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Dr. Duke's Phytochemical and Ethnobotanical Databases
U.S. Department of Agriculture
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Antimalarial

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List of activity chemicals.
Click on column headings to sort table by that column. *Unless otherwise noted all references are to (Duke, 1992)
Chemical Name Dosage Reference
SECURININE 5.4 ug/ml *
SERGEOLIDE ED50=0.26 mg/kg day Grenand, P., Moretti, C., and Jacquemin, H. 1987. Pharmacopees Traditionnelles en Guyane. l'ORSTROM, Paris. 569 pp.
SIMALIKALACTONE-D IC50=0.001-0.002 ug/ml Rukunga, G. and Simons, A. J. 2006. The Potential of Plants as a Source of Antimalarial Agents - A Review. Africa Herbal Antimalaria Meeting. PlantaPhile Publications, Berlin. 72 pp.
SIPANDINOLIDE IC50=46 ug/ml Rukunga, G. and Simons, A. J. 2006. The Potential of Plants as a Source of Antimalarial Agents - A Review. Africa Herbal Antimalaria Meeting. PlantaPhile Publications, Berlin. 72 pp.
SKIMMIANINE IC50=48.2 ug/ml Khalid, S.A., Farouk, A., Geary**, T.G., and Jensen, J.B. 1985. Potential Antimalarial Candidates From African Plants: An In Vitro Approach Using Plasmodium falciparum*. Journal of Ethnopharmacology, 15: 201-209, 1986.
SUNGUCINE IC50=7.8-10.1 uM Rukunga, G. and Simons, A. J. 2006. The Potential of Plants as a Source of Antimalarial Agents - A Review. Africa Herbal Antimalaria Meeting. PlantaPhile Publications, Berlin. 72 pp.
SWERCHIN Williamson, E. M. and Evans, F. J., Potter's New Cyclopaedia of Botanical Drugs and Preparations, Revised Ed., Saffron Walden, the C. W. Daniel Co., Ltd., Essex UK, 362 pp, 1988, reprint 1989.
TALCARPINE IC50=40.3 uM Rukunga, G. and Simons, A. J. 2006. The Potential of Plants as a Source of Antimalarial Agents - A Review. Africa Herbal Antimalaria Meeting. PlantaPhile Publications, Berlin. 72 pp.
TERMILIGNAN IC50=6-9 uM Rukunga, G. and Simons, A. J. 2006. The Potential of Plants as a Source of Antimalarial Agents - A Review. Africa Herbal Antimalaria Meeting. PlantaPhile Publications, Berlin. 72 pp.
THALIFABERIDINE IC50=0.12-0.88 ug/ml Rukunga, G. and Simons, A. J. 2006. The Potential of Plants as a Source of Antimalarial Agents - A Review. Africa Herbal Antimalaria Meeting. PlantaPhile Publications, Berlin. 72 pp.
THALIFABERINE IC50=0.44-5.1 ug/ml Rukunga, G. and Simons, A. J. 2006. The Potential of Plants as a Source of Antimalarial Agents - A Review. Africa Herbal Antimalaria Meeting. PlantaPhile Publications, Berlin. 72 pp.
THALIFASINE IC50=0.05-0.24 ug/ml Rukunga, G. and Simons, A. J. 2006. The Potential of Plants as a Source of Antimalarial Agents - A Review. Africa Herbal Antimalaria Meeting. PlantaPhile Publications, Berlin. 72 pp.
TILIACORINE IC50=0.67 ug/ml *
TILIACORININE IC50=3.5 ug/ml *
TOMENTOSRIN IC50=7.8 ug/ml Rukunga, G. and Simons, A. J. 2006. The Potential of Plants as a Source of Antimalarial Agents - A Review. Africa Herbal Antimalaria Meeting. PlantaPhile Publications, Berlin. 72 pp.
TOTAQUINE 600 mg/3x/day/man Martindale's 29th
TRANS-PINOCARVEOL IC50=5-50 ug/ml Rukunga, G. and Simons, A. J. 2006. The Potential of Plants as a Source of Antimalarial Agents - A Review. Africa Herbal Antimalaria Meeting. PlantaPhile Publications, Berlin. 72 pp.
TRANS-PINOCARVYL-HYDROPEROXIDE IC50=7.5 ug/ml Rukunga, G. and Simons, A. J. 2006. The Potential of Plants as a Source of Antimalarial Agents - A Review. Africa Herbal Antimalaria Meeting. PlantaPhile Publications, Berlin. 72 pp.
TRICHIRUBRINE-A IC50=0.3 ug/ml Rukunga, G. and Simons, A. J. 2006. The Potential of Plants as a Source of Antimalarial Agents - A Review. Africa Herbal Antimalaria Meeting. PlantaPhile Publications, Berlin. 72 pp.
TRIGILLETIMINE IC50=22 ug/ml (ca 1/200 x chloroquine) *
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List of Activity Plants.
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Plant Name Common Name Chemical Count Total Parts Per Million
Ocimum canum Hoary Basil 3 0
Ocimum gratissimum Agbo; Shrubby Basil 2 1, 140
Ocimum suave Kenyan Tree Basil 1 0
Ocimum tenuiflorum Anise-Scented Basil 3 7, 090
Oenanthe aquatica Water Fennel; Water Hemlock 1 0
Oenanthe crocata Water Dropwort 1 0
Oenothera biennis Evening-Primrose 3 207, 000
Olea europaea Olive 5 0
Ononis spinosa Spiny Restharrow; Restharrow; Hauhechel (Ger.) 1 0
Opopanax chironium Hercules All Heal; Opopanax 1 0
Opuntia ficus-indica Indian Fig; Prickly Pear; Nopal; Nopalito 1 0
Origanum compactum 1 70
Origanum majorana Marjoram; Sweet Marjoram 4 13, 600
Origanum onites Oregano; Pot Marjoram 1 40
Origanum vulgare Common Turkish Oregano; Wild Oregano; Oregano; Pot Marjoram; Wild Marjoram; European Oregano 4 18, 600
Paeonia japonica 1 5, 000
Paeonia lactiflora Chih-Shao; Peony; Common Garden Peony; White Peony; Bai Shao (Chinese) 1 0
Paeonia moutan Moutan; Tree Peony 1 0
Paeonia suffruticosa Moutan; Tree Peony; Moutan Peony 1 0
Palaquium grande 1 7