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Dr. Duke's Phytochemical and Ethnobotanical Databases
U.S. Department of Agriculture
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MDR-Inhibitor

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List of activity chemicals.
Click on column headings to sort table by that column. *Unless otherwise noted all references are to (Duke, 1992)
Chemical Name Dosage Reference
TOLYPORPHIN-C 0.5 ug/ml Prinsep, M. R., Patterson, G. M. L., Larsen, L. K., Smith, C. D. 1995. Further Tolyporphins From the Blu-Green Alga Tolypothrix nodosa. Tetrahedron, 51(38): 10523-10530.
TOLYPORPHIN-D 0.5 ug/ml Prinsep, M. R., Patterson, G. M. L., Larsen, L. K., Smith, C. D. 1995. Further Tolyporphins From the Blu-Green Alga Tolypothrix nodosa. Tetrahedron, 51(38): 10523-10530.
TOLYPORPHIN-F 0.5 ug/ml Prinsep, M. R., Patterson, G. M. L., Larsen, L. K., Smith, C. D. 1995. Further Tolyporphins From the Blu-Green Alga Tolypothrix nodosa. Tetrahedron, 51(38): 10523-10530.
TOLYPORPHIN-G 0.5 ug/ml Prinsep, M. R., Patterson, G. M. L., Larsen, L. K., Smith, C. D. 1995. Further Tolyporphins From the Blu-Green Alga Tolypothrix nodosa. Tetrahedron, 51(38): 10523-10530.
TOLYPORPHIN-H 0.5 ug/ml Prinsep, M. R., Patterson, G. M. L., Larsen, L. K., Smith, C. D. 1995. Further Tolyporphins From the Blu-Green Alga Tolypothrix nodosa. Tetrahedron, 51(38): 10523-10530.
TOLYPORPHIN-J 2.5 ug/ml Prinsep, M. R., Patterson, G. M. L., Larsen, L. K., Smith, C. D. 1998. Tolyporphins J and K, Two Further Porphinoid Metabolites From the Cyanobacterium Tolypothrix nodosa. J. Nat. Prod., 61(9): 1133-1136.
TOLYPORPHIN-K 2.5-10 ug/ml Prinsep, M. R., Patterson, G. M. L., Larsen, L. K., Smith, C. D. 1998. Tolyporphins J and K, Two Further Porphinoid Metabolites From the Cyanobacterium Tolypothrix nodosa. J. Nat. Prod., 61(9): 1133-1136.
TORILIN 10-30 uM *
TRIACETYLTAXICIN-I 1 ug/mL Kobayashi, J., et al. 1997. Effects of Taxoids From Taxus cuspidata on Microtubule Depolymerization and Vincristine Accumulation in MDR Cells. Bioorg. Med. Chem. Lett., 7: 393-398.
VINCALEUKOBLASTINE 100 uM Critchfield, J. W., Welsh, C. J., Phang, J. M., Yeh, G. C. 1994. Modulation of Adriamycin Accumulation and Efflux by Flavonoids in HCT-15 Colon Cells. Activation of P-Glycoprotein as a Putative Mechanism. Biochem Pharmacol, 48(7): 1437-1445.
VOACAMINE IC50=2 ug/ml You, M., et al. 1994. Indole Alkaloids From Peschiera laeta That Enhance Vinblastine-Mediated Cytotoxicity With Multidrug-Resistant Cells. J. Nat. Prod., 57(11): 1517-1522.
YOHIMBINE 10 uM Bhat, U. G., et al. 1995. A Structure-Function Relationship Among Reserpine and Yohimbine Analogues in Their Ability to Increase Expression of MDR1 and P-Glycoprotein in a Human Colon Carcinoma Cell Line. Mol Pharmacol, 48(4): 682-689.
ZINGIBEROSIDE-R1 25 uM Hasegawa,H.,Sung,J.H.,Matsumiya,S.,Uchiyama,M.,Inouye,Y.,Kasai,R.,Yamasaki,K. 1995. Reversal of Daunomycin and Vinblastine Resistance in Multidrug-Resistance P388 Leukemia in vitro through Enhanced Cytotoxicity by Triterpenoids. Planta Med, 61(5):409-413.
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List of Activity Plants.
Click on column headings to sort table by that column.
Plant Name Common Name Chemical Count Total Parts Per Million
Hedeoma pulegioides American Pennyroyal 1 10, 000
Hyssopus officinalis Hyssop 1 60, 000
Kennedia coccinea 1 49
Kennedia nigricans 1 24
Kennedia procurrens 1 33
Kennedia rubicunda 1 25
Laburnum alpinum 1 0
Laburnum anagyroides Golden Chain Tree 1 0
Lembotropis emerifolia 1 0
Lens culinaris Lentil 1 25
Lespedeza cyrtobotrya 1 0
Lupinus albus White Lupine 1 0
Lupinus luteus 1 0
Lupinus perennis 1 0
Lygos monosperma 1 0
Lygos raetum 1 0
Maackia amurensis 1 0
Macroptylium atropurpureum 1 0
Macroptylium bracteatum 1 5
Macroptylium lathyroides 1 0