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Dr. Duke's Phytochemical and Ethnobotanical Databases
U.S. Department of Agriculture
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Quinone-Reductase-Inducer

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List of activity chemicals.
Click on column headings to sort table by that column. *Unless otherwise noted all references are to (Duke, 1992)
Chemical Name Dosage Reference
(+)-PURPURIN ED50=5.6 uM *
(+)-TEPHROPURPURIN ED50=0.15 uM *
(+)-TEPHROPURPURIN IC50 13.4 uM *
(-)-3-HYDROXY-4-METHOXY-8,9-METHYLENEDIOXYPTEROCARPAN IC50=>63.7 uM *
(-)-MAACKIAIN ED50=8.8 uM *
(-)-MEDICARPIN ED50=13.7 uM *
(1'S)-1'-ACETOXYCHAVICOL-ACETATE *
24,25-DIHYDROWITHANOLIDE-D ED50=0.7 uM Kennelly, E. J., Gerhauser, C., Song, L. L., Graham, J. G., Beecher, C. W. W., Pezzuto, J. M., Kinghorn, A. D. 1997. Induction of Quinone Reductase by Withanolides Isolated from Physalis philadelphica (Tomatillos). J. Agr. & Food Chem., 45(10): 3771-3777.
3-METHOXY-2,3-DIHYDROWITHAPHYSACARPIN ED50=7.8 uM Kennelly, E. J., Gerhauser, C., Song, L. L., Graham, J. G., Beecher, C. W. W., Pezzuto, J. M., Kinghorn, A. D. 1997. Induction of Quinone Reductase by Withanolides Isolated from Physalis philadelphica (Tomatillos). J. Agr. & Food Chem., 45(10): 3771-3777.
4',7-DIHYDROXY-3',5'-DIMETHOXYISOFLAVONE ED50=17.2 uM *
4-HYDROXY-GLUCOBRASSICIN 100 uM Fahey, J. W., Zhang, Y., Talalay, P. 1997. Broccoli Sprouts: An Exceptionally Rich Source of Inducers of Enzymes that Protects Against Chemical Carcinogens. Proc. Nat. Acad. Sci., 94: 10367-10372.
6-METHYL-SULFINYL-HEXYL-ISOTHIOCYANATE Fuke, Y., Haga, Y., Ono, H., Nomura, T., Ryoyama, K. 1998. Anti-Carcinogenic Activity of 6-methylsulfinylhexyl isothiocyanate, an Active Anti-Proliferative Principle of Wasabi (Eutrema wasabi Maxim.). Cytotechnology, 25: 197-203.
7,4'-DIHYDROXY-3',5'-DIMETHOXYISOFLAVONE IC50>63.7 uM *
ALYSSIN 0.95 uM *
APIGENIN 20 uM Uda, Y., Price, K. R., Williamson, G., Rhodes, M. J. C. 1997. Induction of the Anticarcinogenic Marker Enzyme, Quinone Reductase, in Murine Hepatoma Cells In Vitro by Flavonoids. Cancer Lett., 120 (2): 213-216.
AURAPTENE 100 ppm *
AURAPTENE 400 mg/kg igs rat Tanaka,T. et al.1998.Citrus Auraptene Exerts Dose-Dependent Chemopreventive Activity in Rat Large Bowel Tumorigenesis:The Inhibition Correlates with Suppression of Cell Proliferation & Lipid Peroxidation & with Induction of Phase II-. Cancer Res.58:2550.
BAICALIN *
BERTEROIN 1.7 uM Zhang, Y., Talalay, P., Cho, C. G., Posner, G. H. 1992. A Major Inducer of Anticarcinogenic Protective Enzymes from Broccoli: Isolation and Elucidation of Structure. Proc. Nat. Acad. Sci., 89: 2399-2403.
BIS-DEMETHOXYCURCUMIN 11.9 uM Singletary, K., et al. 1998. Effect of the Beta-Diketones Diferoloylmethane (Curcumin) and Dibenzoylmethane on Rat Mammary DNA Adducts and Tumors Induced by 7,12-dimethylbenz(A)anthracene. Carcinogenesis, 19(6): 1039-1043.
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List of Activity Plants.
Click on column headings to sort table by that column.
Plant Name Common Name Chemical Count Total Parts Per Million
Canavalia gladiata 1 0
Canavalia rosea 1 0
Canavalia sericea 1 0
Canavalia virosa 1 0
Capparis spinosa Caper; Caperbush 3 0
Capsella bursa-pastoris Shepherd's Purse 2 0
Capsicum annuum Bell Pepper; Green Pepper; Cherry Pepper; Sweet Pepper; Cone Pepper; Paprika 3 9, 456
Capsicum frutescens Cayenne; Chili; Tabasco; Hot Pepper; Spur Pepper; Red Chili 4 756
Carica papaya Papaya 1 0
Carum carvi Caraway; Carum; Kummel (Ger.); Comino (Sp.); Comino de prado (Sp.) 2 0
Castanea sativa European Chestnut 3 0
Catalpa bignonioides Indian bean 1 0
Catharanthus roseus Madagascar Periwinkle; Rosy Periwinkle 3 0
Cedrus deodora Deodar Cedar 1 0
Ceiba pentandra Kapok; Silk-Cotton Tree 2 0
Centaurea calcitrapa Star-Thistle 2 0
Centaurea cyanus Cornflower; Bachelor's Button 4 0
Centella asiatica Gotu Kola; Pennywort 2 0
Centrosema pascuorum 1 0
Centrosema plumieri 1 0