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Dr. Duke's Phytochemical and Ethnobotanical Databases
U.S. Department of Agriculture

Biological Activity Quinone-Reductase-Inducer

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List of activity chemicals.
Click on column headings to sort table by that column. *Unless otherwise noted all references are to (Duke, 1992)
Chemical Name Dosage Reference
(+)-PURPURIN ED50=5.6 uM *
(+)-TEPHROPURPURIN IC50 13.4 uM *
(+)-TEPHROPURPURIN ED50=0.15 uM *
(-)-3-HYDROXY-4-METHOXY-8,9-METHYLENEDIOXYPTEROCARPAN IC50=>63.7 uM *
(-)-MAACKIAIN ED50=8.8 uM *
(-)-MEDICARPIN ED50=13.7 uM *
(1'S)-1'-ACETOXYCHAVICOL-ACETATE *
24,25-DIHYDROWITHANOLIDE-D ED50=0.7 uM Kennelly, E. J., Gerhauser, C., Song, L. L., Graham, J. G., Beecher, C. W. W., Pezzuto, J. M., Kinghorn, A. D. 1997. Induction of Quinone Reductase by Withanolides Isolated from Physalis philadelphica (Tomatillos). J. Agr. & Food Chem., 45(10): 3771-3777.
3-METHOXY-2,3-DIHYDROWITHAPHYSACARPIN ED50=7.8 uM Kennelly, E. J., Gerhauser, C., Song, L. L., Graham, J. G., Beecher, C. W. W., Pezzuto, J. M., Kinghorn, A. D. 1997. Induction of Quinone Reductase by Withanolides Isolated from Physalis philadelphica (Tomatillos). J. Agr. & Food Chem., 45(10): 3771-3777.
4',7-DIHYDROXY-3',5'-DIMETHOXYISOFLAVONE ED50=17.2 uM *
4-HYDROXY-GLUCOBRASSICIN 100 uM Fahey, J. W., Zhang, Y., Talalay, P. 1997. Broccoli Sprouts: An Exceptionally Rich Source of Inducers of Enzymes that Protects Against Chemical Carcinogens. Proc. Nat. Acad. Sci., 94: 10367-10372.
6-METHYL-SULFINYL-HEXYL-ISOTHIOCYANATE Fuke, Y., Haga, Y., Ono, H., Nomura, T., Ryoyama, K. 1998. Anti-Carcinogenic Activity of 6-methylsulfinylhexyl isothiocyanate, an Active Anti-Proliferative Principle of Wasabi (Eutrema wasabi Maxim.). Cytotechnology, 25: 197-203.
7,4'-DIHYDROXY-3',5'-DIMETHOXYISOFLAVONE IC50>63.7 uM *
ALYSSIN 0.95 uM *
APIGENIN 20 uM Uda, Y., Price, K. R., Williamson, G., Rhodes, M. J. C. 1997. Induction of the Anticarcinogenic Marker Enzyme, Quinone Reductase, in Murine Hepatoma Cells In Vitro by Flavonoids. Cancer Lett., 120 (2): 213-216.
AURAPTENE 100 ppm *
AURAPTENE 400 mg/kg igs rat Tanaka,T. et al.1998.Citrus Auraptene Exerts Dose-Dependent Chemopreventive Activity in Rat Large Bowel Tumorigenesis:The Inhibition Correlates with Suppression of Cell Proliferation & Lipid Peroxidation & with Induction of Phase II-. Cancer Res.58:2550.
BAICALIN *
BERTEROIN 1.7 uM Zhang, Y., Talalay, P., Cho, C. G., Posner, G. H. 1992. A Major Inducer of Anticarcinogenic Protective Enzymes from Broccoli: Isolation and Elucidation of Structure. Proc. Nat. Acad. Sci., 89: 2399-2403.
BIS-DEMETHOXYCURCUMIN 11.9 uM Singletary, K., et al. 1998. Effect of the Beta-Diketones Diferoloylmethane (Curcumin) and Dibenzoylmethane on Rat Mammary DNA Adducts and Tumors Induced by 7,12-dimethylbenz(A)anthracene. Carcinogenesis, 19(6): 1039-1043.
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List of Activity Plants.
Click on column headings to sort table by that column.
Plant Name Common Name Chemical Count Total Parts Per Million
Anethum graveolens Dill; Garden Dill 4 0
Angelica archangelica Garden Angelica; Angelica; Wild Parsnip 2 0
Anisochilus carnosus Panjiri-ka Pat 1 0
Anogeissus latifolia Gum Ghatti 3 0
Apios americana 1 12
Apium graveolens Celery 3 1, 910
Arachis hypogaea Groundnut; Peanut 1 0
Araucaria bidwillii Monkey puzzle 3 0
Arbutus unedo Arbutus; Strawberry Tree 3 0
Arctostaphylos uva-ursi Bearberry; Uva Ursi 4 15, 000
Ardisia japonica Marlberry 1 0
Argyrocytisus battandieri 1 0
Armoracia rusticana Horseradish 6 3, 006
Arnica montana Leopard's-Bane; Mountain Tobacco 2 0
Artemisia annua Qinghao; Sweet Annie; Annual Mugwort (GRIN); Annual Wormwood (GRIN); Sweet Wormwood (GRIN) 5 0
Artemisia dracunculus Tarragon 4 7
Artocarpus altilis Breadfruit 1 0
Artocarpus heterophyllus Jackfruit 1 0
Asimina triloba Pawpaw 1 0
Aspalathus linearis Rooibos; Kaffree Tea; Red Bush Tea 1 52.799999713897705