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Dr. Duke's Phytochemical and Ethnobotanical Databases
U.S. Department of Agriculture
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Topoisomerase-II-Inhibitor

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List of activity chemicals.
Click on column headings to sort table by that column. *Unless otherwise noted all references are to (Duke, 1992)
Chemical Name Dosage Reference
BAKUCHICIN IC50=404 uM Sun, N. J., Woo, S. H., Cassady, J. M., Snapka, R. M. 1998. DNA Polymerase and Topoisomerase II Inhibitors From Psoralea corylifolia. J Natural Products, 61: 362-366.
BASTADIN-14 IC50=2 ug/ml Carney, J. R., Scheuer, P. J., Borge, M. K. 1993. A New Bastadin From the Sponge Psammaplysilla purpurea. J Natural Products, 56: 153-157.
BERBERASTINE 2.5 uM Kobayashi, Y, Yamashita, Y., Fujii, N., Takaboshi, K., Kawakami, T., Kawamura, M., Mizukami, T., Nakano, H. 1995. Inhibitors of DNA Topoisomerase I and II Isolated From the Coptis Rhizomes. Planta Medica, 61: 414-418.
BERBERINE 2.5 uM Kobayashi, Y, Yamashita, Y., Fujii, N., Takaboshi, K., Kawakami, T., Kawamura, M., Mizukami, T., Nakano, H. 1995. Inhibitors of DNA Topoisomerase I and II Isolated From the Coptis Rhizomes. Planta Medica, 61: 414-418.
BERBERRUBINE 2.5 uM Kobayashi, Y, Yamashita, Y., Fujii, N., Takaboshi, K., Kawakami, T., Kawamura, M., Mizukami, T., Nakano, H. 1995. Inhibitors of DNA Topoisomerase I and II Isolated From the Coptis Rhizomes. Planta Medica, 61: 414-418.
BETA-BOSWELLIC-ACID-ACETATE Lee, Y. W., Fang, Q. C., Wang, Z. G., Li, D., Cook, C. E. 1990. Pentacyclic Triterpenoid Compounds as Topoisomerase Inhibitors or Cell Differentiation Inducers. Patent-Pct Int Appl-90 01,937. 54pp.
BETULIN IC50=38.6 uM *
BIOCHANIN-A 50 ug/ml Azuma, Y., Onishi, Y., Sato, Y., Kizaki, H. 1995. Effects of Protein Tyrosine Kinase Inhibitors With Different Modes of Action on Topoisomerase Activity and Death of IL-2-Dependent CTLL-2-Cells. J Biochemistry, 118: 312-318.
BIS-DEMETHOXYCURCUMIN 25 ug/ml *
BUFALIN 10 nM Jing, Y. K., Watabe, M., Hashimoto, S., Nakajo, S., Nakaya, K. 1994. Cell Cycle Arrest and Protein Kinase Modulating Effect of Bufalin on Human Leukemia ML1 Cells. Anticancer Research, 14: 1193-1198.
CAFFEINE 99 mM Shin, C. G., Strayer, J. M., Wani, M., Snapka, R. M. 1990. Rapid Evaluation of Topoisomerase Inhibitors: Caffeine Inhibition of Topoisomerases in vivo. Teratogen Carcinogen Mutagen, 10: 41-52.
CAMPTOTHECIN Rose, K. M. 1988. DNA Topoisomerases as Targets for Chemotherapy. Faseb J, 2: 2474-2478.
CASTALAGIN IC100=0.2 uM Kashiwada, Y., Nonaka, G. I., Nishioka, I., Lee, J. H., Bori, I., Fukushima, Y., Bastow, K. F., Lee, K. H. 1993. Tannins as Potent Inhibitors of DNA Topoisomerase II in vitro. J Pharm Sci, 82: 487-492.
CASTANOPSININ-A IC100=5-12.5 uM Kashiwada, Y., Nonaka, G. I., Nishioka, I., Lee, J. H., Bori, I., Fukushima, Y., Bastow, K. F., Lee, K. H. 1993. Tannins as Potent Inhibitors of DNA Topoisomerase II in vitro. J Pharm Sci, 82: 487-492.
CASUARININ IC100=0.2 uM Kashiwada, Y., Nonaka, G. I., Nishioka, I., Lee, J. H., Bori, I., Fukushima, Y., Bastow, K. F., Lee, K. H. 1993. Tannins as Potent Inhibitors of DNA Topoisomerase II in vitro. J Pharm Sci, 82: 487-492.
CHARTREUSIN 1 ug/l Lorico, A., Long, B. H. 1993. Biochemical Characterisation of Elsamicin and Other Coumarin-Related Antitumor Agents as Potent Inhibitors of Human Topoisomerase II. Eur J Cancer, 29: 1985-1991.
CHEBULAGIC-ACID IC100=0.5 uM Kashiwada, Y., Nonaka, G. I., Nishioka, I., Lee, J. H., Bori, I., Fukushima, Y., Bastow, K. F., Lee, K. H. 1993. Tannins as Potent Inhibitors of DNA Topoisomerase II in vitro. J Pharm Sci, 82: 487-492.
CHEBULINIC-ACID IC100=0.2 uM Kashiwada, Y., Nonaka, G. I., Nishioka, I., Lee, J. H., Bori, I., Fukushima, Y., Bastow, K. F., Lee, K. H. 1993. Tannins as Potent Inhibitors of DNA Topoisomerase II in vitro. J Pharm Sci, 82: 487-492.
CHRYSAZIN 1 mM Muller, S. O., Eckert, I., Lutz, W. K., Stopper, H. 1996. Genotoxicity of the Laxative Drug Components Emodin, Aloe-emodin and Danthron in Mammalian Cells: Topoisomerase II Mediated? Mutat Res, 371: 165-173.
CHRYSAZIN IC50=61 uM/ml Mueller, S. O., Stopper, H. 1999. Characterization of the Genotoxicity of Anthraquinones in Mammalian Cells. Biochimica & Biophysica Acta, 1428: 406-414.
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List of Activity Plants.
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Plant Name Common Name Chemical Count Total Parts Per Million
Triticum aestivum Wheat 2 0
Tropaeolum majus Nasturtium 1 0
Tsuga canadensis Eastern Hemlock 2 0
Turnera diffusa Damiana 1 0
Tussilago farfara Coltsfoot 2 3, 600
Ulex micranthus 1 0
Ulex sp 1 0
Uncaria catechu Gambir; Pale Catechu 1 0
Uncaria guianensis Cat's Claw; Una de Gato; Garabato Colorado; Tambor Huasca; Ungunagi 2 0
Uncaria tomentosa Cat's Claw; Garabato Amarillo; Una de Gato 1 0
Urginea maritima European Squill 1 0
Urtica dioica European Nettle; Stinging Nettle 4 26, 800
Vaccinium corymbosum Blueberry 5 0
Vaccinium macrocarpon Cranberry; Large Cranberry; American Cranberry 3 1, 500
Vaccinium myrtillus Bilberry; Whortleberry; Dwarf Bilberry 3 0
Vaccinium vitis-idaea Cowberry; Lingen; Lingonberry 3 0
Valeriana officinalis Valerian; Common Valerian; Garden-Heliotrope 2 0
Vandasina retusa 1 28
Vatica affinis 1 470
Viburnum cassinoides 1 0