| 4'-DEMETHYLPODOPHYLLOTOXIN |
10 ug/ml |
Figgitt, D. P., Denyer, S. P., Dewick, P. M., Jaackson, D. E., Williams, P. Differential Sensitivity of Fungal Topoisomerases to Podophyllotoxin Derivatives. J Pharm Pharmacol Suppl, 41: 44pp. |
| 4,5-DI-O-GALLOYL-QUINIC-ACID |
IC100=100 uM |
Kashiwada, Y., Nonaka, G. I., Nishioka, I., Lee, J. H., Bori, I., Fukushima, Y., Bastow, K. F., Lee, K. H. 1993. Tannins as Potent Inhibitors of DNA Topoisomerase II in vitro. J Pharm Sci, 82: 487-492. |
| 5-METHYLPSORALEN |
ID50=10 mM |
Hu, C. Q., Lee, K. S. 1992. Coumarins From the Roots of Seseli mairei and Inhibition of DNA Topoisomerase II Activity. Tianran Chanwu Yanjiu Yu Kaifa, 4: 6-10. |
| ACETYL-UMBELLIFERONE |
ID50=10 mM |
Hu, C. Q., Lee, K. S. 1992. Coumarins From the Roots of Seseli mairei and Inhibition of DNA Topoisomerase II Activity. Tianran Chanwu Yanjiu Yu Kaifa, 4: 6-10. |
| ACLACINOMYCIN-A |
7 uM |
Rappa, G., Lorico, A., Sartorelli, A. C. 1990. Induction of the Differentiation of WEHI-3B D+ Monomyelocytic Leukemia Cells by Inhibitors of Topoisomerase II. Cancer Research, 50: 6723-6730. |
| ACLARUBICIN |
1 uM |
Jensen, P.B., et al.1990.Antagonistic Effect of Aclarubicin on the Cytotoxicity of Etoposide and 4'-(9-acridinylamino)-methanesulfon-m-anisidide in Human Small Cell Lung Cancer Cell Lines and on Topoisomerase II-Mediated DNA Clev. Cancer Res,50:3311-3316. |
| ACTINOMYCIN-D |
not available |
Rose, K. M. 1988. DNA Topoisomerases as Targets for Chemotherapy. Faseb J, 2: 2474-2478. |
| ADOCIAQUINONE-A |
IC90=118 uM |
Concepcion, G. P., Foderaro, T. A., Eldredge, G. S., Lobkovsky, E., Clardy, J., Barrows, L. R., Ireland, C. M. 1995. Topoisomerase II-Mediated DNA Cleavage by Adocia- and Xestoquinones From the Philippine Sponge Xestospongia sp. J Med Chem, 38: 4503-4507. |
| ADOCIAQUINONE-B |
not available |
Concepcion, G. P., Foderaro, T. A., Eldredge, G. S., Lobkovsky, E., Clardy, J., Barrows, L. R., Ireland, C. M. 1995. Topoisomerase II-Mediated DNA Cleavage by Adocia- and Xestoquinones From the Philippine Sponge Xestospongia sp. J Med Chem, 38: 4503-4507. |
| ADRIAMYCIN |
not available |
Rose, K. M. 1988. DNA Topoisomerases as Targets for Chemotherapy. Faseb J, 2: 2474-2478. |
| ALOE-EMODIN |
1 mM |
Muller, S. O., Eckert, I., Lutz, W. K., Stopper, H. 1996. Genotoxicity of the Laxative Drug Components Emodin, Aloe-emodin and Danthron in Mammalian Cells: Topoisomerase II Mediated? Mutat Res, 371: 165-173. |
| ALOE-EMODIN |
IC50=741 uM/ml |
Mueller, S. O., Stopper, H. 1999. Characterization of the Genotoxicity of Anthraquinones in Mammalian Cells. Biochimica & Biophysica Acta, 1428: 406-414. |
| ALPHA-BOSWELLIC-ACID-ACETATE |
IC>25=5 uM |
Duke, 1992 * |
| ALPHA-PELTATIN |
not available |
Thurston, L. S., Lee, K. H., Han, F. S., Liu, Z. C., Cheng, Y. C. Inhibition of Human DNA Topoisomerase II by Podophyllatoxin Analogues. Abstract Internat Res Cong Nat Prod Coll Pharm University N Carolina, Chapel Hill NC, July 1985. |
| APIGENIN |
IC28=18 uM |
Duke, 1992 * |
| APIGENIN |
IC45=180 uM |
Duke, 1992 * |
| APIGENIN |
50 ug/ml |
Azuma, Y., Onishi, Y., Sato, Y., Kizaki, H. 1995. Effects of Protein Tyrosine Kinase Inhibitors With Different Modes of Action on Topoisomerase Activity and Death of IL-2-Dependent CTLL-2-Cells. J Biochemistry, 118: 312-318. |
| APIODIONEN |
250 ug/ml |
Takahashi, H., Shiraishi, A., Iizuka, Y., Furuya, K., Kagasaki, T. 1992. Manufacture of Anticancer and Anti-Inflammatory Apiodionen With Apiosordaria. Patent, Japan Kokai Tokkyo Koho-04 49,289. 8pp. |
| ASCIDIDEMIN |
30 uM |
Schmitz, F. J., et al. 1991. Cytotoxic Aromatic Alkaloids From the Ascidian Amphicarpa meridiana and Leptoclinides sp.: Meridine and 11-hydroxyascididemin. J Org Chem, 56: 804-808. |
| BAICALEIN |
200 ug/ml |
Matsuzaki, Y., Kurokawa, N., Terai, S., Matsumura, Y., Kobayashi, N., Okita, K. 1996. Cell Death Induced by Baicalein in Human Hepatocellular Carcinoma Cell Lines. Jap J Cancer Res, 87: 170-177. |
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