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Dr. Duke's Phytochemical and Ethnobotanical Databases
U.S. Department of Agriculture
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Antimalarial

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List of activity chemicals.
Click on column headings to sort table by that column. *Unless otherwise noted all references are to (Duke, 1992)
Chemical Name Dosage Reference
SECURININE 5.4 ug/ml *
SERGEOLIDE ED50=0.26 mg/kg day Grenand, P., Moretti, C., and Jacquemin, H. 1987. Pharmacopees Traditionnelles en Guyane. l'ORSTROM, Paris. 569 pp.
SIMALIKALACTONE-D IC50=0.001-0.002 ug/ml Rukunga, G. and Simons, A. J. 2006. The Potential of Plants as a Source of Antimalarial Agents - A Review. Africa Herbal Antimalaria Meeting. PlantaPhile Publications, Berlin. 72 pp.
SIPANDINOLIDE IC50=46 ug/ml Rukunga, G. and Simons, A. J. 2006. The Potential of Plants as a Source of Antimalarial Agents - A Review. Africa Herbal Antimalaria Meeting. PlantaPhile Publications, Berlin. 72 pp.
SKIMMIANINE IC50=48.2 ug/ml Khalid, S.A., Farouk, A., Geary**, T.G., and Jensen, J.B. 1985. Potential Antimalarial Candidates From African Plants: An In Vitro Approach Using Plasmodium falciparum*. Journal of Ethnopharmacology, 15: 201-209, 1986.
SUNGUCINE IC50=7.8-10.1 uM Rukunga, G. and Simons, A. J. 2006. The Potential of Plants as a Source of Antimalarial Agents - A Review. Africa Herbal Antimalaria Meeting. PlantaPhile Publications, Berlin. 72 pp.
SWERCHIN Williamson, E. M. and Evans, F. J., Potter's New Cyclopaedia of Botanical Drugs and Preparations, Revised Ed., Saffron Walden, the C. W. Daniel Co., Ltd., Essex UK, 362 pp, 1988, reprint 1989.
TALCARPINE IC50=40.3 uM Rukunga, G. and Simons, A. J. 2006. The Potential of Plants as a Source of Antimalarial Agents - A Review. Africa Herbal Antimalaria Meeting. PlantaPhile Publications, Berlin. 72 pp.
TERMILIGNAN IC50=6-9 uM Rukunga, G. and Simons, A. J. 2006. The Potential of Plants as a Source of Antimalarial Agents - A Review. Africa Herbal Antimalaria Meeting. PlantaPhile Publications, Berlin. 72 pp.
THALIFABERIDINE IC50=0.12-0.88 ug/ml Rukunga, G. and Simons, A. J. 2006. The Potential of Plants as a Source of Antimalarial Agents - A Review. Africa Herbal Antimalaria Meeting. PlantaPhile Publications, Berlin. 72 pp.
THALIFABERINE IC50=0.44-5.1 ug/ml Rukunga, G. and Simons, A. J. 2006. The Potential of Plants as a Source of Antimalarial Agents - A Review. Africa Herbal Antimalaria Meeting. PlantaPhile Publications, Berlin. 72 pp.
THALIFASINE IC50=0.05-0.24 ug/ml Rukunga, G. and Simons, A. J. 2006. The Potential of Plants as a Source of Antimalarial Agents - A Review. Africa Herbal Antimalaria Meeting. PlantaPhile Publications, Berlin. 72 pp.
TILIACORINE IC50=0.67 ug/ml *
TILIACORININE IC50=3.5 ug/ml *
TOMENTOSRIN IC50=7.8 ug/ml Rukunga, G. and Simons, A. J. 2006. The Potential of Plants as a Source of Antimalarial Agents - A Review. Africa Herbal Antimalaria Meeting. PlantaPhile Publications, Berlin. 72 pp.
TOTAQUINE 600 mg/3x/day/man Martindale's 29th
TRANS-PINOCARVEOL IC50=5-50 ug/ml Rukunga, G. and Simons, A. J. 2006. The Potential of Plants as a Source of Antimalarial Agents - A Review. Africa Herbal Antimalaria Meeting. PlantaPhile Publications, Berlin. 72 pp.
TRANS-PINOCARVYL-HYDROPEROXIDE IC50=7.5 ug/ml Rukunga, G. and Simons, A. J. 2006. The Potential of Plants as a Source of Antimalarial Agents - A Review. Africa Herbal Antimalaria Meeting. PlantaPhile Publications, Berlin. 72 pp.
TRICHIRUBRINE-A IC50=0.3 ug/ml Rukunga, G. and Simons, A. J. 2006. The Potential of Plants as a Source of Antimalarial Agents - A Review. Africa Herbal Antimalaria Meeting. PlantaPhile Publications, Berlin. 72 pp.
TRIGILLETIMINE IC50=22 ug/ml (ca 1/200 x chloroquine) *
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List of Activity Plants.
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Plant Name Common Name Chemical Count Total Parts Per Million
Phaseolus aborigineus 1 0
Phaseolus vulgaris Black Bean; Green Bean; Haricot Bean; Garden Bean; String Bean; Dwarf Bean; Field Bean; Flageolet Bean; French Bean; Kidney Bean; Navy Bean; Pop Bean; Popping Bean; Snap Bean; Wax Bean; Haricot Vert; Haricot 1 0
Phellodendron amurense Huang Po; Po Mu; Amur Cork Tree; Huang Bai 4 80, 000
Phoenix dactylifera Date Palm 3 0
Phoradendron juniperinum 1 3
Phyllanthus amarus 2 1, 588
Phyllanthus discoideus 1 0
Phyllanthus emblica Emblic; Myrobalan 4 119, 900
Phyllanthus niruri Seed On The Leaf 3 0
Phyllanthus reticulatus 1 3.299999952316284
Physalis peruviana Cape Gooseberry; Ground Cherry 1 0
Phytolacca americana Pokeweed 1 0
Picramnia sellowii 1 0
Pilocarpus microphyllus Maranhao Jaborandi 1 100
Pimenta dioica Allspice; Jamaica-Pepper; Pimenta; Clover-Pepper; Pimento 2 1, 800
Pimpinella anisum Anise; Sweet Cumin 3 0
Pinus mugo Dwarf Pine; Swiss Mountain Pine 1 0
Pinus sylvestris Scotch Pine 3 0
Piper auritum Cordoncillo; Hierba Santa; Hoja Santa 1 0
Piper cubeba Cubeb; Cubeb Pepper 2 85, 200