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Dr. Duke's Phytochemical and Ethnobotanical Databases
U.S. Department of Agriculture
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MDR-Inhibitor

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List of activity chemicals.
Click on column headings to sort table by that column. *Unless otherwise noted all references are to (Duke, 1992)
Chemical Name Dosage Reference
LAHADININE-A IC50=2.5 ug/ml Kam, T. S., Subramaniam, G., Sim, K. M., Yoganathan, K., Koyano, T., Toyoshima, M., Rho, M. C., Hayashi, M., Komiyama, K. 1998. Reversal of Multidrug Resistance (MDR) by Aspidofractinine-Type Indole Alkaloids. Bioorg. Med. Chem. Lett., 8: 2769-2772.
LYCACONITINE IC50=74 ug/ml Kim, D. K., Kwon, H. Y., Lee, K. R., Rhee, D. K., Zee, O. P. 1998. Isolation of a Multidrug Resistance Inhibitor From Aconitum pseudo-laeve var. erectum. Arch Pharm Research, 21: 344-347.
PLEIOCARPINE IC50=3.1 ug/ml Kam, T. S., Subramaniam, G., Sim, K. M., Yoganathan, K., Koyano, T., Toyoshima, M., Rho, M. C., Hayashi, M., Komiyama, K. 1998. Reversal of Multidrug Resistance (MDR) by Aspidofractinine-Type Indole Alkaloids. Bioorg. Med. Chem. Lett., 8: 2769-2772.
PUERARIN *
QUINIDINE IC50=1-12 uM *
QUINIDINE 100 uM Critchfield, J. W., Welsh, C. J., Phang, J. M., Yeh, G. C. 1994. Modulation of Adriamycin Accumulation and Efflux by Flavonoids in HCT-15 Colon Cells. Activation of P-Glycoprotein as a Putative Mechanism. Biochem Pharmacol, 48(7): 1437-1445.
QUININE IC50=4-17 uM *
RESERPINE 2.5-10 uM *
TANGERETIN *
TAXACIN 10 ug/ml Kobayashi, J., et al. 1997. Effects of Taxoids From Taxus cuspidata on Microtubule Depolymerization and Vincristine Accumulation in MDR Cells. Bioorg. Med. Chem. Lett., 7: 393-398.
TAXACUSTIN 1 ug/mL Kobayashi, J., et al. 1997. Effects of Taxoids From Taxus cuspidata on Microtubule Depolymerization and Vincristine Accumulation in MDR Cells. Bioorg. Med. Chem. Lett., 7: 393-398.
TAXAGIFINE 1 ug/mL Kobayashi, J., et al. 1997. Effects of Taxoids From Taxus cuspidata on Microtubule Depolymerization and Vincristine Accumulation in MDR Cells. Bioorg. Med. Chem. Lett., 7: 393-398.
TAXAYUNTIN 1 ug/mL Kobayashi, J., et al. 1997. Effects of Taxoids From Taxus cuspidata on Microtubule Depolymerization and Vincristine Accumulation in MDR Cells. Bioorg. Med. Chem. Lett., 7: 393-398.
TAXCHININ-B 1 ug/mL Kobayashi, J., et al. 1997. Effects of Taxoids From Taxus cuspidata on Microtubule Depolymerization and Vincristine Accumulation in MDR Cells. Bioorg. Med. Chem. Lett., 7: 393-398.
TAXINE-II 1 ug/mL *
TAXININE 1 ug/mL *
TAXININE-A 1 ug/mL *
TAXININE-B 1-10 ug/ml *
TAXININE-M 1 ug/mL Kobayashi, J., et al. 1997. Effects of Taxoids From Taxus cuspidata on Microtubule Depolymerization and Vincristine Accumulation in MDR Cells. Bioorg. Med. Chem. Lett., 7: 393-398.
TAXUSPINE-A 1 ug/mL *
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List of Activity Plants.
Click on column headings to sort table by that column.
Plant Name Common Name Chemical Count Total Parts Per Million
Cologana broussonetii 1 0
Conium maculatum Poison Hemlock; Hemlock; Spotted Hemlock; Fool's Parsley; Carrot Fern; Spotted Parsley 1 240, 000
Costus speciosus Crepe Ginger; Wild Ginger; Cane Reed 1 0
Crotalaria juncea Sunhemp 1 0
Curcuma longa Turmeric; Indian Saffron 1 463, 600
Curcuma xanthorrhiza Javan Turmeric; Temu Lawak 1 20, 000
Curcuma zedoaria Shoti; Zedoary 1 2, 000
Cytisus ardoini 1 0
Cytisus ingramii 1 0
Cytisus multiflorus 1 0
Cytisus scoparius Scotch Broom 1 0
Cytisus striatus 1 0
Cytisus tribracteolatus 1 0
Desmodium gangeticum 1 8
Dictamnus albus Akgiritotu; Burning Bush; Dittany; Gas Plant; Gazelotu 1 0
Dioclea glycinoides 1 15
Dipogon lignosus 1 0
Dolichos biflorus 1 0
Dunbaria villosa 1 13
Echinospartium horridum 1 0