Chemical GOSSYPOL | Dr. Duke's Phytochemical and Ethnobotanical Databases

Chemical ID

GOSSYPOL

Ubiquitous

List of known dosages
Dosage	Reference
LD50=2,315-2,570 (orl rat)	Cooper-Driver, G. A., Chemical substances in plants toxic to animals, pp. 213-47 in Rechcigl, M., Jr., ed. CRC Handbook of Naturally Occurring Food Toxicants, CRC Press, Boca Raton, 1983, 339 pp.
LD50=550 (orl pig)

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List of chemical activities.
Click on column headings to sort table by that column. *Unless otherwise noted all references are to (Duke, 1992)
Activity	Dosage	Reference
ACE-Inhibitor	hmn male	Duke, 1992 *
Aldose-Reductase-Inhibitor	not available	Deck, L. M., Vander Jagt, D. L., Royer, R. E. 1991. Gossypol and Derivatives: A New Class of Aldose Reductase Inhibitors. J Med Chem, 34(1): 3301-3305.
Amebicide	not available	Duke, 1992 *
Anaphrodisiac	not available	Martindale's 29th
Antibacterial	not available	Williamson, E. M. and Evans, F. J., Potter's New Cyclopaedia of Botanical Drugs and Preparations, Revised Ed., Saffron Walden, the C. W. Daniel Co., Ltd., Essex UK, 362 pp, 1988, reprint 1989.
Antibiotic	not available	Duke, 1992 *
Anticancer	not available	Duke, 1992 *
AntiCorpus-Luteum	not available	Duke, 1992 *
Antiencephalitic	not available	Duke, 1992 *
Antiestrogenic	not available	Economic & Medicinal Plant Research, 6: 189.
Antifeedant	not available	Jacobson, M., Glossary of Plant-Derived Insect Deterrents, CRC Press, Inc., Boca Raton, FL, 213 p, 1990.
Antifertility	30 mg/kg	Jacobson, M., Glossary of Plant-Derived Insect Deterrents, CRC Press, Inc., Boca Raton, FL, 213 p, 1990.
Antifertility	30 mg/kg rats	Duke, 1992 *
Antiflu	not available	Vlietinck, A.J. and Dommisse, R.A. eds. 1985. Advances in Medicinal Plant Research. Wiss. Verlag. Stuttgart.
Antiherpetic	not available	Duke, 1992 *
AntiHIV	not available	Duke, 1992 *
AntiHIV	100 uM	Duke, 1992 *
Antiimplantation	not available	Duke, 1992 *
Antikeratitic	not available	Duke, 1992 *
Antimalarial	IC50=10 uM	Duke, 1992 *

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List of chemical plants.
Click on column headings to sort table by that column. *Unless otherwise noted all references are to (Duke, 1992)
Plant Name	Plant Part	Low Parts Per Million	High Parts Per Million	Standard Deviation	Reference
Abelmoschus esculentus	Seed	32.0	70.0	-0.5	Duke, 1992 *
Ceiba pentandra	Seed	not available	not available	not available	Duke, 1992 *
Glycine max	Seed	not available	60.0	-0.5	Duke, 1992 *
Gossypium sp	Oil	500.0	7000.0	not available	Duke, 1992 *
Gossypium sp	Seed	50.0	2500.0	-0.3	Duke, 1992 *
Helianthus annuus	Seed	not available	10.0	-0.6	Duke, 1992 *
Thespesia populnea	Flower	not available	4000.0	not available	List, P.H. and Horhammer, L., Hager's Handbuch der Pharmazeutischen Praxis, Vols. 2-6, Springer-Verlag, Berlin, 1969-1979.
Thespesia populnea	Leaf	not available	16600.0	not available	ANON. 1948-1976. The Wealth of India raw materials. Publications and Information Directorate, CSIR, New Delhi. 11 volumes.
Thespesia populnea	Root	not available	12500.0	not available	List, P.H. and Horhammer, L., Hager's Handbuch der Pharmazeutischen Praxis, Vols. 2-6, Springer-Verlag, Berlin, 1969-1979.
Thespesia populnea	Seed	not available	31400.0	2.0	ANON. 1948-1976. The Wealth of India raw materials. Publications and Information Directorate, CSIR, New Delhi. 11 volumes.
Thespesia populnea	Stem	not available	14300.0	not available	ANON. 1948-1976. The Wealth of India raw materials. Publications and Information Directorate, CSIR, New Delhi. 11 volumes.