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Dr. Duke's Phytochemical and Ethnobotanical Databases
U.S. Department of Agriculture
  1. Home
  2. APIGENIN

APIGENIN

Chemical ID
APIGENIN
Ubiquitous
No

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List of chemical activities.
Click on column headings to sort table by that column. *Unless otherwise noted all references are to (Duke, 1992)
Activity Dosage Reference
Ornithine-Decarboxylase-Inhibitor *
P21-Inducer 10-70 uM *
Pesticide *
PKC-Inhibitor IC50=10 uM *
Polyamine-Synthesis-Inhibitor *
Progestational *
Protein-Kinase-C-Inhibitor IC50=10-40 uM *
PTK-Inhibitor 10-100 uM *
Quinone-Reductase-Inducer 20 uM Uda, Y., Price, K. R., Williamson, G., Rhodes, M. J. C. 1997. Induction of the Anticarcinogenic Marker Enzyme, Quinone Reductase, in Murine Hepatoma Cells In Vitro by Flavonoids. Cancer Lett., 120 (2): 213-216.
Radioprotective *
Sedative 30-100 mg/kg *
Sunscreen *
TNF-alpha-Inhibitor IC50=3.27 uM *
Topoisomerase-I-Inhibitor Santti, R., Makela, S., Strauss, L., Korman, J., Kostian, M. L. 1998. Phytoestrogens: Potential Endocrine Disruptors in Males. Toxicol Ind Health, 14: 223-237.
Topoisomerase-II-Inhibitor IC28=18 uM *
Topoisomerase-II-Inhibitor IC45=180 uM *
Topoisomerase-II-Inhibitor 50 ug/ml Azuma, Y., Onishi, Y., Sato, Y., Kizaki, H. 1995. Effects of Protein Tyrosine Kinase Inhibitors With Different Modes of Action on Topoisomerase Activity and Death of IL-2-Dependent CTLL-2-Cells. J Biochemistry, 118: 312-318.
Uterotrophic EC50=0.1-25 uM/l Journal of Medicinal Food 2: 227.1999.
Vasodilator *
VEGF-Inhibitor IC50=2-7 uM *
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List of chemical plants.
Click on column headings to sort table by that column. *Unless otherwise noted all references are to (Duke, 1992)
Plant Name Plant Part Low Parts Per Million High Parts Per Million Standard Deviation Reference
Conyza canadensis Plant *
Coriandrum sativum Fruit Williamson, E. M. and Evans, F. J., Potter's New Cyclopaedia of Botanical Drugs and Preparations, Revised Ed., Saffron Walden, the C. W. Daniel Co., Ltd., Essex UK, 362 pp, 1988, reprint 1989.
Crataegus laevigata Leaf *
Crataegus laevigata Fruit Newall, C. A., Anderson, L. A. and Phillipson, J. D. 1996. Herbal Medicine - A Guide for Health-care Professionals. The Pharmaceutical Press, London. 296pp.
Crataegus laevigata Bud *
Crataegus monogyna Flower *
Crataegus monogyna Leaf *
Crataegus monogyna Fruit Newall, C. A., Anderson, L. A. and Phillipson, J. D. 1996. Herbal Medicine - A Guide for Health-care Professionals. The Pharmaceutical Press, London. 296pp.
Crataegus rhipidophylla Bud *
Crataegus rhipidophylla Fruit Newall, C. A., Anderson, L. A. and Phillipson, J. D. 1996. Herbal Medicine - A Guide for Health-care Professionals. The Pharmaceutical Press, London. 296pp.
Crataegus rhipidophylla Leaf *
Cynara cardunculus Leaf Jim Duke's personal files.
Daphne genkwa Flower *
Daucus carota Fruit *
Digitalis purpurea Flower *
Echinacea angustifolia Leaf Leung, A. Y. and Foster, S. 1995. Encyclopedia of Common Natural Ingredients 2nd Ed. John Wiley & Sons, New York. 649 pp.
Echinacea spp Leaf Economic & Medicinal Plant Research, 5: 253.
Ephedra sinica Shoot Jim Duke's personal files.
Equisetum arvense Plant Bisset, N.G., ed. 1994. Herbal Drugs and Phytopharmaceuticals. CRC Press. Boca Raton, FL. 566 pp.
Eucalyptus globulus Leaf *