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Dr. Duke's Phytochemical and Ethnobotanical Databases
U.S. Department of Agriculture
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Aldose-Reductase-Inhibitor

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List of activity chemicals.
Click on column headings to sort table by that column. *Unless otherwise noted all references are to (Duke, 1992)
Chemical Name Dosage Reference
TRIFOLIN IC19=1 uM *
TRIFOLIN IC62=10 uM Shimizu, M., Ito, T., Terashima, S., Hayashi, T., Arisawa, M., Morita, N., Kurokawa, S., Ito, K., and Hashimoto, Y. 1984. Inhibition of Lens Aldose Reductase by Flavonoids. Phytochemistry, 23: 1885-1888.
UMBELLIFERONE IC50=4.8 ug/ml cow Okada,Y,et al.1995.Search for Naturally Occurring Substances to Prevent the Complications of Diabetes.II.Inhibitory Effect of Coumarin and Flavonoid Derivatives on Bovine Lens Aldose Reductase and Rabbit Platelet Aggregation.Chem Pharm Bull43(8):1385-1387
VANILLIC-ACID 100 uM/l *
VERBASCOSIDE IC50=0.39-15.1 uM *
VITEXICARPIN 100 uM/l *
VITEXIN IC15=10 uM Shimizu, M., Ito, T., Terashima, S., Hayashi, T., Arisawa, M., Morita, N., Kurokawa, S., Ito, K., and Hashimoto, Y. 1984. Inhibition of Lens Aldose Reductase by Flavonoids. Phytochemistry, 23: 1885-1888.
VITEXIN 5 ug/ml Okamot, Y., Yoshizawa, T. 1994. Angiotensin-Converting Enzyme Inhibitors and Aldose Reductase Inhibitors Containing Passiflora quadraqularis Extracts or Vitexin. Patent, Japan Kokai Tokkyo Koho-06,293,657. 4pp.
WARANGALONE 10 uM Iinuma, M., Tanaka, T., Mizuno, M., Katsuzaki, T., Ogawa, H. 1989. Structure-Activity Correlation of Flavonoids for Inhibition of Bovine Lens Aldose Reductase. Chem Pharm Bull, 37(7): 1813-1815.
WOGONIN IC13=10uM Shimizu, M., Ito, T., Terashima, S., Hayashi, T., Arisawa, M., Morita, N., Kurokawa, S., Ito, K., and Hashimoto, Y. 1984. Inhibition of Lens Aldose Reductase by Flavonoids. Phytochemistry, 23: 1885-1888.
WOGONIN IC50=48 uM rat Shin, K. H., Chae, Y. J., Chung, M. S., Lee, H. J. 1994. Effect of Flavonoids from Scutellariae radix on Cataract Formation and Polyol Accumulation in Rat Lens. Korean J Pharmacog, 25(1): 41-46.
WOGONIN-7-O-GLUCURONIDE IC50=40 uM rat Shin, K. H., Chae, Y. J., Chung, M. S., Lee, H. J. 1994. Effect of Flavonoids from Scutellariae radix on Cataract Formation and Polyol Accumulation in Rat Lens. Korean J Pharmacog, 25(1): 41-46.
WOGONIN-7-O-GLUCURONIDE-METHYL-ESTER IC50=39 uM rat Shin, K. H., Chae, Y. J., Chung, M. S., Lee, H. J. 1994. Effect of Flavonoids from Scutellariae radix on Cataract Formation and Polyol Accumulation in Rat Lens. Korean J Pharmacog, 25(1): 41-46.
XANTHOMICROL 10 uM Okuda, I., Muwa, B., Inagakat, K., Horie, T., Nakayama, M. 1982. Inhibition of Aldose Reductases from Rat and Bovine Lenses by Flavonoids. Biochem Pharmacol, 31(23): 3807-3822.
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List of Activity Plants.
Click on column headings to sort table by that column.
Plant Name Common Name Chemical Count Total Parts Per Million
Cucumis melo Cantaloupe; Melon; Muskmelon; Netted Melon; Persian Melon; Nutmeg Melon 4 26, 220
Cucumis sativus Cucumber 2 0
Cucurbita pepo Pumpkin 5 6, 844
Cucurbita spp Summer Squash 1 2, 340
Cuminum cyminum Cumin 11 174, 336
Cunila origanoides Mountain Dittany; Frost Flower; Frost Mint; Maryland Dittany; American Dittany; Stone Mint; Dittany 4 63, 112
Curcuma longa Turmeric; Indian Saffron 10 29, 266
Cuscuta reflexa Amarbel 2 0
Cyamopsis tetragonoloba Guar; Cluster-Bean; Siam-Bean 9 9, 870
Cyclanthera pedata Achocha 1 2, 800
Cydonia oblonga Quince 3 960
Cymbopogon citratus West Indian Lemongrass; Lemongrass 6 7, 200
Cymbopogon flexuosus East Indian Lemongrass 1 0
Cymbopogon nardus Ceylon Citronella; Citronella 4 912
Cymbopogon parkeri Skhabar 2 70
Cymbopogon winterianus Java Citronella; Mahapengiri 2 294
Cynara cardunculus Artichoke 12 828
Cyperus rotundus Nutsedge 1 90
Cyphomandra betacea Tamarillo; Tree Tomato 1 4, 120
Cyrtosperma chamissonis Swamp Taro 1 762