Chemical MAKALUVAMINE-E

List of chemical activities.
Click on column headings to sort table by that column. *Unless otherwise noted all references are to (Duke, 1992)

Activity Sort descending	Dosage	Reference
Topoisomerase-II-Inhibitor	MIC=133 ug/ml	Barrows, L. R., Radisky, D. C., Copp, B. R., Swaffar, D. S., Kramer, R. A., Warters, R. L., Ireland, C. M. 1993. Makaluvamines, Marine Natural Products are Active Anti-Cancer Agents and DNA Topo II Inhibitors. Anticancer Drug Design, 8: 333-347.
Topoisomerase-II-Inhibitor	IC50=310 uM	Radisky, D. C., Radisky, E. S., Barrows, L. R., Copp, B. R., Kramer, R. A., Ireland, C. M. 1993. Novel Cytotoxic Topoisomerase II Inhibiting Pyrroloiminoquinones From Fijian Sponges of the Genus Zyzzya. J Amer Chem Soc, 115: 1632-1638.