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Chemical ID
COUMARIN
Ubiquitous
No
| Dosage | Reference |
|---|---|
| LD50=202 (orl gpg) | Merck 11th Edition |
| LD50=293 (orl rat) | CRC Handbook of Medicinal Herbs and/or CRC Handbook of Proximate Analyses, Zebovitz, T. C. Ed. 1989. Part VII. Flavor and Fragrance Substances, in Keith L. H. and Walters, D.B., eds. Compendium of Safety Data Sheets for Research and Industrial Chemicals. VCH Publishers, New York. 3560-4253. |
| LD50=680 (orl rat) | Merck 11th Edition |
| LD50=720 (orl rat) |
| Activity | Dosage | Reference |
|---|---|---|
| Aldose-Reductase-Inhibitor | 10 ug/ml cow (weak activity, 11% inhibition) | Okada,Y,et al.1995.Search for Naturally Occurring Substances to Prevent the Complications of Diabetes.II.Inhibitory Effect of Coumarin and Flavonoid Derivatives on Bovine Lens Aldose Reductase and Rabbit Platelet Aggregation.Chem Pharm Bull43(8):1385-1387 |
| Allelochemic | IC100=2 mM | Lydon, J. & Duke, S., The potential of pesticides from plants, pp. 1-41 in Craker, L. & Simon, J., eds, Herbs, Spices & Medicinal Plants: Recent Advances in Botany, Horticulture, & Pharmacology, v. 4, Oryx Press, Phoenix, 1989, 267pp. |
| Analgesic | not available | Zebovitz, T. C. Ed. 1989. Part VII. Flavor and Fragrance Substances, in Keith L. H. and Walters, D.B., eds. Compendium of Safety Data Sheets for Research and Industrial Chemicals. VCH Publishers, New York. 3560-4253. |
| Anesthetic | not available | Duke, 1992 * |
| Antiaggregant | not available | Duke, 1992 * |
| Antiandrogenic | not available | Planta Medica, 56(6): 671, 1990. |
| Antibrucellosic | not available | Gawron, A., Gorski*, G., Glowniak**, K. 1989. Increased proliferation of phytohaemagglutinin (PHA)-stimulated human leucocytes after 8-methoxypsoralen treatment. J. Pharm. Pharmacol. 42: 194-195, 1990. |
| Anticancer (Kidney) | 400-7,000 mg/day | Mills, Simon and Bone, Kerry. 2000. Phytotherapy. Churchill Livinston, Edinburgh. |
| Anticancer (Prostate) | 400-7,000 mg/day | Mills, Simon and Bone, Kerry. 2000. Phytotherapy. Churchill Livinston, Edinburgh. |
| Antidiuretic | not available | Duke, 1992 * |
| Antiedemic | not available | Shimizu,*M., et al. 1990. Anti-inflammatory Constituents of Topically Applied Crude Drugs. IV.1) Constituents and Anti-inflammatory Effect of Paraguayan Crude Drug 'Alhucema' (Lavandula latifolia Vill.)2). Chem. Pharm. Bull. 38(8): 2283-2284, 1990. |
| Antiesherichic | not available | Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp. |
| Antiinflammatory | not available | Shimizu,*M., et al. 1990. Anti-inflammatory Constituents of Topically Applied Crude Drugs. IV.1) Constituents and Anti-inflammatory Effect of Paraguayan Crude Drug 'Alhucema' (Lavandula latifolia Vill.)2). Chem. Pharm. Bull. 38(8): 2283-2284, 1990. |
| Antilymphedemic | not available | Mills, Simon and Bone, Kerry. 2000. Phytotherapy. Churchill Livinston, Edinburgh. |
| Antimelanomic | 50 mg/day | Duke, 1992 * |
| Antimetastatic | 50 mg/man/day | Mills, Simon and Bone, Kerry. 2000. Phytotherapy. Churchill Livinston, Edinburgh. |
| Antimitotic | not available | Pandeya, S.N. 1970. Biological Activity of Adamantyl Derivatives. The Indian Journal of Pharmacy, 33: 7. |
| Antimononuccleotic | not available | Mills, Simon and Bone, Kerry. 2000. Phytotherapy. Churchill Livinston, Edinburgh. |
| Antimutagenic | not available | Economic & Medicinal Plant Research, 6: 235. |
| Antimycoplasmotic | not available | Mills, Simon and Bone, Kerry. 2000. Phytotherapy. Churchill Livinston, Edinburgh. |
| Plant Name | Plant Part | Low Parts Per Million | High Parts Per Million | Standard Deviation | Reference |
|---|---|---|---|---|---|
| Melilotus officinalis | Stem | not available | not available | not available | Duke, 1992 * |
| Melilotus officinalis | Flower | not available | not available | not available | Duke, 1992 * |
| Mentha x piperita | Leaf | 0.0 | 0.2 | -1.0 | Duke, J. A. Writeups or information summaries on approximately 2,000 economic plants, USDA, ARS, Beltsville, MD 20705. |
| Myroxylon balsamum | Seed | not available | 4000.0 | -1.0 | Duke, 1992 * |
| Petiveria alliacea | Root | not available | not available | not available | List, P.H. and Horhammer, L., Hager's Handbuch der Pharmazeutischen Praxis, Vols. 2-6, Springer-Verlag, Berlin, 1969-1979. |
| Peumus boldus | Leaf | 100.0 | 5000.0 | -0.2 | Duke, 1992 * |
| Phoenix dactylifera | Leaf | not available | not available | not available | Morton, J.F., Major Medicinal Plants. 1977. Atlas of Medicinal Plants of Middle America. Bahamas to Yucatan. 1981. |
| Prunus cerasus | Plant | not available | not available | not available | Duke, 1992 * |
| Psoralea corylifolia | Seed | not available | not available | not available | Duke, 1992 * |
| Ptychopetalum olacoides | Root | not available | not available | not available | Toyota, A., Ninomiya, R., Kobayashi, H., Kawanishi, K., Uhara, Y., Kato, A., Hashimoto, Y. 1979. Studies of Brazilian Crude Drugs. 1. Muira-Puama. Shoyakugaku Zasshi, 33: 57-64. |
| Tecoma stans | Bark | not available | 80.0 | not available | Duke, 1992 * |
| Theobroma cacao | Seed | not available | not available | not available | Grenand, P., Moretti, C., and Jacquemin, H. 1987. Pharmacopees Traditionnelles en Guyane. l'ORSTROM, Paris. 569 pp. |
| Thymus vulgaris | Essential Oil | not available | 3000.0 | not available | Duke, 1992 * |
| Trifolium pratense | Flower | not available | 22.0 | not available | Buchnauer,G.,Jirovetz,L.,Nikiforov,A.1996.Comparative Investigation of Essential Clover Flower Oils from Austria Using Gas Chromatography-Flame Ionization Detection,Gas Chromatography-Mass Spectometry,and Gas Chrom.-Olfactometry.J.Agrc.Food Chem.44:1827-8 |
| Trigonella foenum-graecum | Seed | not available | not available | not available | Duke, 1992 * |
| Trigonella foenum-graecum | Plant | not available | not available | not available | Newall, C. A., Anderson, L. A. and Phillipson, J. D. 1996. Herbal Medicine - A Guide for Health-care Professionals. The Pharmaceutical Press, London. 296pp. |
| Trilisa odoratissima | Leaf | not available | 16000.0 | 1.7 | Leung, A. Y. and Foster, S. 1995. Encyclopedia of Common Natural Ingredients 2nd Ed. John Wiley & Sons, New York. 649 pp. |
| Urtica dioica | Plant | not available | not available | not available | Newall, C. A., Anderson, L. A. and Phillipson, J. D. 1996. Herbal Medicine - A Guide for Health-care Professionals. The Pharmaceutical Press, London. 296pp. |
| Vanilla planifolia | Fruit | not available | 6100.0 | not available | Duke, 1992 * |
| Verbascum thapsus | Leaf | not available | not available | not available | ANON. 1948-1976. The Wealth of India raw materials. Publications and Information Directorate, CSIR, New Delhi. 11 volumes. |