Biological Activity Quinone-Reductase-Inducer | Dr. Duke's Phytochemical and Ethnobotanical Databases

Download these results as:

List of activity chemicals.
Click on column headings to sort table by that column. *Unless otherwise noted all references are to (Duke, 1992)
Chemical Name	Dosage	Reference
(+)-PURPURIN	ED50=5.6 uM	Duke, 1992 *
(+)-TEPHROPURPURIN	IC50 13.4 uM	Duke, 1992 *
(+)-TEPHROPURPURIN	ED50=0.15 uM	Duke, 1992 *
(-)-3-HYDROXY-4-METHOXY-8,9-METHYLENEDIOXYPTEROCARPAN	IC50=>63.7 uM	Duke, 1992 *
(-)-MAACKIAIN	ED50=8.8 uM	Duke, 1992 *
(-)-MEDICARPIN	ED50=13.7 uM	Duke, 1992 *
(1'S)-1'-ACETOXYCHAVICOL-ACETATE	not available	Duke, 1992 *
24,25-DIHYDROWITHANOLIDE-D	ED50=0.7 uM	Kennelly, E. J., Gerhauser, C., Song, L. L., Graham, J. G., Beecher, C. W. W., Pezzuto, J. M., Kinghorn, A. D. 1997. Induction of Quinone Reductase by Withanolides Isolated from Physalis philadelphica (Tomatillos). J. Agr. & Food Chem., 45(10): 3771-3777.
3-METHOXY-2,3-DIHYDROWITHAPHYSACARPIN	ED50=7.8 uM	Kennelly, E. J., Gerhauser, C., Song, L. L., Graham, J. G., Beecher, C. W. W., Pezzuto, J. M., Kinghorn, A. D. 1997. Induction of Quinone Reductase by Withanolides Isolated from Physalis philadelphica (Tomatillos). J. Agr. & Food Chem., 45(10): 3771-3777.
4',7-DIHYDROXY-3',5'-DIMETHOXYISOFLAVONE	ED50=17.2 uM	Duke, 1992 *
4-HYDROXY-GLUCOBRASSICIN	100 uM	Fahey, J. W., Zhang, Y., Talalay, P. 1997. Broccoli Sprouts: An Exceptionally Rich Source of Inducers of Enzymes that Protects Against Chemical Carcinogens. Proc. Nat. Acad. Sci., 94: 10367-10372.
6-METHYL-SULFINYL-HEXYL-ISOTHIOCYANATE	not available	Fuke, Y., Haga, Y., Ono, H., Nomura, T., Ryoyama, K. 1998. Anti-Carcinogenic Activity of 6-methylsulfinylhexyl isothiocyanate, an Active Anti-Proliferative Principle of Wasabi (Eutrema wasabi Maxim.). Cytotechnology, 25: 197-203.
7,4'-DIHYDROXY-3',5'-DIMETHOXYISOFLAVONE	IC50>63.7 uM	Duke, 1992 *
ALYSSIN	0.95 uM	Duke, 1992 *
APIGENIN	20 uM	Uda, Y., Price, K. R., Williamson, G., Rhodes, M. J. C. 1997. Induction of the Anticarcinogenic Marker Enzyme, Quinone Reductase, in Murine Hepatoma Cells In Vitro by Flavonoids. Cancer Lett., 120 (2): 213-216.
AURAPTENE	100 ppm	Duke, 1992 *
AURAPTENE	400 mg/kg igs rat	Tanaka,T. et al.1998.Citrus Auraptene Exerts Dose-Dependent Chemopreventive Activity in Rat Large Bowel Tumorigenesis:The Inhibition Correlates with Suppression of Cell Proliferation & Lipid Peroxidation & with Induction of Phase II-. Cancer Res.58:2550.
BAICALIN	not available	Duke, 1992 *
BERTEROIN	1.7 uM	Zhang, Y., Talalay, P., Cho, C. G., Posner, G. H. 1992. A Major Inducer of Anticarcinogenic Protective Enzymes from Broccoli: Isolation and Elucidation of Structure. Proc. Nat. Acad. Sci., 89: 2399-2403.
BIS-DEMETHOXYCURCUMIN	11.9 uM	Singletary, K., et al. 1998. Effect of the Beta-Diketones Diferoloylmethane (Curcumin) and Dibenzoylmethane on Rat Mammary DNA Adducts and Tumors Induced by 7,12-dimethylbenz(A)anthracene. Carcinogenesis, 19(6): 1039-1043.

Download these results as:

CSV

EXCEL

PDF

List of Activity Plants.
Click on column headings to sort table by that column.
Plant Name	Common Name	Chemical Count	Total Parts Per Million
Cornus florida	American Dogwood	3	0
Cornus mas	Cornelian Cherry; Sorbet	4	0
Cornus officinalis	Chinese Dogwood	1	0
Corylus avellana	English Filbert; European Filbert; European Hazel; Hazel; Cobnut	3	0
Costus speciosus	Crepe Ginger; Wild Ginger; Cane Reed	1	0
Crataegus cuneata	Hawthorn	2	0
Crataegus laevigata	Hawthorn; English Hawthorn; Whitethorn; Woodland Hawthorn	4	0
Crataegus monogyna	Hawthorn; English Hawthorn	5	80
Crataegus rhipidophylla	Hawthorn	3	0
Crocus sativus	Saffron	4	0
Crotalaria juncea	Sunhemp	1	0
Cryptostegia grandifolia	Rubber Vine	1	0
Cucurbita pepo	Pumpkin	4	0
Curcuma longa	Turmeric; Indian Saffron	4	543, 580
Curcuma xanthorrhiza	Javan Turmeric; Temu Lawak	1	20, 000
Curcuma zedoaria	Shoti; Zedoary	1	2, 000
Cuscuta reflexa	Amarbel	1	0
Cyamopsis tetragonoloba	Guar; Cluster-Bean; Siam-Bean	3	0
Cycas revoluta	Sago Cycas	1	0
Cymbopogon citratus	West Indian Lemongrass; Lemongrass	1	0