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Dr. Duke's Phytochemical and Ethnobotanical Databases
U.S. Department of Agriculture
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Antimalarial

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List of activity chemicals.
Click on column headings to sort table by that column. *Unless otherwise noted all references are to (Duke, 1992)
Chemical Name Dosage Reference
3-METHYLNAPHTHARAZIN IC50=5.8 uM Rukunga, G. and Simons, A. J. 2006. The Potential of Plants as a Source of Antimalarial Agents - A Review. Africa Herbal Antimalaria Meeting. PlantaPhile Publications, Berlin. 72 pp.
3-O-BENZOYLHOSLOPPONE IC50=0.4 ug/ml Rukunga, G. and Simons, A. J. 2006. The Potential of Plants as a Source of Antimalarial Agents - A Review. Africa Herbal Antimalaria Meeting. PlantaPhile Publications, Berlin. 72 pp.
4,7-DIMETHYL-1-TETRALONE EC50=>3-100 uM *
5,6,7-TRIMETHOXYCOUMARIN IC50=1ug/ml *
5,7-DIMETHOXY-8-(3'-HYDROXY-3'-METHYL-1'-BUTENE) IC50=8.8-16.25 ug/ml Rukunga, G. and Simons, A. J. 2006. The Potential of Plants as a Source of Antimalarial Agents - A Review. Africa Herbal Antimalaria Meeting. PlantaPhile Publications, Berlin. 72 pp.
6'-DESMETHYL-THALIFABORAMINE IC50=0.01-0.15 ug/ml Rukunga, G. and Simons, A. J. 2006. The Potential of Plants as a Source of Antimalarial Agents - A Review. Africa Herbal Antimalaria Meeting. PlantaPhile Publications, Berlin. 72 pp.
6-ACETYLSWIETENOLIDE IC50=7.5 ug/ml Rukunga, G. and Simons, A. J. 2006. The Potential of Plants as a Source of Antimalarial Agents - A Review. Africa Herbal Antimalaria Meeting. PlantaPhile Publications, Berlin. 72 pp.
6-ALPHA-TIGLOYLOXYGLAUCARUBOL IC50=0.257 ug/ml Rukunga, G. and Simons, A. J. 2006. The Potential of Plants as a Source of Antimalarial Agents - A Review. Africa Herbal Antimalaria Meeting. PlantaPhile Publications, Berlin. 72 pp.
7-DEACETYLGEDUNIN IC50=3.6 ug/ml Zeits. Lebensmitt. Unters. & Forsch. Acta Botanica Sinica, 174(3):211. 1982.
7-DEACETYLKHIVORIN IC50=5 ug/ml *
7-EPIDIONCHOPHYLLINE-A IC50=0.2 ug/ml Rukunga, G. and Simons, A. J. 2006. The Potential of Plants as a Source of Antimalarial Agents - A Review. Africa Herbal Antimalaria Meeting. PlantaPhile Publications, Berlin. 72 pp.
7-METHOXY-BETA-CARBOLINE-1-PROPIONIC-ACID IC50=0.3-2.9 ug/ml Rukunga, G. and Simons, A. J. 2006. The Potential of Plants as a Source of Antimalarial Agents - A Review. Africa Herbal Antimalaria Meeting. PlantaPhile Publications, Berlin. 72 pp.
7-O-DEMETHYLTETRANDRINE IC50=0.74 ug/ml Rukunga, G. and Simons, A. J. 2006. The Potential of Plants as a Source of Antimalarial Agents - A Review. Africa Herbal Antimalaria Meeting. PlantaPhile Publications, Berlin. 72 pp.
8-EPIXANTHIN IC50=125 ug/ml Rukunga, G. and Simons, A. J. 2006. The Potential of Plants as a Source of Antimalarial Agents - A Review. Africa Herbal Antimalaria Meeting. PlantaPhile Publications, Berlin. 72 pp.
8-EPIXANTHIN-1,5-EPOXIDE IC50=7.8 ug/ml Rukunga, G. and Simons, A. J. 2006. The Potential of Plants as a Source of Antimalarial Agents - A Review. Africa Herbal Antimalaria Meeting. PlantaPhile Publications, Berlin. 72 pp.
ACACETIN IC50=4.2-12.6 ug/ml *
AFFINISINE IC50=5->5 ug/ml Rukunga, G. and Simons, A. J. 2006. The Potential of Plants as a Source of Antimalarial Agents - A Review. Africa Herbal Antimalaria Meeting. PlantaPhile Publications, Berlin. 72 pp.
AILANTHINONE IC50=0.025 uM *
AILANTHONE Williamson, E. M. and Evans, F. J., Potter's New Cyclopaedia of Botanical Drugs and Preparations, Revised Ed., Saffron Walden, the C. W. Daniel Co., Ltd., Essex UK, 362 pp, 1988, reprint 1989.
AJOENE 50 mg/kg *
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List of Activity Plants.
Click on column headings to sort table by that column.
Plant Name Common Name Chemical Count Total Parts Per Million
Spinacia oleracea Spinach 2 189
Spondianthus preussii 1 12, 000
Stellaria media Chickweed; Common Chickweed 1 0
Stemonoporus affinis 1 0
Stemonoporus canaliculatus 1 0
Stemonoporus cordifolius 1 0
Stemonoporus oblongifolius 1 0
Stemonoporus petiolaris 1 0
Stemonoporus reticulatus 1 0
Stephania glabra Indian Tape-Vine 4 0
Stephania japonica Japanese Tape-Vine 2 0
Stephania tetrandra Stephania 1 0
Stevia rebaudiana Ca-A-E; Sweet Leaf of Paraguay; Stevia 5 237
Strychnos nux-vomica Nux-Vomica; Stychnine 3 1, 940
Sweetia panamensis Billy Webb; Cascara Amarga 1 0
Swertia chirata Chirata; Chiretta 2 0
Symplocos racemosa 1 0
Syncarpia glomulifera 1 12, 000
Syncarpia laurifolia 1 12, 000
Syringa vulgaris Lilac 2 0