An official website of the United States government.

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

Dr. Duke's Phytochemical and Ethnobotanical Databases
U.S. Department of Agriculture
  1. Home
  2. Topoisomerase-II-Inhibitor

Topoisomerase-II-Inhibitor

Download these results as:
CSV
EXCEL
PDF
List of activity chemicals.
Click on column headings to sort table by that column. *Unless otherwise noted all references are to (Duke, 1992)
Chemical Name Dosage Reference
GOSSYPOL 3.4 uM *
HAMAMELITANNIN IC100=100 uM Kashiwada, Y., Nonaka, G. I., Nishioka, I., Lee, J. H., Bori, I., Fukushima, Y., Bastow, K. F., Lee, K. H. 1993. Tannins as Potent Inhibitors of DNA Topoisomerase II in vitro. J Pharm Sci, 82: 487-492.
HERBIMYCIN-A 10 ug/ml Azuma, Y., Onishi, Y., Sato, Y., Kizaki, H. 1995. Effects of Protein Tyrosine Kinase Inhibitors With Different Modes of Action on Topoisomerase Activity and Death of IL-2-Dependent CTLL-2-Cells. J Biochemistry, 118: 312-318.
ISOQUERCITRIN 550 ug/ml Bernard, F. X., Sable, S., Cameron, B., Provost, J., Desnottes, J. F., Crouzet, J., Blanche, F. 1997. Glycosylated Flavones as Selective Inhibitors of Topoisomerase IV. Antimicrobial Agents & Chemotherapy, 41: 992-998.
ISORABDOSIIN 50 uM Kashiwada, Y., Bastow, K. F., Lee, K. H. 1995. Novel Lignan Derivatives as Selective Inhibitors of DNA Topoisomerase II. Bioorg Med Chem Lett, 5: 905-908.
KAEMPFEROL IC50=8.1 ug/ml Constantinou, A., Mehta, R., Runyan, C., Rao, K., Vaughan, A., Moon, R. 1995. Flavonoids as DNA Topoisomerase Antagonists and Poisons: Structure-Activity Relationships. J Natural Products, 58: 217-225.
KUANONIAMINE-D IC90=127 uM McDonald, L. A., et al . 1994. Inhibition of Topoisomerase II Catalytic Activity by Pyridoacridine Alkaloids From a Cystodytes sp. ascidian: A Mechanism for the Apparent Intercalator-Induced Inhibition of Topoisomerase II. J Med Chem, 37: 3819-3827.
LIRIODENINE IC50=0.11 uM *
MAKALUVAMINE-A IC50=41 uM Radisky, D. C., Radisky, E. S., Barrows, L. R., Copp, B. R., Kramer, R. A., Ireland, C. M. 1993. Novel Cytotoxic Topoisomerase II Inhibiting Pyrroloiminoquinones From Fijian Sponges of the Genus Zyzzya. J Amer Chem Soc, 115: 1632-1638.
MAKALUVAMINE-A MIC=13 ug/ml Barrows, L. R., Radisky, D. C., Copp, B. R., Swaffar, D. S., Kramer, R. A., Warters, R. L., Ireland, C. M. 1993. Makaluvamines, Marine Natural Products are Active Anti-Cancer Agents and DNA Topo II Inhibitors. Anticancer Drug Design, 8: 333-347.
MAKALUVAMINE-B IC50=420 uM Radisky, D. C., Radisky, E. S., Barrows, L. R., Copp, B. R., Kramer, R. A., Ireland, C. M. 1993. Novel Cytotoxic Topoisomerase II Inhibiting Pyrroloiminoquinones From Fijian Sponges of the Genus Zyzzya. J Amer Chem Soc, 115: 1632-1638.
MAKALUVAMINE-B MIC=400 ug/ml Barrows, L. R., Radisky, D. C., Copp, B. R., Swaffar, D. S., Kramer, R. A., Warters, R. L., Ireland, C. M. 1993. Makaluvamines, Marine Natural Products are Active Anti-Cancer Agents and DNA Topo II Inhibitors. Anticancer Drug Design, 8: 333-347.
MAKALUVAMINE-C MIC=133 ug/ml Barrows, L. R., Radisky, D. C., Copp, B. R., Swaffar, D. S., Kramer, R. A., Warters, R. L., Ireland, C. M. 1993. Makaluvamines, Marine Natural Products are Active Anti-Cancer Agents and DNA Topo II Inhibitors. Anticancer Drug Design, 8: 333-347.
MAKALUVAMINE-D IC50=320 uM Radisky, D. C., Radisky, E. S., Barrows, L. R., Copp, B. R., Kramer, R. A., Ireland, C. M. 1993. Novel Cytotoxic Topoisomerase II Inhibiting Pyrroloiminoquinones From Fijian Sponges of the Genus Zyzzya. J Amer Chem Soc, 115: 1632-1638.
MAKALUVAMINE-D MIC=133 ug/ml Barrows, L. R., Radisky, D. C., Copp, B. R., Swaffar, D. S., Kramer, R. A., Warters, R. L., Ireland, C. M. 1993. Makaluvamines, Marine Natural Products are Active Anti-Cancer Agents and DNA Topo II Inhibitors. Anticancer Drug Design, 8: 333-347.
MAKALUVAMINE-E IC50=310 uM Radisky, D. C., Radisky, E. S., Barrows, L. R., Copp, B. R., Kramer, R. A., Ireland, C. M. 1993. Novel Cytotoxic Topoisomerase II Inhibiting Pyrroloiminoquinones From Fijian Sponges of the Genus Zyzzya. J Amer Chem Soc, 115: 1632-1638.
MAKALUVAMINE-E MIC=133 ug/ml Barrows, L. R., Radisky, D. C., Copp, B. R., Swaffar, D. S., Kramer, R. A., Warters, R. L., Ireland, C. M. 1993. Makaluvamines, Marine Natural Products are Active Anti-Cancer Agents and DNA Topo II Inhibitors. Anticancer Drug Design, 8: 333-347.
MAKALUVAMINE-F MIC=13 ug/ml Barrows, L. R., Radisky, D. C., Copp, B. R., Swaffar, D. S., Kramer, R. A., Warters, R. L., Ireland, C. M. 1993. Makaluvamines, Marine Natural Products are Active Anti-Cancer Agents and DNA Topo II Inhibitors. Anticancer Drug Design, 8: 333-347.
MAKALUVAMINE-F IC50=25 uM Radisky, D. C., Radisky, E. S., Barrows, L. R., Copp, B. R., Kramer, R. A., Ireland, C. M. 1993. Novel Cytotoxic Topoisomerase II Inhibiting Pyrroloiminoquinones From Fijian Sponges of the Genus Zyzzya. J Amer Chem Soc, 115: 1632-1638.
MAKALUVAMINE-N 5 ug/ml Venables, D. A., Concepcion, G. P., Matsumoto, S. S., Barrows, L. R., Ireland, C. M. 1997. Makaluvamine N: A New Pyrroloiminoquinone From Zyzzya fuliginosa. J Natural Products, 60: 408-410.
Download these results as:
CSV
EXCEL
PDF
List of Activity Plants.
Click on column headings to sort table by that column.
Plant Name Common Name Chemical Count Total Parts Per Million
Teline sp 1 0
Tephrosia purpurea Purple Tephrosia; Wild Indigo 1 0
Terminalia arjuna Arjun; Arjuna 5 1, 925.3999729156494
Terminalia bellirica Beleric Myrobalan; Bahera; Myrobalan Belleric; Myrobalan; Belleric 2 0
Terminalia catappa Indian Almond; Tropical Almond; Malabar Almond 7 18, 305.699981689453
Terminalia chebula Ink Nut; Myrobalan; Black Myrobalan; Chebulic Myrobalan 9 309, 079.59924316406
Terminalia ivorensis Idigbo; Emire; Blackbark; Black Afara; Brimstonewood; Satinwood; Shinglewood 1 0
Tetracera akara 1 450
Tetracera indica 1 100
Tetracera sarmentosa 1 700
Tetracera scandens 1 300
Teucrium botrys Field Germander 2 0
Teucrium chamaedrys Wall Germander 1 0
Teucrium montanum Mountain Germander 2 0
Teucrium polium Golden Germander 2 0
Teucrium scordium Water Germander 3 0
Teucrium scorodonia Germander; Wood Germander 2 0
Teyleria koordersii 1 40
Theobroma angustifolium Castarica; Emerald Cacao 1 382
Theobroma bicolor Nicaraguan Cacao; Pataste 1 1, 408