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Dr. Duke's Phytochemical and Ethnobotanical Databases
U.S. Department of Agriculture
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Topoisomerase-I-Inhibitor

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List of activity chemicals.
Click on column headings to sort table by that column. *Unless otherwise noted all references are to (Duke, 1992)
Chemical Name Dosage Reference
DOTRIACOLIDE 2.6 ug/ml Ogawara, H., Horikawa, S., Yanagida, T., Nakno, M. M., Andoh, T., Ishii, K., Hori, M., Goto, T. A., Hamada, M., Umezawa, H. 1982. A Novel Deoxyribonuclease Inhibitor From Micromonospora. J Antibiot, 35: 248-250.
EPIBERBERINE 250 uM Kobayashi, Y, Yamashita, Y., Fujii, N., Takaboshi, K., Kawakami, T., Kawamura, M., Mizukami, T., Nakano, H. 1995. Inhibitors of DNA Topoisomerase I and II Isolated From the Coptis Rhizomes. Planta Medica, 61: 414-418.
EPIMANOALIDE-25-ACETAL IC50=25 uM Kobayashi,M., Okamoto,T., Hayashi,K., Yokayama,N., Sasaki,T., Kitagawa,I. 1994. Marine Natural Products. XXXII. Absolute Configurations of C-4 of the Manoalide Family, Biologically Active Sesterterpenes From the Marine Sponge. Chem Pharm Bull, 42: 265-270
EQUOL IC50=50 ppm Chang, Y. C., Nair, M. G., Nitiss, L. J. L. 1995. MEtabolites of Daidzein and Genistein and Their Biological Activities. J Natural Products, 58: 1901-1905.
FAGARONINE 0.15-100 uM *
FISETIN IC50=20.6 ug/ml *
FORMONETIN Santti, R., Makela, S., Strauss, L., Korman, J., Kostian, M. L. 1998. Phytoestrogens: Potential Endocrine Disruptors in Males. Toxicol Ind Health, 14: 223-237.
FORMONONETIN Santti, R., Makela, S., Strauss, L., Korman, J., Kostian, M. L. 1998. Phytoestrogens: Potential Endocrine Disruptors in Males. Toxicol Ind Health, 14: 223-237.
FREDERICAMYCIN-A 4.4 uM Latham, M. D., King, C. K., Gorycki, P., MacDonald, T. L., Ross, W. E. 1989. Inhibition of Topoisomerases by Fredericamycin A. Cancer Chemother Pharmacol, 24: 167-171.
GALANGIN Santti, R., Makela, S., Strauss, L., Korman, J., Kostian, M. L. 1998. Phytoestrogens: Potential Endocrine Disruptors in Males. Toxicol Ind Health, 14: 223-237.
GALLIC-ACID Hamada, S. I., Kataoka, T., Woo, J. T., Yamada, A., Yoshida, T., Nishimura, T., Otake, N., Nagai, K. 1997. Immunosuppressive Effects by Gallic Acid and Chebulagic Acid on CTL-Mediated Cytotoxicity. Biol Pharm Bull, 20: 1017-1019.
GENISTEIN IC50=250 ppm *
GENISTEIN 1-10 ug/ml Okura, A., Arakawa, H., Oka, H., Yoshinari, T., Monden, Y. 1988. Effect of Genistein on Topoisomerase Activity and on the Growth of [VAL 12]HA-RAS-Transformed NIH 3T3 Cells. Biochem Biophys Res Commun, 157: 183-189.
GROENLANDICINE 250 uM Kobayashi, Y, Yamashita, Y., Fujii, N., Takaboshi, K., Kawakami, T., Kawamura, M., Mizukami, T., Nakano, H. 1995. Inhibitors of DNA Topoisomerase I and II Isolated From the Coptis Rhizomes. Planta Medica, 61: 414-418.
HALENAQUINONE 0.3 ug/ml Bae, M. A., Tsuji, T., Kondo, K., Hirase, T., Ishibashi, M., Shigemori, H., Kobayashi, J. I. 1993. Inhibition of Mammalian Topoisomerase I by Xestoquinone and Halenaquinone. Biosci. Biotech. Biochem., 57: 330-331.
HARMAN ED50=23.8 ug/ml (weak) Funayama, Y., Nishio, K., Kabayashi, K., Nagao, M., Shimoi, K., Ohira, T., Hasegawa, S., Saijo, N. 1996. Effects of Beta- and Gamma-carboline Derivatives on DNA Topoisomerase Activities. Mutat Research, 249: 183-191.
ISORABDOSIIN 50 uM Kashiwada, Y., Bastow, K. F., Lee, K. H. 1995. Novel Lignan Derivatives as Selective Inhibitors of DNA Topoisomerase II. Bioorg Med Chem Lett, 5: 905-908.
KAEMPFERIDE Santti, R., Makela, S., Strauss, L., Korman, J., Kostian, M. L. 1998. Phytoestrogens: Potential Endocrine Disruptors in Males. Toxicol Ind Health, 14: 223-237.
KAEMPFEROL Santti, R., Makela, S., Strauss, L., Korman, J., Kostian, M. L. 1998. Phytoestrogens: Potential Endocrine Disruptors in Males. Toxicol Ind Health, 14: 223-237.
LUTEOLIN Santti, R., Makela, S., Strauss, L., Korman, J., Kostian, M. L. 1998. Phytoestrogens: Potential Endocrine Disruptors in Males. Toxicol Ind Health, 14: 223-237.
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List of Activity Plants.
Click on column headings to sort table by that column.
Plant Name Common Name Chemical Count Total Parts Per Million
Tridax procumbens Coatbuttons; Mexican daisy 2 0
Trifolium alexandrinum 1 0
Trifolium brachycalycinum 1 25, 800
Trifolium hybridum 1 0
Trifolium pratense Red Clover; Purple Clover; Peavine Clover; Cowgrass 7 93, 176
Trifolium repens 1 0
Trifolium sp 1 0
Trifolium subterraneum 1 27, 000
Trigonella foenum-graecum Fenugreek; Greek Clover; Greek Hay; Bockshornklee (Ger.); Alholva (Sp.) 6 100
Triticum aestivum Wheat 2 0
Tsuga canadensis Eastern Hemlock 1 0
Turnera diffusa Damiana 1 0
Tussilago farfara Coltsfoot 2 0
Ulex micranthus 1 0
Ulex sp 1 0
Uncaria catechu Gambir; Pale Catechu 2 0
Uncaria guianensis Cat's Claw; Una de Gato; Garabato Colorado; Tambor Huasca; Ungunagi 1 0
Urginea maritima European Squill 2 0
Urtica dioica European Nettle; Stinging Nettle 3 0
Vaccinium corymbosum Blueberry 3 0