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Dr. Duke's Phytochemical and Ethnobotanical Databases
U.S. Department of Agriculture
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Topoisomerase-II-Inhibitor

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List of activity chemicals.
Click on column headings to sort table by that column. *Unless otherwise noted all references are to (Duke, 1992)
Chemical Name Dosage Reference
CHRYSOMYCIN-M 5 ug/l Lorico, A., Long, B. H. 1993. Biochemical Characterisation of Elsamicin and Other Coumarin-Related Antitumor Agents as Potent Inhibitors of Human Topoisomerase II. Eur J Cancer, 29: 1985-1991.
CHRYSOMYCIN-V 1 ug/l Lorico, A., Long, B. H. 1993. Biochemical Characterisation of Elsamicin and Other Coumarin-Related Antitumor Agents as Potent Inhibitors of Human Topoisomerase II. Eur J Cancer, 29: 1985-1991.
CLEROCIDIN 100 uM Kawada, S. Z., Yamashita, Y., Fujii, N., Nakano, H. 1991. Induction of a Heat-Stable Topoisomerase II-DNA Cleavable Complex by Nonintercalative Terpenoids, Terpentecin and Clerocidin. Cancer Research, 51: 2922-2925.
COLUMBIANADIN ID50=10 mM Hu, C. Q., Lee, K. S. 1992. Coumarins From the Roots of Seseli mairei and Inhibition of DNA Topoisomerase II Activity. Tianran Chanwu Yanjiu Yu Kaifa, 4: 6-10.
CORILAGIN IC100=0.5 uM Kashiwada, Y., Nonaka, G. I., Nishioka, I., Lee, J. H., Bori, I., Fukushima, Y., Bastow, K. F., Lee, K. H. 1993. Tannins as Potent Inhibitors of DNA Topoisomerase II in vitro. J Pharm Sci, 82: 487-492.
CRYPTOLEPINE 0.5-50 uM *
CURCUMIN *
CYSTODYTIN-J IC90=8.4 uM McDonald, L. A., et al . 1994. Inhibition of Topoisomerase II Catalytic Activity by Pyridoacridine Alkaloids From a Cystodytes sp. ascidian: A Mechanism for the Apparent Intercalator-Induced Inhibition of Topoisomerase II. J Med Chem, 37: 3819-3827.
DAIDZEIN IC50=3.9 mM Sun, N. J., Woo, S. H., Cassady, J. M., Snapka, R. M. 1998. DNA Polymerase and Topoisomerase II Inhibitors From Psoralea corylifolia. J Natural Products, 61: 362-366.
DAMIRONE-B MIC=400 ug/ml Barrows, L. R., Radisky, D. C., Copp, B. R., Swaffar, D. S., Kramer, R. A., Warters, R. L., Ireland, C. M. 1993. Makaluvamines, Marine Natural Products are Active Anti-Cancer Agents and DNA Topo II Inhibitors. Anticancer Drug Design, 8: 333-347.
DAMNACANTHAL IC50=20 ug/ml Tosa, H., Inuma, M. K., Asai, F., Tanaka, T., Nozaki, H., Ikeda, S., Tsutsui, K., Yamada, M., Fujimori, S. 1998. Anthraquinones From Neonauclea calycina and Their Inhibitory Activity Against DNA Topoisomerase II. Biol Pharm Bull, 21: 641-642.
DEHYDROKUANONIAMINE-B IC90=115 uM McDonald, L. A., et al . 1994. Inhibition of Topoisomerase II Catalytic Activity by Pyridoacridine Alkaloids From a Cystodytes sp. ascidian: A Mechanism for the Apparent Intercalator-Induced Inhibition of Topoisomerase II. J Med Chem, 37: 3819-3827.
DEMETHOXYCURCUMIN *
DEOXYPODOPHYLLOTOXIN IC50=186.5 uM Terada, T., et al. 1992. Antitumor Agents. I. DNA Topoisomerase II Inhibitory Activity and the Structural Relationship of Podophyllotoxin Derivatives as Antitumor Agents. Chem Pharm Bull, 40: 2720-2727.
DEOXYPODOPHYLLOTOXIN 10 ug/ml Figgitt, D. P., Denyer, S. P., Dewick, P. M., Jaackson, D. E., Williams, P. Differential Sensitivity of Fungal Topoisomerases to Podophyllotoxin Derivatives. J Pharm Pharmacol Suppl, 41: 44pp.
DIPLAMINE IC90=9.2 uM McDonald, L. A., et al . 1994. Inhibition of Topoisomerase II Catalytic Activity by Pyridoacridine Alkaloids From a Cystodytes sp. ascidian: A Mechanism for the Apparent Intercalator-Induced Inhibition of Topoisomerase II. J Med Chem, 37: 3819-3827.
ELAEOCARPUSIN IC100=0.5 uM Kashiwada, Y., Nonaka, G. I., Nishioka, I., Lee, J. H., Bori, I., Fukushima, Y., Bastow, K. F., Lee, K. H. 1993. Tannins as Potent Inhibitors of DNA Topoisomerase II in vitro. J Pharm Sci, 82: 487-492.
ELENIC-ACID IC50=0.1 ug/ml Juagdan, E. G., Kalidindi, R. S., Scheuer, P. J., Kelly-Borges, M. 1995. Elenic Acid, an Inhibitor of Topoisomerase II, From a Sponge, Plakinastrella sp. Tetrahedron Letters, 36: 2905-2908.
ELLIPTICINE 20-40 uM *
ELSAMICIN 0.5 ug/l Lorico, A., Long, B. H. 1993. Biochemical Characterisation of Elsamicin and Other Coumarin-Related Antitumor Agents as Potent Inhibitors of Human Topoisomerase II. Eur J Cancer, 29: 1985-1991.
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List of Activity Plants.
Click on column headings to sort table by that column.
Plant Name Common Name Chemical Count Total Parts Per Million
Silybum marianum Milk Thistle; Lady's Thistle 3 0
Simaba obovata 1 0
Smilax china China Root 1 0
Solanum tuberosum Potato 5 0
Solidago gigantea Early Goldenrod 4 0
Solidago virgaurea European Goldenrod; Woundwort 3 0
Sophora japonica Japanese Pagoda Tree 6 434, 000
Sophora subprostrata Shan Dou Gen 2 0
Sorbus americana 1 0
Sorbus aucubaria Rowan Berry 3 0
Spartium junceum Genet; Spanish Broom; Weaver's Broom 2 0
Spinacia oleracea Spinach 3 210
Spondias pinnata Yellow Mombin; Yellow Plum 1 0
Stachys officinalis Betony; Wood Betony; Bishop's-Wort; Purple Betony 1 0
Stauracanthus boivinii 1 0
Stauracanthus genistoides 1 0
Stellaria media Chickweed; Common Chickweed 3 0
Stemonoporus affinis 1 0
Stemonoporus canaliculatus 1 0
Stemonoporus cordifolius 1 0