
Camellia sinensis Tea 6 20, 860
Camptosema sp 1 12
Camptotheca acuminata Happy Tree 1 0
Canavalia ensiformis Jack Bean 1 6
Canavalia eurycarpa 1 5
Canavalia galeata 1 0